메뉴 건너뛰기




Volumn 103, Issue 1, 2014, Pages 118-125

CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition

Author keywords

Akt; Autophagy; CCT128930; Cell cycle; DNA damage

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; BECLIN 1; CASPASE 3; CASPASE 9; CCT 128930; CDC25A PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHLOROQUINE; CYCLIN D1; DNA; HISTONE H2AX; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN P21; PROTEIN P27; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 4-(4-CHLOROBENZYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDIN-4-AMINE; HISTONE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

EID: 84903720000     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.04.008     Document Type: Article
Times cited : (13)

References (28)
  • 1
    • 84856253626 scopus 로고    scopus 로고
    • Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: A fine balance
    • E. Aksamitiene, A. Kiyatkin, and B.N. Kholodenko Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance Biochem. Soc. Trans. 40 2012 139 146
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 139-146
    • Aksamitiene, E.1    Kiyatkin, A.2    Kholodenko, B.N.3
  • 2
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • J.A. Engelman, J. Luo, and L.C. Cantley The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nat. Rev. Genet. 7 2006 606 619
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 4
    • 84872370848 scopus 로고    scopus 로고
    • Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells
    • H.Y. Chang, M.H. Shih, H.C. Huang, S.R. Tsai, H.F. Juan, and S.C. Lee Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells PLoS One 8 2013 e54117
    • (2013) PLoS One , vol.8 , pp. 54117
    • Chang, H.Y.1    Shih, M.H.2    Huang, H.C.3    Tsai, S.R.4    Juan, H.F.5    Lee, S.C.6
  • 5
    • 84873658685 scopus 로고    scopus 로고
    • Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival
    • H.J. Cho, Y.J. Oh, S.H. Han, H.J. Chung, C.H. Kim, N.S. Lee, W.J. Kim, J.M. Choi, and H. Kim Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival J. Biol. Chem. 288 2013 3768 3776
    • (2013) J. Biol. Chem. , vol.288 , pp. 3768-3776
    • Cho, H.J.1    Oh, Y.J.2    Han, S.H.3    Chung, H.J.4    Kim, C.H.5    Lee, N.S.6    Kim, W.J.7    Choi, J.M.8    Kim, H.9
  • 6
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • J. Smith, L.M. Tho, N. Xu, and D.A. Gillespie The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer Adv. Cancer Res. 108 2010 73 112
    • (2010) Adv. Cancer Res. , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 7
    • 45849085731 scopus 로고    scopus 로고
    • Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation
    • A. Kulkarni, and K.C. Das Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation Am. J. Physiol. Lung Cell. Mol. Physiol. 294 2008 L998 L1006
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.294
    • Kulkarni, A.1    Das, K.C.2
  • 8
    • 29244484430 scopus 로고    scopus 로고
    • Radiation and new molecular agents part I: Targeting ATM-ATR checkpoints, DNA repair, and the proteasome
    • A. Choudhury, A. Cuddihy, and R.G. Bristow Radiation and new molecular agents part I: targeting ATM-ATR checkpoints, DNA repair, and the proteasome Semin. Radiat. Oncol. 16 2006 51 58
    • (2006) Semin. Radiat. Oncol. , vol.16 , pp. 51-58
    • Choudhury, A.1    Cuddihy, A.2    Bristow, R.G.3
  • 9
    • 80052697287 scopus 로고    scopus 로고
    • The role of autophagy in cancer: Therapeutic implications
    • Z.J. Yang, C.E. Chee, S. Huang, and F.A. Sinicrope The role of autophagy in cancer: therapeutic implications Mol. Cancer Ther. 10 2011 1533 1541
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1533-1541
    • Yang, Z.J.1    Chee, C.E.2    Huang, S.3    Sinicrope, F.A.4
  • 11
    • 84875615728 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk
    • C. Seitz, M. Hugle, S. Cristofanon, A. Tchoghandjian, and S. Fulda The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk Int. J. Cancer 132 2013 2682 2693
    • (2013) Int. J. Cancer , vol.132 , pp. 2682-2693
    • Seitz, C.1    Hugle, M.2    Cristofanon, S.3    Tchoghandjian, A.4    Fulda, S.5
  • 12
    • 84863832579 scopus 로고    scopus 로고
    • Development of PI3K/AKT/mTOR pathway inhibitors and their application in personalized therapy for non-small-cell lung cancer
    • V. Papadimitrakopoulou Development of PI3K/AKT/mTOR pathway inhibitors and their application in personalized therapy for non-small-cell lung cancer J. Thorac. Oncol. 7 2012 1315 1326
    • (2012) J. Thorac. Oncol. , vol.7 , pp. 1315-1326
    • Papadimitrakopoulou, V.1
  • 13
    • 78650636996 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway inhibitors in cancer: A perspective on clinical progress
    • P. Wu, and Y.Z. Hu PI3K/Akt/mTOR pathway inhibitors in cancer: a perspective on clinical progress Curr. Med. Chem. 17 2010 4326 4341
    • (2010) Curr. Med. Chem. , vol.17 , pp. 4326-4341
    • Wu, P.1    Hu, Y.Z.2
  • 14
    • 78650674698 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR inhibitors in ovarian cancer
    • M. Mazzoletti, and M. Broggini PI3K/AKT/mTOR inhibitors in ovarian cancer Curr. Med. Chem. 17 2010 4433 4447
    • (2010) Curr. Med. Chem. , vol.17 , pp. 4433-4447
    • Mazzoletti, M.1    Broggini, M.2
  • 15
    • 84866505616 scopus 로고    scopus 로고
    • Caudatin inhibits carcinomic human alveolar basal epithelial cell growth and angiogenesis through modulating GSK3β/β-catenin pathway
    • H.R. Fei, L.Y. Cui, Z.R. Zhang, Y. Zhao, and F.Z. Wang Caudatin inhibits carcinomic human alveolar basal epithelial cell growth and angiogenesis through modulating GSK3β/β-catenin pathway J. Cell. Biochem. 113 2012 3403 3410
    • (2012) J. Cell. Biochem. , vol.113 , pp. 3403-3410
    • Fei, H.R.1    Cui, L.Y.2    Zhang, Z.R.3    Zhao, Y.4    Wang, F.Z.5
  • 17
    • 84880573563 scopus 로고    scopus 로고
    • Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways
    • J. Wang, L. Yuan, H. Xiao, C. Xiao, Y. Wang, and X. Liu Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways Apoptosis 18 2013 751 765
    • (2013) Apoptosis , vol.18 , pp. 751-765
    • Wang, J.1    Yuan, L.2    Xiao, H.3    Xiao, C.4    Wang, Y.5    Liu, X.6
  • 18
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
    • Y. Shiloh, and Y. Ziv The ATM protein kinase: regulating the cellular response to genotoxic stress, and more Nat. Rev. Mol. Cell. Biol. 4 2013 197 210
    • (2013) Nat. Rev. Mol. Cell. Biol. , vol.4 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 19
    • 79955790090 scopus 로고    scopus 로고
    • Autophagy monitoring assay: Qualitative analysis of MAP LC3-I to II conversion by immunoblot
    • C.B. McLeland, J. Rodriguez, and S.T. Stern Autophagy monitoring assay: qualitative analysis of MAP LC3-I to II conversion by immunoblot Methods Mol. Biol. 697 2011 199 206
    • (2011) Methods Mol. Biol. , vol.697 , pp. 199-206
    • McLeland, C.B.1    Rodriguez, J.2    Stern, S.T.3
  • 22
    • 58149476936 scopus 로고    scopus 로고
    • Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways
    • S. Solier, O. Sordet, K.W. Kohn, and Y. Pommier Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways Mol. Cell. Biol. 29 2009 68 82
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 68-82
    • Solier, S.1    Sordet, O.2    Kohn, K.W.3    Pommier, Y.4
  • 23
    • 84866358168 scopus 로고    scopus 로고
    • The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
    • P. Bouwman, and J. Jonkers The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance Nat. Rev. Cancer 12 2012 587 598
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 587-598
    • Bouwman, P.1    Jonkers, J.2
  • 24
    • 84860298408 scopus 로고    scopus 로고
    • DNA damage response pathways and cell cycle checkpoints in colorectal cancer: Current concepts and future perspectives for targeted treatment
    • S. Solier, Y.W. Zhang, A. Ballestrero, Y. Pommier, and G. Zoppoli DNA damage response pathways and cell cycle checkpoints in colorectal cancer: current concepts and future perspectives for targeted treatment Curr. Cancer Drug. Targets 12 2012 356 371
    • (2012) Curr. Cancer Drug. Targets , vol.12 , pp. 356-371
    • Solier, S.1    Zhang, Y.W.2    Ballestrero, A.3    Pommier, Y.4    Zoppoli, G.5
  • 26
    • 84877323610 scopus 로고    scopus 로고
    • The impact of autophagic processes on the intracellular fate of Helicobacter pylori: More tricks from an enigmatic pathogen?
    • N.S. Deen, S.J. Huang, L. Gong, T. Kwok, and R.J. Devenish The impact of autophagic processes on the intracellular fate of Helicobacter pylori: more tricks from an enigmatic pathogen? Autophagy 9 2013 639 652
    • (2013) Autophagy , vol.9 , pp. 639-652
    • Deen, N.S.1    Huang, S.J.2    Gong, L.3    Kwok, T.4    Devenish, R.J.5
  • 28
    • 84862768394 scopus 로고    scopus 로고
    • Autophagy proteins in macroendocytic engulfment
    • O. Florey, and M. Overholtzer Autophagy proteins in macroendocytic engulfment Trends Cell. Biol. 22 2012 374 380
    • (2012) Trends Cell. Biol. , vol.22 , pp. 374-380
    • Florey, O.1    Overholtzer, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.