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Volumn 15, Issue 8, 2014, Pages 521-527

Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; AMINOPEPTIDASE ER1; AMINOPEPTIDASE ER2; AMINOPEPTIDASE M1; HLA ANTIGEN CLASS 1; NPEPPS PROTEIN; UNCLASSIFIED DRUG; ERAP1 PROTEIN, HUMAN; ERAP2 PROTEIN, HUMAN; HLA ANTIGEN; METALLOPROTEINASE; NPEPPS PROTEIN, HUMAN;

EID: 84927133534     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2014.46     Document Type: Review
Times cited : (34)

References (65)
  • 2
    • 0027479821 scopus 로고
    • Evolutionary families of peptidases
    • Rawlings ND, Barrett AJ. Evolutionary families of peptidases. Biochem J. 1993; 290: 205-218.
    • (1993) Biochem J , vol.290 , pp. 205-218
    • Rawlings, N.D.1    Barrett, A.J.2
  • 3
    • 79956348710 scopus 로고    scopus 로고
    • Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
    • Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M et al. Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc Natl Acad Sci 2011; 108: 7745-7750.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 7745-7750
    • Kochan, G.1    Krojer, T.2    Harvey, D.3    Fischer, R.4    Chen, L.5    Vollmar, M.6
  • 4
    • 79955638487 scopus 로고    scopus 로고
    • Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
    • Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL et al. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol 2011; 18: 604-613.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 604-613
    • Nguyen, T.T.1    Chang, S.C.2    Evnouchidou, I.3    York, I.A.4    Zikos, C.5    Rock, K.L.6
  • 5
    • 84856935252 scopus 로고    scopus 로고
    • The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
    • Birtley JR, Saridakis E, Stratikos E, Mavridis IM. The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing. Biochemistry 2012; 51: 286-295.
    • (2012) Biochemistry , vol.51 , pp. 286-295
    • Birtley, J.R.1    Saridakis, E.2    Stratikos, E.3    Mavridis, I.M.4
  • 6
    • 4444367290 scopus 로고    scopus 로고
    • Membrane bound members of the M1 family: More than aminopeptidases
    • Albiston AL, Ye S, Chai SY. Membrane bound members of the M1 family: more than aminopeptidases. Protein Pept Lett 2004; 11: 491-500.
    • (2004) Protein Pept Lett , vol.11 , pp. 491-500
    • Albiston, A.L.1    Ye, S.2    Chai, S.Y.3
  • 7
    • 0033137055 scopus 로고    scopus 로고
    • Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity
    • Fukasawa KM, Fukasawa K, Harada M, Hirose J, Izumi T, Shimizu T. Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity. Biochem J 1999; 339: 497-502.
    • (1999) Biochem J , vol.339 , pp. 497-502
    • Fukasawa, K.M.1    Fukasawa, K.2    Harada, M.3    Hirose, J.4    Izumi, T.5    Shimizu, T.6
  • 9
    • 84915771682 scopus 로고    scopus 로고
    • A novel ERAP2 haplotype structure in a Chilean Population: Implications for ERAP2 protein expression and preeclampsia risk
    • Vanhille DL, Hill LD, Hilliard DD, Lee ED, Teves ME, Srinivas S et al. A novel ERAP2 haplotype structure in a Chilean Population: implications for ERAP2 protein expression and preeclampsia risk. Mol Genet Genomic Med 2013; 1: 98-107.
    • (2013) Mol Genet Genomic Med , vol.1 , pp. 98-107
    • Vanhille, D.L.1    Hill, L.D.2    Hilliard, D.D.3    Lee, E.D.4    Teves, M.E.5    Srinivas, S.6
  • 10
    • 36349025846 scopus 로고    scopus 로고
    • Association of antigen processing machinery and HLA class i defects with clinicopathological outcome in cervical carcinoma
    • Mehta AM, Jordanova ES, Kenter GG, Ferrone S, Fleuren GJ. Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma. Cancer Immunol Immunother 2008; 57: 197-206.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 197-206
    • Mehta, A.M.1    Jordanova, E.S.2    Kenter, G.G.3    Ferrone, S.4    Fleuren, G.J.5
  • 11
    • 65349123542 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma
    • Mehta AM, Jordanova ES, Corver WE, van Wezel T, Uh HW, Kenter GG et al. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. Genes Chromosomes Cancer 2009; 48: 410-418.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 410-418
    • Mehta, A.M.1    Jordanova, E.S.2    Corver, W.E.3    Van Wezel, T.4    Uh, H.W.5    Kenter, G.G.6
  • 12
    • 61849117976 scopus 로고    scopus 로고
    • Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    • Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H et al. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun 2009; 10: 188-191.
    • (2009) Genes Immun , vol.10 , pp. 188-191
    • Fung, E.Y.1    Smyth, D.J.2    Howson, J.M.3    Cooper, J.D.4    Walker, N.M.5    Stevens, H.6
  • 13
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    • Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, Leo P et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet 2013; 45: 730-738.
    • (2013) Nat Genet , vol.45 , pp. 730-738
    • Cortes, A.1    Hadler, J.2    Pointon, J.P.3    Robinson, P.C.4    Karaderi, T.5    Leo, P.6
  • 14
    • 33748070192 scopus 로고    scopus 로고
    • The genetic basis of ankylosing spondylitis
    • Reveille JD. The genetic basis of ankylosing spondylitis. Curr Opin Rheumatol 2006; 18: 332-341.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 332-341
    • Reveille, J.D.1
  • 15
    • 75749134196 scopus 로고    scopus 로고
    • Genetics of ankylosing spondylitis
    • Brown MA. Genetics of ankylosing spondylitis. Curr Opin Rheumatol 2010; 22: 126-132.
    • (2010) Curr Opin Rheumatol , vol.22 , pp. 126-132
    • Brown, M.A.1
  • 16
    • 78049347495 scopus 로고    scopus 로고
    • A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    • Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2
    • Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC, Knight J, Weale ME et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010; 42: 985-990.
    • (2010) Nat Genet , vol.42 , pp. 985-990
    • Strange, A.1    Capon, F.2    Spencer, C.C.3    Knight, J.4    Weale, M.E.5
  • 17
    • 84873091770 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B51 and ERAP1
    • Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E et al. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B51 and ERAP1. Nat Genet 2013; 45: 202-207.
    • (2013) Nat Genet , vol.45 , pp. 202-207
    • Kirino, Y.1    Bertsias, G.2    Ishigatsubo, Y.3    Mizuki, N.4    Tugal-Tutkun, I.5    Seyahi, E.6
  • 18
    • 84890213258 scopus 로고    scopus 로고
    • Genetics of Behçet's disease: Lessons learned from genomewide association studies
    • Gül A. Genetics of Behçet's disease: lessons learned from genomewide association studies. Curr Opin Rheumatol 2013; 26: 56-63.
    • (2013) Curr Opin Rheumatol , vol.26 , pp. 56-63
    • Gül, A.1
  • 20
    • 84878764878 scopus 로고    scopus 로고
    • Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes
    • Christodoulou K, Wiskin AE, Gibson J, Tapper W, Willis C, Afzal NA et al. Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes. Gut 2013; 62: 977-984.
    • (2013) Gut , vol.62 , pp. 977-984
    • Christodoulou, K.1    Wiskin, A.E.2    Gibson, J.3    Tapper, W.4    Willis, C.5    Afzal, N.A.6
  • 21
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett GC, Wang K, Radford-Smith GL, Ahmad T et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42: 1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, G.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 22
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondyloarthritis Consortium (TASC)
    • Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondyloarthritis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N et al. Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007; 39: 1329-1337.
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3    Craddock, N.4
  • 23
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet 2011; 43: 761-767.
    • (2011) Nat Genet , vol.43 , pp. 761-767
    • Evans, D.M.1    Spencer, C.C.2    Pointon, J.J.3    Su, Z.4    Harvey, D.5    Kochan, G.6
  • 24
    • 79551706070 scopus 로고    scopus 로고
    • ERAP1 is associated with ankylosing Spondylitis in Han Chinese
    • Li C, Lin Z, Xie Y, Guo Z, Huang J, Wei Q et al. ERAP1 is associated with ankylosing Spondylitis in Han Chinese. J Rheumatol 2011; 38: 317-321.
    • (2011) J Rheumatol , vol.38 , pp. 317-321
    • Li, C.1    Lin, Z.2    Xie, Y.3    Guo, Z.4    Huang, J.5    Wei, Q.6
  • 25
    • 76649083225 scopus 로고    scopus 로고
    • Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: The rs27044 variant is associated with HLA-B2705 subtype in Hungarian patients with ankylosing spondylitis
    • Pazar B, Safrany E, Gergely P, Szanto S, Szekanecz Z, Poor G. Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B2705 subtype in Hungarian patients with ankylosing spondylitis. J Rheumatol 2010; 37: 379-384.
    • (2010) J Rheumatol , vol.37 , pp. 379-384
    • Pazar, B.1    Safrany, E.2    Gergely, P.3    Szanto, S.4    Szekanecz, Z.5    Poor, G.6
  • 28
    • 84855168152 scopus 로고    scopus 로고
    • ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population
    • Szczypiorska M, Sanchez A, Bartolome N, Arteta D, Sanz J, Brito E et al. ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population. Rheumatology (Oxford) 2011; 50: 1969-1975.
    • (2011) Rheumatology (Oxford , vol.50 , pp. 1969-1975
    • Szczypiorska, M.1    Sanchez, A.2    Bartolome, N.3    Arteta, D.4    Sanz, J.5    Brito, E.6
  • 29
    • 78751706438 scopus 로고    scopus 로고
    • Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese
    • Davidson SI, Liu Y, Danoy PA, Wu X, Thomas GP, Jiang L et al. Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Ann Rheum Dis 2011; 70: 289-292.
    • (2011) Ann Rheum Dis , vol.70 , pp. 289-292
    • Davidson, S.I.1    Liu, Y.2    Danoy, P.A.3    Wu, X.4    Thomas, G.P.5    Jiang, L.6
  • 30
    • 70350525335 scopus 로고    scopus 로고
    • Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population
    • Davidson SI, Wu X, Liu Y, Wei M, Danoy PA, Thomas G et al. Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Arthritis Rheum 2009; 60: 3263-3268.
    • (2009) Arthritis Rheum , vol.60 , pp. 3263-3268
    • Davidson, S.I.1    Wu, X.2    Liu, Y.3    Wei, M.4    Danoy, P.A.5    Thomas, G.6
  • 31
    • 78049347495 scopus 로고    scopus 로고
    • A genomewide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    • Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH et al. A genomewide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010; 42: 985-990.
    • (2010) Nat Genet , vol.42 , pp. 985-990
    • Strange, A.1    Capon, F.2    Spencer, C.C.3    Knight, J.4    Weale, M.E.5    Allen, M.H.6
  • 32
    • 84878739093 scopus 로고    scopus 로고
    • Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
    • Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J et al. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet 2013; 45: 664-669.
    • (2013) Nat Genet , vol.45 , pp. 664-669
    • Hinks, A.1    Cobb, J.2    Marion, M.C.3    Prahalad, S.4    Sudman, M.5    Bowes, J.6
  • 33
    • 53049086918 scopus 로고    scopus 로고
    • CHR-2797: An antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells
    • Krige D, Needham LA, Bawden LJ, Flores N, Farmer H, Miles LE et al. CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res 2008; 68: 6669-6679.
    • (2008) Cancer Res , vol.68 , pp. 6669-6679
    • Krige, D.1    Needham, L.A.2    Bawden, L.J.3    Flores, N.4    Farmer, H.5    Miles, L.E.6
  • 35
    • 0036902105 scopus 로고    scopus 로고
    • An IFN-gammainduced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
    • Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL et al. An IFN-gammainduced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol 2002; 3: 1169-1176.
    • (2002) Nat Immunol , vol.3 , pp. 1169-1176
    • Saric, T.1    Chang, S.C.2    Hattori, A.3    York, I.A.4    Markant, S.5    Rock, K.L.6
  • 36
    • 0036884090 scopus 로고    scopus 로고
    • The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
    • York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL et al. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol 2002; 3: 1177-1184.
    • (2002) Nat Immunol , vol.3 , pp. 1177-1184
    • York, I.A.1    Chang, S.C.2    Saric, T.3    Keys, J.A.4    Favreau, J.M.5    Goldberg, A.L.6
  • 37
    • 54849426213 scopus 로고    scopus 로고
    • Evolutionary signatures of common human cisregulatory haplotypes
    • Ouyang C, Smith DD, Krontiris TG. Evolutionary signatures of common human cisregulatory haplotypes. PLoS ONE 2008; 3: e3362.
    • (2008) PLoS ONE , vol.3 , pp. e3362
    • Ouyang, C.1    Smith, D.D.2    Krontiris, T.G.3
  • 39
    • 79955638487 scopus 로고    scopus 로고
    • Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
    • Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL et al. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol 2011; 18: 604-613.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 604-613
    • Nguyen, T.T.1    Chang, S.C.2    Evnouchidou, I.3    York, I.A.4    Zikos, C.5    Rock, K.L.6
  • 40
    • 84877596051 scopus 로고    scopus 로고
    • Antigenic peptide trimming by ER aminopeptidases-insights from structural studies
    • Stratikos E, Stern LJ. Antigenic peptide trimming by ER aminopeptidases-insights from structural studies. Mol Immunol 2013; 55: 212-219.
    • (2013) Mol Immunol , vol.55 , pp. 212-219
    • Stratikos, E.1    Stern, L.J.2
  • 41
    • 56049109055 scopus 로고    scopus 로고
    • Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1
    • Goto Y, Tanji H, Hattori A, Tsujimoto M. Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1. Biochem J 2008; 416: 109-116.
    • (2008) Biochem J , vol.416 , pp. 109-116
    • Goto, Y.1    Tanji, H.2    Hattori, A.3    Tsujimoto, M.4
  • 43
    • 77955332608 scopus 로고    scopus 로고
    • Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential
    • Haroon N, Inman RD. Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential. Nat Rev Rheumatol 2010; 6: 461-467.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 461-467
    • Haroon, N.1    Inman, R.D.2
  • 44
    • 84860282102 scopus 로고    scopus 로고
    • Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2
    • Ascher DB, Polekhina G, Parker MW. Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012; 68: 468-471.
    • (2012) Acta Crystallogr Sect F Struct Biol Cryst Commun , vol.68 , pp. 468-471
    • Ascher, D.B.1    Polekhina, G.2    Parker, M.W.3
  • 45
    • 79953203538 scopus 로고    scopus 로고
    • Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides
    • Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M et al. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J 2011; 435: 411-420.
    • (2011) Biochem J , vol.435 , pp. 411-420
    • Zervoudi, E.1    Papakyriakou, A.2    Georgiadou, D.3    Evnouchidou, I.4    Gajda, A.5    Poreba, M.6
  • 46
    • 22144442460 scopus 로고    scopus 로고
    • Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
    • Saveanu L, Carroll O, Lindo V, Del Val M, Lopez D, Lepelletier Y et al. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol 2005; 6: 689-697.
    • (2005) Nat Immunol , vol.6 , pp. 689-697
    • Saveanu, L.1    Carroll, O.2    Lindo, V.3    Del Val, M.4    Lopez, D.5    Lepelletier, Y.6
  • 47
    • 78449233933 scopus 로고    scopus 로고
    • Balancing selection maintains a form of ERAP2 that undergoes nonsensemediated decay and affects antigen presentation
    • Andres AM, Dennis MY, Kretzschmar WW, Cannons JL, Lee-Lin SQ, Hurle B et al. Balancing selection maintains a form of ERAP2 that undergoes nonsensemediated decay and affects antigen presentation. PLoS Genet 2010; 6: e1001157.
    • (2010) PLoS Genet , vol.6 , pp. e1001157
    • Andres, A.M.1    Dennis, M.Y.2    Kretzschmar, W.W.3    Cannons, J.L.4    Lee-Lin, S.Q.5    Hurle, B.6
  • 48
    • 84865421949 scopus 로고    scopus 로고
    • A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing
    • Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M et al. A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing. J Immunol 2012; 189: 2383-2392.
    • (2012) J Immunol , vol.189 , pp. 2383-2392
    • Evnouchidou, I.1    Birtley, J.2    Seregin, S.3    Papakyriakou, A.4    Zervoudi, E.5    Samiotaki, M.6
  • 49
    • 0023743331 scopus 로고
    • Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases
    • McLellan S, Dyer SH, Rodriguez G, Hersh LB. Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases. J Neurochem 1988; 51: 1552-1559.
    • (1988) J Neurochem , vol.51 , pp. 1552-1559
    • McLellan, S.1    Dyer, S.H.2    Rodriguez, G.3    Hersh, L.B.4
  • 50
    • 0025057536 scopus 로고
    • Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat
    • Dyer SH, Slaughter CA, Orth K, Moomaw CR, Hersh LB. Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat. J Neurochem 1990; 54: 547-554.
    • (1990) J Neurochem , vol.54 , pp. 547-554
    • Dyer, S.H.1    Slaughter, C.A.2    Orth, K.3    Moomaw, C.R.4    Hersh, L.B.5
  • 51
    • 0025181826 scopus 로고
    • Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase
    • Johnson GD, Hersh LB. Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase. Arch Biochem Biophys 1990; 276: 305-309.
    • (1990) Arch Biochem Biophys , vol.276 , pp. 305-309
    • Johnson, G.D.1    Hersh, L.B.2
  • 52
    • 0029046205 scopus 로고
    • Degradation of dynorphin-related peptides by the puromycinsensitive aminopeptidase and aminopeptidase M
    • Safavi A, Hersh LB. Degradation of dynorphin-related peptides by the puromycinsensitive aminopeptidase and aminopeptidase M. J Neurochem 1995; 65: 389-395.
    • (1995) J Neurochem , vol.65 , pp. 389-395
    • Safavi, A.1    Hersh, L.B.2
  • 53
    • 79954492611 scopus 로고    scopus 로고
    • Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice
    • Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z et al. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Hum Mol Genet 2011; 20: 1820-1833.
    • (2011) Hum Mol Genet , vol.20 , pp. 1820-1833
    • Kudo, L.C.1    Parfenova, L.2    Ren, G.3    Vi, N.4    Hui, M.5    Ma, Z.6
  • 54
    • 0037447922 scopus 로고    scopus 로고
    • Mutation of active site residues of the puromycin-sensitive aminopeptidase: Conversion of the enzyme into a catalytically inactive binding protein
    • Thompson MW, Govindaswami M, Hersh LB. Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. Arch Biochem Biophys 2003; 413: 236-242.
    • (2003) Arch Biochem Biophys , vol.413 , pp. 236-242
    • Thompson, M.W.1    Govindaswami, M.2    Hersh, L.B.3
  • 55
    • 84857924158 scopus 로고    scopus 로고
    • Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis
    • Haroon N, Tsui FW, Uchanska-Ziegler B, Ziegler A, Inman RD. Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis. Ann Rheum Dis 2012; 71: 589-595.
    • (2012) Ann Rheum Dis , vol.71 , pp. 589-595
    • Haroon, N.1    Tsui, F.W.2    Uchanska-Ziegler, B.3    Ziegler, A.4    Inman, R.D.5
  • 56
    • 84884413079 scopus 로고    scopus 로고
    • ERAP1 structure function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases
    • Alvarez-Navarro C, López de Castro JA. ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases. Mol Immunol 2013; 57 (1): 12-21.
    • (2013) Mol Immunol , vol.57 , Issue.1 , pp. 12-21
    • Alvarez-Navarro, C.1    López De Castro, J.A.2
  • 57
    • 84869219870 scopus 로고    scopus 로고
    • Functional interaction of the ankylosing spondylitisassociated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo
    • Garciá-Medel N, Sanz-Bravo A, Van Nguyen D, Galocha B, Gómez-Molina P, Martín-Esteban A et al. Functional interaction of the ankylosing spondylitisassociated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo. Mol Cell Proteomics 2012; 11: 1416-1429.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 1416-1429
    • Garciá-Medel, N.1    Sanz-Bravo, A.2    Van Nguyen, D.3    Galocha, B.4    Gómez-Molina, P.5    Martín-Esteban, A.6
  • 58
    • 84894192415 scopus 로고    scopus 로고
    • Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands
    • Martín-Esteban A, Gómez-Molina P, Sanz-Bravo A, López de Castro J. Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands. J Biol Chem 2014; 289: 3978-3990.
    • (2014) J Biol Chem , vol.289 , pp. 3978-3990
    • Martín-Esteban, A.1    Gómez-Molina, P.2    Sanz-Bravo, A.3    López De Castro, J.4
  • 59
    • 84879883082 scopus 로고    scopus 로고
    • ERAP1 in ankylosing spondylitis: Genetics, biology and pathogenetic role
    • Alvarez-Navarro C, López de Castro J. ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role. Curr Opin Rheumatol 2013; 25: 419-425.
    • (2013) Curr Opin Rheumatol , vol.25 , pp. 419-425
    • Alvarez-Navarro, C.1    López De Castro, J.2
  • 60
    • 84896269583 scopus 로고    scopus 로고
    • Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27
    • Chen L, Fischer R, Peng Y, Reeves E, McHugh K, Ternette N et al. Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27. Arthritis Rheumatol 2014; 66: 284-294.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 284-294
    • Chen, L.1    Fischer, R.2    Peng, Y.3    Reeves, E.4    McHugh, K.5    Ternette, N.6
  • 61
    • 84902180272 scopus 로고    scopus 로고
    • HLA-B27, but not HLA-B7, immunodominance to Influenza is ERAP dependent
    • Akram A, Lin A, Gracey E, Streutker CJ, Inman RD. HLA-B27, but not HLA-B7, immunodominance to Influenza is ERAP dependent. J Immunol 2014; 192 (12): 5520-5528.
    • (2014) J Immunol , vol.192 , Issue.12 , pp. 5520-5528
    • Akram, A.1    Lin, A.2    Gracey, E.3    Streutker, C.J.4    Inman, R.D.5
  • 62
    • 84896917553 scopus 로고    scopus 로고
    • Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection
    • Akram A, Inman RD. Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection. Eur J Immunol 2013; 43: 3254-3267.
    • (2013) Eur J Immunol , vol.43 , pp. 3254-3267
    • Akram, A.1    Inman, R.D.2
  • 63
    • 85028195332 scopus 로고    scopus 로고
    • Fine-mapping major histocompatibility complex variation associated with ankylosing spondylitis susceptibility
    • Cortes A, de Bakker P, Brown MA. Fine-mapping major histocompatibility complex variation associated with ankylosing spondylitis susceptibility. In American College of Rheumatology. Arthritis Rheum 2013; 12: 1706.
    • (2013) American College of Rheumatology. Arthritis Rheum , vol.12 , pp. 1706
    • Cortes, A.1    De Bakker, P.2    Brown, M.A.3
  • 64
    • 57349101001 scopus 로고    scopus 로고
    • Identification and characterization of a new cognitive enhancer based on inhibition of insulinregulated aminopeptidase
    • Albiston AL, Morton CJ, Ng HL, Pham V, Yeatman HR, Ye S et al. Identification and characterization of a new cognitive enhancer based on inhibition of insulinregulated aminopeptidase. FASEB J 2008; 22: 4209-4217.
    • (2008) FASEB J , vol.22 , pp. 4209-4217
    • Albiston, A.L.1    Morton, C.J.2    Ng, H.L.3    Pham, V.4    Yeatman, H.R.5    Ye, S.6
  • 65
    • 0023668235 scopus 로고
    • L-lysinethiol: A subnanomolar inhibitor of aminopeptidase B
    • Ocain TD, Rich DH. L-lysinethiol: a subnanomolar inhibitor of aminopeptidase B. Biochem Biophys Res Commun 1987; 145: 1038-1042.
    • (1987) Biochem Biophys Res Commun , vol.145 , pp. 1038-1042
    • Ocain, T.D.1    Rich, D.H.2


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