Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis

Leukemia

Volumn 28, Issue 11, 2014, Pages 2197-2205

  Bertacchini, J ^a   Guida, M ^b   Accordi, B ^b   Mediani, L ^a   Martelli, A M ^b   Barozzi, P ^b   Petricoin, E ^b   Liotta, L ^b   Milani, G ^b   Giordan, M ^b   Luppi, M ^b   Forghieri, F ^b   De Pol, A ^b   Cocco, L ^b   Basso, G ^b   Marmiroli, S ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN, HUMAN; AKT2 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; CARBANILAMIDE DERIVATIVE; INDOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEOME; PYRROLE DERIVATIVE; QUIZARTINIB; SUNITINIB; TARGET OF RAPAMYCIN KINASE;

ADULT; AGED; ANTAGONISTS AND INHIBITORS; APOPTOSIS; DRUG EFFECTS; DRUG POTENTIATION; FEEDBACK SYSTEM; HUMAN; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; PHYSIOLOGY; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOTHIAZOLES; DRUG SYNERGISM; FEEDBACK, PHYSIOLOGICAL; HUMANS; INDOLES; LEUKEMIA, MYELOID, ACUTE; MIDDLE AGED; PHENYLUREA COMPOUNDS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEOME; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RETROSPECTIVE STUDIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; YOUNG ADULT;

EID: 84922276285     PISSN: None     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.123     Document Type: Article

References (0)