Involvement of mitochondria and caspase pathways in N-demethyl- clarithromycin-induced apoptosis in human cervical cancer HeLa cell

Acta Pharmacologica Sinica

Volumn 27, Issue 12, 2006, Pages 1622-1629

  Qiao, Ai Min ^a   Ikejima, Takashi ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Zhang, Wei Ge ^a   Wu, Ying Liang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Caspase; HeLa cells; Mitochondria; N demethyl clarithromycin

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8 INHIBITOR; CASPASE 9 INHIBITOR; CASPASE INHIBITOR; CELL NUCLEUS DNA; CLARITHROMYCIN DERIVATIVE; CYTOCHROME C; DEOXYRIBONUCLEASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NORCLARITHROMYCIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SIRTUIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DEGRADATION; DRUG CYTOTOXICITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL PROLIFERATION; CLARITHROMYCIN; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33751353596     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00444.x     Document Type: Article

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