NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9348-9361

  Stanicka, Joanna ^a   Russell, Eileen G ^a   Woolley, John F ^a   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; CYTOLOGY; DISEASES; DNA; HYDROGEN PEROXIDE; OXIDATION; PEROXIDES; PROTEINS;

ACUTE MYELOID LEUKEMIA; DNA DOUBLE STRAND BREAKS; DOWN-REGULATION; GENOMIC INSTABILITY; INTERNAL TANDEM DUPLICATIONS; MOLECULAR BASIS; NUCLEAR MEMBRANES; REACTIVE OXYGEN SPECIES;

CELLS;

CD135 ANTIGEN; DYE; HYDROGEN PEROXIDE; ISOPROTEIN; MUTANT PROTEIN; NUCLEAR PEROXY EMERALD 1; PEROXY ORANGE 1; PHOSPHOPROTEIN; PROTEIN P22; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; 4'-N-BENZOYLSTAUROSPORINE; CYBA PROTEIN, HUMAN; FLT3 PROTEIN, HUMAN; NOX4 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; STAUROSPORINE;

32D CELL LINE; ACUTE GRANULOCYTIC LEUKEMIA; ANTIGEN EXPRESSION; ARTICLE; CELL LINE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DNA OXIDATION; DOUBLE STRANDED DNA BREAK; GENE SILENCING; GENETIC TRANSFECTION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MV4 11 CELL LINE; MYELOBLAST; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; WILD TYPE; ACUTE DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; CONFOCAL MICROSCOPY; DNA DAMAGE; DRUG EFFECTS; GENETICS; HL 60 CELL LINE; METABOLISM; MOUSE; MUTATION; MYELOID LEUKEMIA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TANDEM REPEAT; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; BLOTTING, WESTERN; CELL LINE; DNA DAMAGE; FMS-LIKE TYROSINE KINASE 3; GENOMIC INSTABILITY; HL-60 CELLS; HUMANS; HYDROGEN PEROXIDE; LEUKEMIA, MYELOID; MICE; MICROSCOPY, CONFOCAL; MUTATION; NADPH OXIDASE; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAUROSPORINE; TANDEM REPEAT SEQUENCES;

EID: 84927155756     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.510495     Document Type: Article

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