Lycopene protects bone marrow mesenchymal stem cells against ischemia-induced apoptosis in vitro

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 11, 2014, Pages 1625-1631

  Li, Y ^a   Xue, F ^a   Xu, S Z ^b   Wang, X W ^b   Tong, X ^b   Lin, X J ^b  

^a Department of Orthopaedic Fengxian Center Hospital of the Sixth Hospital of Shanghai ^*  (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Bone marrow mesenchymal stem cells; Lycopene; PI3K Akt pathway; Reactive oxygen species

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; INDUCIBLE NITRIC OXIDE SYNTHASE; LYCOPENE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; CAROTENOID;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HEMATOPOIETIC STEM CELL; HYPOXIC CELL; IN VITRO STUDY; ISCHEMIA; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL HYPOXIA; CYTOLOGY; DRUG EFFECTS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BONE MARROW CELLS; CAROTENOIDS; CELL HYPOXIA; ISCHEMIA; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 84927170404     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Pereira Rf, Halford Kw, O'hara Md, Leeper Db, Sokolov Bp, Pollard Md, Bagasra O, Prockop Dj. Cultured Adherent Cells From Marrow Can Serve As Long-Lasting Precursor Cells For Bone, Cartilage, And Lung In Irradiated Mice. Proc Natl Acad Sci U S A 1995; 92: 4857-4861
2. Azizi Sa, Stokes D, Augelli Bj, Digirolamo C, Prockop Dj. Engraftment And Migration Of Human Bone Marrow Stromal Cells Implanted In The Brains Of Albino Rats-Similarities To Astrocyte Grafts. Proc Natl Acad Sci U S A 1998; 95: 3908-3913
3. Ferrari G, Cusella-De Ag, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F. Muscle Regeneration By Bone Marrow-Derived Myogenic Progenitors. Science 1998; 279: 1528-1530
4. Rosova I, Dao M, Capoccia B, Link D, Nolta Ja. Hypoxic Preconditioning Results In Increased Motility And Improved Therapeutic Potential Of Human Mesenchymal Stem Cells. Stem Cells 2008; 26: 2173-2182
5. Iwase T, Nagaya N, Fujii T, Itoh T, Murakami S, Matsumoto T, Kangawa K, Kitamura S. Comparison Of Angiogenic Potency Between Mesenchymal Stem Cells And Mononuclear Cells In A Rat Model Of Hindlimb Ischemia. Cardiovasc Res 2005; 66: 543-551
6. Yu Y, Yao Ah, Chen N, Pu Ly, Fan Y, Lv L, Sun Bc, Li Gq, Wang Xh. Mesenchymal Stem Cells Over-Expressing Hepatocyte Growth Factor Improve Smallfor-Size Liver Grafts Regeneration. Mol Ther 2007; 15: 1382-1389
7. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. Vegf Improves Survival Of Mesenchymal Stem Cells In Infarcted Hearts. Biochem Biophys Res Commun 2008; 376: 419-422
8. Toma C, Pittenger Mf, Cahill Ks, Byrne Bj, Kessler Pd. Human Mesenchymal Stem Cells Differentiate To A Cardiomyocyte Phenotype In The Adult Murine Heart. Circulation 2002; 105: 93-98
9. Zhu W, Chen J, Cong X, Hu S, Chen X. Hypoxia And Serum Deprivation-Induced Apoptosis In Mesenchymal Stem Cells. Stem Cells 2006; 24: 416-425
10. Matsui T, Li L, Del M, Fukui Y, Franke Tf, Hajjar Rj, Rosenzweig A. Adenoviral Gene Transfer Of Activated Phosphatidylinositol 3'-Kinase And Akt Inhibits Apoptosis Of Hypoxic Cardiomyocytes In Vitro. Circulation 1999; 100: 2373-2379
11. Chen J, Baydoun Ar, Xu R, Deng L, Liu X, Zhu W, Shi L, Cong X, Hu S, Chen X. Lysophosphatidic Acid Protects Mesenchymal Stem Cells Against Hypoxia And Serum Deprivation-Induced Apoptosis. Stem Cells 2008; 26: 135-145
12. Xu Z, Yan L, Ge Y, Zhang Q, Yang N, Zhang M, Zhao Y, Sun P, Gao J, Tao Z, Yang Z. Effect Of The Calcium Sensing Receptor On Rat Bone Marrow-Derived Mesenchymal Stem Cell Proliferation Through The Erk1/2 Pathway.Mol Biol Rep 2012; 39: 7271-7279
13. Tropel P, Noel D, Platet N, Legrand P, Benabid Al, Berger F. Isolation And Characterisation Of Mesenchymal Stem Cells From Adult Mouse Bone Marrow. Exp Cell Res 2004; 295: 395-406
14. Meng Zx, Nie J, Ling Jj, Sun Jx, Zhu Yx, Gao L, Lv Jh, Zhu Dy, Sun Yj, Han X. Activation Of Liver X Receptors Inhibits Pancreatic Islet Beta Cell Proliferation Through Cell Cycle Arrest. Diabetologia 2009; 52: 125-135
15. Ji Jf, He Bp, Dheen St, Tay Ss. Interactions Of Chemokines And Chemokine Receptors Mediate The Migration Of Mesenchymal Stem Cells To The Impaired Site In The Brain After Hypoglossal Nerve Injury. Stem Cells 2004; 22: 415-427
16. Da Sml, Chagastelles Pc, Nardi Nb. Mesenchymal Stem Cells Reside In Virtually All Post-Natal Organs And Tissues. J Cell Sci 2006; 119: 2204-2213
17. Tan S, Sagara Y, Liu Y, Maher P, Schubert D. The Regulation Of Reactive Oxygen Species Production During Programmed Cell Death. J Cell Biol 1998; 141: 1423-1432
18. Yamaguchi H, Wang Hg. The Protein Kinase Pkb/Akt Regulates Cell Survival And Apoptosis By Inhibiting Bax Conformational Change. Oncogene 2001; 20: 7779-7786
19. Haider H, Ashraf M. Strategies To Promote Donor Cell Survival: Combining Preconditioning Approach With Stem Cell Transplantation. J Mol Cell Cardiol 2008; 45: 554-566
20. Bourzac C, Smith Lc, Vincent P, Beauchamp G, Lavoie Jp, Laverty S. Isolation Of Equine Bone Marrow-Derived Mesenchymal Stem Cells: A Comparison Between Three Protocols. Equine Vet J 2010; 42: 519-527
21. Friedenstein Aj, Petrakova Kv, Kurolesova Ai, Frolova Gp. Heterotopic Of Bone Marrow. Analysis Of Precursor Cells For Osteogenic And Hematopoietic Tissues. Transplantation 1968; 6: 230-247
22. Robey Te, Saiget Mk, Reinecke H, Murry Ce. Systems Approaches To Preventing Transplanted Cell Death In Cardiac Repair. J Mol Cell Cardiol 2008; 45: 567-581
23. Cao Yj, Shibata T, Rainov Ng. Hypoxia-Inducible Transgene Expression In Differentiated Human Nt2N Neurons-A Cell Culture Model For Gene Therapy Of Postischemic Neuronal Loss. Gene Ther 2001; 8: 1357-1362
24. Wang G, Hazra Tk, Mitra S, Lee Hm, Englander Ew. Mitochondrial Dna Damage And A Hypoxic Response Are Induced By Cocl(2) In Rat Neuronal Pc12 Cells. Nucleic Acids Res 2000; 28: 2135-2140
25. Valko M, Leibfritz D, Moncol J, Cronin Mt, Mazur M, Telser J. Free Radicals And Antioxidants In Normal Physiological Functions And Human Disease. Int J Biochem Cell Biol 2007; 39: 44-84
26. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive Oxygen Species Promote Tnfalpha-Induced Death And Sustained Jnk Activation By Inhibiting Map Kinase Phosphatases. Cell 2005; 120: 649-661
27. Droge W. Free Radicals In The Physiological Control Of Cell Function. Physiol Rev 2002; 82: 47-95
28. Harrington Ha, Ho Kl, Ghosh S, Tung Kc. Construction And Analysis Of A Modular Model Of Caspase Activation In Apoptosis. Theor Biol Med Model 2008; 5: 26
29. Holzapfel Np, Holzapfel Bm, Champ S, Feldthusen J, Clements J, Hutmacher Dw. The Potential Role Of Lycopene For The Prevention And Therapy Of Prostate Cancer: From Molecular Mechanisms To Clinical Evidence. Int J Mol Sci 2013; 14: 14620-14646
30. Engelmann Nj, Clinton Sk, Erdman Jj. Nutritional Aspects Of Phytoene And Phytof Luene, Carotenoid Precursors To Lycopene. Adv Nutr 2011; 2: 51-61
31. Shi J, Le Maguer M. Lycopene In Tomatoes: Chemical And Physical Properties Affected By Food Processing. Crit Rev Food Sci Nutr 2000; 40: 1-42
32. Krinsky Ni. The Antioxidant And Biological Properties Of The Carotenoids. Ann N Y Acad Sci 1998; 854: 443-447
33. Di Mascio P, Kaiser S, Sies H. Lycopene As The Most Efficient Biological Carotenoid Singlet Oxygen Quencher. Arch Biochem Biophys 1989; 274: 532-538
34. Stambolic V, Woodgett Jr. Functional Distinctions Of Protein Kinase B/Akt Isoforms Defined By Their Influence On Cell Migration. Trends Cell Biol 2006; 16: 461-466
35. Downward J. Pi 3-Kinase, Akt And Cell Survival. Semin Cell Dev Biol 2004; 15: 177-182.