메뉴 건너뛰기




Volumn 49, Issue 2, 2012, Pages 111-122

The effects of adiponectin and leptin on human endothelial cell proliferation: A live-cell study

Author keywords

Adiponectin; Endothelial cells; Leptin; Live cell image technique; Proliferation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ADIPONECTIN; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 84863394792     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000332332     Document Type: Article
Times cited : (12)

References (47)
  • 2
    • 33644850953 scopus 로고    scopus 로고
    • American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: A 1997 update
    • Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH: American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: a 1997 update. Circulation 2006; 113: 898-918.
    • (2006) Circulation , vol.113 , pp. 898-918
    • Poirier, P.1    Giles, T.D.2    Bray, G.A.3    Hong, Y.4    Stern, J.S.5    Pi-Sunyer, F.X.6    Eckel, R.H.7
  • 4
    • 2942657650 scopus 로고    scopus 로고
    • Medical consequences of obesity
    • Bray GA: Medical consequences of obesity. J Clin Endocrinol Metab 2004; 89: 2583-2589.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2583-2589
    • Bray, G.A.1
  • 5
    • 34547808142 scopus 로고    scopus 로고
    • Local adipose tissue depots as cardiovascular risk factors
    • DOI 10.1016/j.cardiores.2007.03.008, PII S0008636307001137
    • Thalmann S, Méier CA: Local adipose tissue depots as cardiovascular risk factors. Cardiovasc Res 2007; 75: 690-701. (Pubitemid 47238732)
    • (2007) Cardiovascular Research , vol.75 , Issue.4 , pp. 690-701
    • Thalmann, S.1    Meier, C.A.2
  • 6
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG: Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000; 87: 840-844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 7
    • 0035960677 scopus 로고    scopus 로고
    • Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    • Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T: Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001; 104: 2673-2678. (Pubitemid 33108132)
    • (2001) Circulation , vol.104 , Issue.22 , pp. 2673-2678
    • Heitzer, T.1    Schlinzig, T.2    Krohn, K.3    Meinertz, T.4    Munzel, T.5
  • 8
    • 68249147814 scopus 로고    scopus 로고
    • Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects
    • Rueda-Clausen CF, López-Jaramillo P, Luengas C, Oubiña MP, Cachofeiro V, Lahera V: Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects. Mediators Inflamm 2009; 2009: 469169.
    • (2009) Mediators Inflamm , vol.2009 , pp. 469169
    • Rueda-Clausen, C.F.1    López-Jaramillo, P.2    Luengas, C.3    Oubiña, M.P.4    Cachofeiro, V.5    Lahera, V.6
  • 11
    • 0036678916 scopus 로고    scopus 로고
    • Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women
    • Matsubara M, Maruoka S, Katayose S: Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002; 147: 173-180.
    • (2002) Eur J Endocrinol , vol.147 , pp. 173-180
    • Matsubara, M.1    Maruoka, S.2    Katayose, S.3
  • 12
    • 0042023742 scopus 로고    scopus 로고
    • Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity
    • DOI 10.2337/diacare.26.8.2383
    • Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, Egan JS, Elahi D: Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care 2003; 26: 2383-2388. (Pubitemid 36993330)
    • (2003) Diabetes Care , vol.26 , Issue.8 , pp. 2383-2388
    • Ryan, A.S.1    Berman, D.M.2    Nicklas, B.J.3    Sinha, M.4    Gingerich, R.L.5    Meneilly, G.S.6    Egan, J.M.7    Elahi, D.8
  • 14
    • 0037066603 scopus 로고    scopus 로고
    • ACRP30, a new hormone controlling fat and glucose metabolism
    • Tsao TS, Lodish HF, Fruebis J: ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol 2002; 440: 213- 221.
    • (2002) Eur J Pharmacol , vol.440 , pp. 213-221
    • Tsao, T.S.1    Lodish, H.F.2    Fruebis, J.3
  • 15
    • 33749580515 scopus 로고    scopus 로고
    • Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults
    • Im JA, Kim SH, Lee JW, Shim JY, Lee HR, Lee DC: Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults. Metabolism 2006; 55: 1546-1550.
    • (2006) Metabolism , vol.55 , pp. 1546-1550
    • Im, J.A.1    Kim, S.H.2    Lee, J.W.3    Shim, J.Y.4    Lee, H.R.5    Lee, D.C.6
  • 16
    • 34248147538 scopus 로고    scopus 로고
    • Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
    • DOI 10.2337/db06-1580
    • Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A: Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 2007; 56: 1387-1394. (Pubitemid 46715600)
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1387-1394
    • Cheng, K.K.Y.1    Lam, K.S.L.2    Wang, Y.3    Huang, Y.4    Carling, D.5    Wu, D.6    Wong, C.7    Xu, A.8
  • 17
    • 0842332231 scopus 로고    scopus 로고
    • Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
    • DOI 10.1016/j.bbrc.2004.01.049
    • Motoshima H, Wu X, Mahadev K, Golstein BJ: Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 2004; 315: 264-271. (Pubitemid 38183103)
    • (2004) Biochemical and Biophysical Research Communications , vol.315 , Issue.2 , pp. 264-271
    • Motoshima, H.1    Wu, X.2    Mahadev, K.3    Goldstein, B.J.4
  • 18
    • 58149462249 scopus 로고    scopus 로고
    • The expression of adiponectin receptors and the effects of adiponectin and leptin on airway smooth muscle cells
    • Shin JH, Kim JH, Lee WY, Shim JY: The expression of adiponectin receptors and the effects of adiponectin and leptin on airway smooth muscle cells. Yonsei Med J 2008; 49: 804-810.
    • (2008) Yonsei Med J , vol.49 , pp. 804-810
    • Shin, J.H.1    Kim, J.H.2    Lee, W.Y.3    Shim, J.Y.4
  • 19
    • 39549094717 scopus 로고    scopus 로고
    • Vascular effects of adiponectin: Molecular mechanisms and potential therapeutic intervention
    • DOI 10.1042/CS20070347
    • Zhu W, Cheng KK, Vanhoutte PM, Lam KS, Xu A: Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) 2008; 114: 361-374. (Pubitemid 351397385)
    • (2008) Clinical Science , vol.114 , Issue.5-6 , pp. 361-374
    • Zhu, W.1    Cheng, K.K.Y.2    Vanhoutte, P.M.3    Lam, K.S.L.4    Xu, A.5
  • 20
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • DOI 10.1210/er.2005-0005
    • Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev 2005; 26: 439-451. (Pubitemid 40686653)
    • (2005) Endocrine Reviews , vol.26 , Issue.3 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 21
    • 68949120737 scopus 로고    scopus 로고
    • Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond
    • Könner AC, Klöckener T, Brüning JC: Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond. Physiol Behav 2009; 97: 632-638.
    • (2009) Physiol Behav , vol.97 , pp. 632-638
    • Könner, A.C.1    Klöckener, T.2    Brüning, J.C.3
  • 22
    • 52949129178 scopus 로고    scopus 로고
    • Leptin resistance: A possible interface of inflammation and metabolism in obesity-related cardiovascular disease
    • Martin SS, Qasim A, Reilly MP: Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008; 52: 1201-1210.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1201-1210
    • Martin, S.S.1    Qasim, A.2    Reilly, M.P.3
  • 23
    • 33748970803 scopus 로고    scopus 로고
    • Leptin and atherosclerosis
    • Beltowski J: Leptin and atherosclerosis. Atherosclerosis 2006; 189: 47-60.
    • (2006) Atherosclerosis , vol.189 , pp. 47-60
    • Beltowski, J.1
  • 24
    • 34247325960 scopus 로고    scopus 로고
    • Adipose tissue and atherosclerosis: Exploring the connection
    • Fantuzzi G, Mazzone T: Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol 2007; 27: 996- 1003.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 996-1003
    • Fantuzzi, G.1    Mazzone, T.2
  • 25
    • 19444375353 scopus 로고    scopus 로고
    • Effects of adipocyte-derived cytokines on endothelial functions: Implication of vascular disease
    • DOI 10.1016/j.jss.2004.12.023, PII S002248040500003X
    • Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C: Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease. J Surg Res 2005; 126: 121-129. (Pubitemid 40726256)
    • (2005) Journal of Surgical Research , vol.126 , Issue.1 , pp. 121-129
    • Kougias, P.1    Chai, H.2    Lin, P.H.3    Yao, Q.4    Lumsden, A.B.5    Chen, C.6
  • 26
    • 52449095361 scopus 로고    scopus 로고
    • The RSK family of kinases: Emerging roles in cellular signalling
    • Anjum R and Blenis J: The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 2008; 9: 747-758.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 27
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
    • DOI 10.1074/jbc.M310389200
    • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K: Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004; 279: 1304-1309. (Pubitemid 38082655)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.2 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3    Kumada, M.4    Sato, K.5    Inoue, T.6    Funahashi, T.7    Walsh, K.8
  • 28
    • 78951469092 scopus 로고    scopus 로고
    • Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: Association with enhanced serum and glucocorticoid- regulated kinase-1 expression
    • Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Delgado C, Song S, Hintze T, Cachofeiro V, Lahera V: Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid- regulated kinase-1 expression. J Cardiovasc Pharmacol 2011; 57: 114-121.
    • (2011) J Cardiovasc Pharmacol , vol.57 , pp. 114-121
    • Martín-Fernández, B.1    De Las Heras, N.2    Miana, M.3    Ballesteros, S.4    Delgado, C.5    Song, S.6    Hintze, T.7    Cachofeiro, V.8    Lahera, V.9
  • 30
    • 26244432063 scopus 로고    scopus 로고
    • Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    • DOI 10.1016/j.atherosclerosis.2005.03.048, PII S0021915005001978
    • Wolk R, Deb A, Caplice NM, Somers VK: Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis 2005; 183: 131-139. (Pubitemid 41416831)
    • (2005) Atherosclerosis , vol.183 , Issue.1 , pp. 131-139
    • Wolk, R.1    Deb, A.2    Caplice, N.M.3    Somers, V.K.4
  • 31
    • 3142616447 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling
    • DOI 10.1074/jbc.M402558200
    • Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, Walsh K: Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. J Biol Chem 2004; 279: 28670-28674. (Pubitemid 38900150)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.27 , pp. 28670-28674
    • Shibata, R.1    Ouchi, N.2    Kihara, S.3    Sato, K.4    Funahashi, T.5    Walsh, K.6
  • 34
    • 45249085983 scopus 로고    scopus 로고
    • Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells: Globular adiponectin vs. high molecular weight adiponectin
    • DOI 10.3132/dvdr.2008.020, Circadian rhythms
    • Tomizawa A, Hattori Y, Kasai K, Nakano Y: Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells: globular adiponectin versus high molecular weight adiponectin. Diab Vasc Dis Res 2008; 5: 123-127. (Pubitemid 351839284)
    • (2008) Diabetes and Vascular Disease Research , vol.5 , Issue.2 , pp. 123-127
    • Tomizawa, A.1    Hattori, Y.2    Kasai, K.3    Nakano, Y.4
  • 37
    • 4444280556 scopus 로고    scopus 로고
    • Angiotensin II-induced apoptosis in human endothelial cells is inhibited by adiponectin through restoration of the association between endothelial nitric oxide synthase and heat shock protein 90
    • Lin LY, Lin CY, Su TC, Liau CS: Angiotensin II-induced apoptosis in human endothelial cells is inhibited by adiponectin through restoration of the association between endothelial nitric oxide synthase and heat shock protein 90. FEBS Lett 2004; 574: 106-110.
    • (2004) FEBS Lett , vol.574 , pp. 106-110
    • Lin, L.Y.1    Lin, C.Y.2    Su, T.C.3    Liau, C.S.4
  • 38
    • 42149117692 scopus 로고    scopus 로고
    • Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells
    • DOI 10.1093/cvr/cvn034
    • Mahadev K, Wu X, Donnelly S, Ouedraogo R, Eckhart AD, Goldstein BJ: Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc Res 2008; 78: 376-384. (Pubitemid 351556105)
    • (2008) Cardiovascular Research , vol.78 , Issue.2 , pp. 376-384
    • Mahadev, K.1    Wu, X.2    Donnelly, S.3    Ouedraogo, R.4    Eckhart, A.D.5    Goldstein, B.J.6
  • 40
    • 51149093513 scopus 로고    scopus 로고
    • Hemangiopoietin promotes endothelial cell proliferation through PI-3K/ Akt pathway
    • Chen Z, Liu F, Ren Q, Zhao Q, Ren H, Lu S, Zhang L, Han Z: Hemangiopoietin promotes endothelial cell proliferation through PI-3K/ Akt pathway. Cell Physiol Biochem 2008; 22: 307-314.
    • (2008) Cell Physiol Biochem , vol.22 , pp. 307-314
    • Chen, Z.1    Liu, F.2    Ren, Q.3    Zhao, Q.4    Ren, H.5    Lu, S.6    Zhang, L.7    Han, Z.8
  • 41
    • 22544449239 scopus 로고    scopus 로고
    • IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/ Akt pathway
    • Grehan JF, Levay-Young B.K, Fogelson J.L, François-Bogarçon V, Benson BA, Dalmasso AP: IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/ Akt pathway. J Immunol 2005; 175: 1903- 1910.
    • (2005) J Immunol , vol.175 , pp. 1903-1910
    • Grehan, J.F.1    Levay-Young, B.K.2    Fogelson, J.L.3    François- Bogarçon, V.4    Benson, B.A.5    Dalmasso, A.P.6
  • 42
    • 0642364978 scopus 로고    scopus 로고
    • RANKL regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/ Akt signal transduction pathway
    • Kim HH, Shin HS, Kwak HJ, Ahn KY, Kim JH, Lee HJ, Lee MS, Lee ZH, Koh GY: RANKL regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/ Akt signal transduction pathway. FASEB J 2003; 17: 2163-2165.
    • (2003) FASEB J , vol.17 , pp. 2163-2165
    • Kim, H.H.1    Shin, H.S.2    Kwak, H.J.3    Ahn, K.Y.4    Kim, J.H.5    Lee, H.J.6    Lee, M.S.7    Lee, Z.H.8    Koh, G.Y.9
  • 43
    • 55249090400 scopus 로고    scopus 로고
    • The adiponectin receptors adipoR1 and adipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth
    • Lee M, Klein RL, El-Shewy H.M, Luttrell DK, Luttrell LM: The adiponectin receptors adipoR1 and adipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry 2008; 47: 11682-11692.
    • (2008) Biochemistry , vol.47 , pp. 11682-11692
    • Lee, M.1    Klein, R.L.2    El-Shewy, H.M.3    Luttrell, D.K.4    Luttrell, L.M.5
  • 44
    • 69349090602 scopus 로고    scopus 로고
    • Induction of gene expression in response to globular adiponectin in vascular endothelial cells
    • Tomizawa A, Hattori Y and Kasai K: Induction of gene expression in response to globular adiponectin in vascular endothelial cells. Life Sci 2009; 85: 457-461.
    • (2009) Life Sci , vol.85 , pp. 457-461
    • Tomizawa, A.1    Hattori, Y.2    Kasai, K.3
  • 46
    • 26244432063 scopus 로고    scopus 로고
    • Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    • DOI 10.1016/j.atherosclerosis.2005.03.048, PII S0021915005001978
    • Wolk R, Deb A, Caplice NM, Somers VK: Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis 2005; 183: 131-139. (Pubitemid 41416831)
    • (2005) Atherosclerosis , vol.183 , Issue.1 , pp. 131-139
    • Wolk, R.1    Deb, A.2    Caplice, N.M.3    Somers, V.K.4
  • 47
    • 56649086772 scopus 로고    scopus 로고
    • Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity
    • Chen JX, Stinnett A: Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity. Lab Invest 2008; 88: 1316-1328.
    • (2008) Lab Invest , vol.88 , pp. 1316-1328
    • Chen, J.X.1    Stinnett, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.