Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho Family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9363-9376

  Stankiewicz, Trisha R ^a,b   Ramaswami, Sai Anandi ^b   Bouchard, Ron J ^a   Aktories, Klaus ^c   Linseman, Daniel A ^a,b,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF DENVER   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; ENZYME ACTIVITY; ENZYMES; PROTEINS;

CEREBELLAR GRANULE NEURONS; CLOSTRIDIUM DIFFICILE; CONSTITUTIVELY ACTIVES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MITOGEN ACTIVATED PROTEIN KINASE; NEURONAL DIFFERENTIATION; P-21 ACTIVATED KINASE; SELECTIVE INHIBITORS;

NEURONS;

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ADENOVIRUS VECTOR; BH3 PROTEIN; BIM PROTEIN; CASPASE 3; CASPASE INHIBITOR; CLOSTRIDIUM DIFFICILE TOXIN B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5; P21 ACTIVATED KINASE; PROTEIN BAD; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN P90; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; AMINOQUINOLINE DERIVATIVE; BACTERIAL PROTEIN; BACTERIAL TOXIN; BAD PROTEIN, RAT; MAP2K5 PROTEIN, RAT; PYRIMIDINE DERIVATIVE; S6 KINASE; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CEREBELLAR GRANULE NEURON; CEREBELLUM CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; MALE; MITOCHONDRION; NERVE CELL; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CEREBELLUM; CYTOLOGY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

CLOSTRIDIUM DIFFICILE;

AMINOQUINOLINES; ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BCL-ASSOCIATED DEATH PROTEIN; CELLS, CULTURED; CEREBELLUM; FEMALE; IMMUNOBLOTTING; MALE; MAP KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 7; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RAC GTP-BINDING PROTEINS; RATS, SPRAGUE-DAWLEY; RHO GTP-BINDING PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION;

EID: 84927130666     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.575217     Document Type: Article

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