The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance

Journal of Hypertension

Volumn 27, Issue SUPPL. 6, 2009, Pages

  De Las Heras, Natalia ^b   Martín Fernández, Beatriz ^b   Miana, Maria ^b   Ballesteros, Sandra ^b   Oubiña, Maria Pilar ^b   López Farré, Antonio J ^a   Cachofeiro, Victoria ^b   Lahera, Vicente ^b  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Adiponectin; Adipose tissue; Angiotensin II blockade; High fat diet; Leptin; Obesity

Indexed keywords

ADIPONECTIN; ANGIOTENSIN I; ANGIOTENSIN II; INSULIN; IRBESARTAN; LEPTIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; BODY WEIGHT; BROWN ADIPOSE TISSUE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFICACY; EPIDIDYMIS FAT; GLUCOSE METABOLISM; HEART FUNCTION; HEART PROTECTION; INSULIN SENSITIVITY; LIPID DIET; LUMBAR SPINE; MALE; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RAT; VASCULAR RING; WHITE ADIPOSE TISSUE;

EID: 70349297078     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.hjh.0000358836.64052.43     Document Type: Article

References (19)

1. Guerre-Millo M. Adipose tissue and adipokines: for better or worse. Diabetes Metab 2004; 30:13-19.
2. Hattori Y, Akimoto K, Gross SS, Hattori S, Kasai K. Angiotensin-ll- induced oxidative stress elicits hypoadiponectinaemia in rats. Diabetologia 2005; 48:1066-1074. (Pubitemid 40909640)
3. Rueda-Clausen CF, Lahera V, Calderon J, Bolivar IC, Castillo VR, Gutierrez M, et al. The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors, Int J Cardiol 2008 Oct 13 [Epub ahead of print].
4. Shirer HW. Blood pressure measuring methods. Ire Trans Biomed Electron 1962; BME-9:116-125.
5. Zhao X, Wu N, Deng M, Yin Y, Zhou J, Fang Y, Huang L An improved method of left ventricular catheterization in rats. Physiol Meas 2006; 27:N27-N33.
6. Maeso R, Navarro-Cid J, Munoz-Garcia R, Rodrigo E, Ruilope L, Lahera V, Cachofeiro V. Losartan reduces phenylephrine constrictor response in aortic rings from spontaneously hypertensive rats. Role of nitric oxide and angiotensin Il type 2 receptors. Hypertension 1996; 28:967-972. (Pubitemid 26415812)
7. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23:57-63. (Pubitemid 30022895)
8. de las Heras N, Ruiz-Ortega M, Miana M, Ruperez M, Sanz-Rosa D, Aragoncillo P, et al. Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats. J Hypertens 2007; 25:629-638.
9. Massiera F, Seydoux J, Geloen A, Quignard-Boulange A, Turban S, SaintMarc P, et al. Angiotensinogen-deficient mice exhibit impairment of dietinduced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology 2001; 142:5220-5225. (Pubitemid 33131951)
10. Saint-Marc P, Kozak LP, Ailhaud G, Darimont C, Negrel R. Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation. Endocrinology 2001; 142:487-492. (Pubitemid 32183711)
11. Furuhashi M, Ura N, Takizawa H, Yoshida D, Moniwa N, Murakami H, et al. Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity. J Hypertens 2004; 22:1977-1982. (Pubitemid 39336681)
12. Fasshauer M, Paschke R, Stumvoll M. Adiponectin, obesity, and cardiovascular disease. Biochimie 2004; 86:779-784.
13. Aguilera CM, Gil-Campos M, Canete R, Gil A. Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome. Clin Sci (Lond) 2008; 114:183-193. (Pubitemid 351293994)
14. Gustafson B, Jack MM, Cushman SW, Smith U. Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes. Biochem Biophys Res Commun 2003; 308:933-939. (Pubitemid 36976549)
15. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, et al. Functional antagonism between CCAAT/enhancer binding proteinalpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem 1997; 272:5283-5290. (Pubitemid 27090091)
16. Peraldi P, Spiegelman B. TNF-alpha and insulin resistance: summary and future prospects. Mol Cell Biochem 1998; 182:169-175. (Pubitemid 28181660)
17. Xing H, Northrop JP, Grove JR, Kilpatrick KE, Su JL, Ringold GM. TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression. Endocrinology 1997; 138:2776-2783. (Pubitemid 27258506)
18. Arenas IA, Xu Y, Lopez-Jaramillo P, Davidge ST. Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha. Am J Physiol Cell Physiol 2004; 286:C779-C784.
19. Lopez-Jaramillo P. Defining the research priorities to fight the burden of cardiovascular diseases in Latin America. J Hypertens 2008; 26:1886-1889.