Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation

Oncotarget

Volumn 5, Issue 20, 2014, Pages 10034-10047

  Simioni, Carolina ^a   Cani, Alice ^a   Martelli, Alberto M ^b   Zauli, Giorgio ^c   Tabellini, Giovanna ^d   McCubrey, James ^e   Capitani, Silvano ^a   Neri, Luca M ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

^e EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Akt; B pre acute lymphoblastic leukemia; mTOR; Targeted therapy; Torin 2

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; DOXORUBICIN; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TEMSIROLIMUS; TORIN 2; UNCLASSIFIED DRUG; 9-(6-AMINOPYRIDIN-3-YL)-1-(3-(TRIFLUOROMETHYL)PHENYL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; FUSED HETEROCYCLIC RINGS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MTOR PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; NAPHTHYRIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG TARGETING; ENZYME REACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL LINE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; ENZYME ACTIVATION; EVEROLIMUS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MULTIPROTEIN COMPLEXES; NAPHTHYRIDINES; PHOSPHATIDYLINOSITOL 3-KINASES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84927147293     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2490     Document Type: Article

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