The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy

Oncotarget

Volumn 4, Issue 9, 2013, Pages 1496-1506

  Simioni, Carolina ^a   Martelli, Alberto M ^b,c,d   Cani, Alice ^a   Cetin Atalay, Rengul ^e   McCubrey, James A ^f   Capitani, Silvano ^a   Neri, Luca M ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c CNR   (Italy)

^d RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^e BILKENT UNIVERSITY   (Turkey)

^f EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Akt 1; Apoptosis; Autophagy; Hepatocellular carcinoma; MK 2206; Targeted therapy

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; DOXORUBICIN; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN AKT 1; PROTEIN GSK3 ALPHA; PROTEIN GSK3 BETA; TRANSCRIPTION FACTOR FKHRL1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER CHEMOTHERAPY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; LIVER CELL CARCINOMA; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL GROWTH PROCESSES; DOXORUBICIN; DRUG SYNERGISM; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; LIVER NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 84884678640     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1236     Document Type: Article

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