SIRT1 inhibition in pancreatic cancer models: Contrasting effects in vitro and in vivo

European Journal of Pharmacology

Volumn 757, Issue , 2015, Pages 59-67

  Oon, Chern Ein ^a,b   Strell, Carina ^a   Yeong, Keng Yoon ^b   Östman, Arne ^a   Prakash, Jai ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

^c UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

EX527; Gemcitabine; Pancreatic cancer; SIRT1; Sirtuin; Tumour resistance

Indexed keywords

GEMCITABINE; SELISISTAT; SIRTUIN 1; 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE; CARBAZOLE DERIVATIVE; DEOXYCYTIDINE; HISTONE DEACETYLASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; SENESCENCE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL AGING; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MICRONUCLEUS TEST; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CARBAZOLES; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYCYTIDINE; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE INHIBITORS; HUMANS; MALE; MICE; MICRONUCLEUS TESTS; PANCREATIC NEOPLASMS; SIRTUIN 1;

EID: 84927143064     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.03.064     Document Type: Article

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