Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca2+ release from the endoplasmic reticulum

Journal of Neurochemistry

Volumn 133, Issue 3, 2015, Pages 309-319

  Guerra Álvarez, María ^a   Moreno Ortega, Ana J ^a,b,c   Navarro, Elisa ^b,c   Fernández Morales, José Carlos ^b,c   Egea, Javier ^a,b,c   Lõpez, Manuela G ^a,b,c   Cano Abad, María F ^a,b,c  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Ca2+; cytotoxicity; D1 ER cameleon probe; positive allosteric modulators; 7 nicotinic receptors

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYL 3 ISOXAZOLYL)UREA; BUNGAROTOXIN RECEPTOR; FURA 2; 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-METHYLISOXAZOL-3-YL)UREA; CALCIUM; CARBANILAMIDE DERIVATIVE; ISOXAZOLE DERIVATIVE;

ADULT; ALLOSTERISM; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; MALE; MTT ASSAY; NEUROBLASTOMA CELL LINE; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STAINING; AGONISTS; ANIMAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

RATTUS;

ALLOSTERIC REGULATION; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; CALCIUM; CELL DEATH; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HUMANS; ISOXAZOLES; MALE; PHENYLUREA COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84927129932     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13049     Document Type: Article

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