-
1
-
-
0028278717
-
Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity
-
Akaike A, Tamura Y, Yokota T, Shimohama S, Kimura J (1994) Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Res 644:181-187.
-
(1994)
Brain Res
, vol.644
, pp. 181-187
-
-
Akaike, A.1
Tamura, Y.2
Yokota, T.3
Shimohama, S.4
Kimura, J.5
-
2
-
-
0033846277
-
Central nicotinic receptors, neurotrophic factors and neuroprotection
-
Belluardo N, Mudo G, Blum M, Fuxe K (2000) Central nicotinic receptors, neurotrophic factors and neuroprotection. Behav Brain Res 113:21-34.
-
(2000)
Behav Brain Res
, vol.113
, pp. 21-34
-
-
Belluardo, N.1
Mudo, G.2
Blum, M.3
Fuxe, K.4
-
3
-
-
0028972774
-
Nicotine protects against systemic kainic acid-induced excitotoxic effects
-
Borlongan CV, Shytle RD, Ross SD, Shimizu T, Freeman TB, Cahill DW, Sanberg PR (1995) Nicotine protects against systemic kainic acid-induced excitotoxic effects. Exp Neurol 136:261-265.
-
(1995)
Exp Neurol
, vol.136
, pp. 261-265
-
-
Borlongan, C.V.1
Shytle, R.D.2
Ross, S.D.3
Shimizu, T.4
Freeman, T.B.5
Cahill, D.W.6
Sanberg, P.R.7
-
4
-
-
0031970726
-
Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway
-
Carlson NG, Bacchi A, Rogers SW, Gahring LC (1998) Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway. J Neurobiol 35:29-36.
-
(1998)
J Neurobiol
, vol.35
, pp. 29-36
-
-
Carlson, N.G.1
Bacchi, A.2
Rogers, S.W.3
Gahring, L.C.4
-
5
-
-
0035819054
-
Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons
-
Chang KT, Berg DK (2001) Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron 32:855-865.
-
(2001)
Neuron
, vol.32
, pp. 855-865
-
-
Chang, K.T.1
Berg, D.K.2
-
6
-
-
0033626560
-
The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca(2+) dependent mechanism
-
Dajas-Bailador FA, Lima PA, Wonnacott S (2000) The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca(2+) dependent mechanism. Neuropharmacology 39:2799-2807.
-
(2000)
Neuropharmacology
, vol.39
, pp. 2799-2807
-
-
Dajas-Bailador, F.A.1
Lima, P.A.2
Wonnacott, S.3
-
7
-
-
0036488178
-
Nicotine activates the extracellular signal-regulated kinase 1/2 via the alpha7 nicotinic acetylcholine receptor and protein kinase A, in SH-SY5Y cells and hippocampal neurones
-
Dajas-Bailador FA, Soliakov L, Wonnacott S (2002) Nicotine activates the extracellular signal-regulated kinase 1/2 via the alpha7 nicotinic acetylcholine receptor and protein kinase A, in SH-SY5Y cells and hippocampal neurones. J Neurochem 80:520-530.
-
(2002)
J Neurochem
, vol.80
, pp. 520-530
-
-
Dajas-Bailador, F.A.1
Soliakov, L.2
Wonnacott, S.3
-
8
-
-
0027855978
-
Involvement of calcium and L-type channels in nicotine-induced antinociception
-
Damaj MI, Welch SP, Martin BR (1993) Involvement of calcium and L-type channels in nicotine-induced antinociception. J Pharmacol Exp Ther 266:1330-1338.
-
(1993)
J Pharmacol Exp Ther
, vol.266
, pp. 1330-1338
-
-
Damaj, M.I.1
Welch, S.P.2
Martin, B.R.3
-
9
-
-
0027453536
-
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
-
Dawson TM, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH (1993) Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci USA 90:9808-9812.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9808-9812
-
-
Dawson, T.M.1
Steiner, J.P.2
Dawson, V.L.3
Dinerman, J.L.4
Uhl, G.R.5
Snyder, S.H.6
-
10
-
-
0036086484
-
Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade
-
Day M, Olson PA, Platzer J, Striessnig J, Surmeier DJ (2002) Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade. J Neurophysiol 87:2490-2504.
-
(2002)
J Neurophysiol
, vol.87
, pp. 2490-2504
-
-
Day, M.1
Olson, P.A.2
Platzer, J.3
Striessnig, J.4
Surmeier, D.J.5
-
11
-
-
0032586886
-
Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C
-
Fenster CP, Beckman ML, Parker JC, Sheffield EB, Whitworth TL, Quick MW, Lester RA (1999) Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C. Mol Pharmacol 55:432-443.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 432-443
-
-
Fenster, C.P.1
Beckman, M.L.2
Parker, J.C.3
Sheffield, E.B.4
Whitworth, T.L.5
Quick, M.W.6
Lester, R.A.7
-
12
-
-
0033842094
-
Smoking and Parkinson's and Alzheimer's disease: Review of the epidemiological studies
-
Fratiglioni L, Wang HX (2000) Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies. Behav Brain Res 113:117-120.
-
(2000)
Behav Brain Res
, vol.113
, pp. 117-120
-
-
Fratiglioni, L.1
Wang, H.X.2
-
13
-
-
0037472775
-
Mapping of presynaptic nicotinic acetylcholine receptors using fluorescence imaging of neuritic calcium
-
Girod R, Jareb M, Moss J, Role L (2003) Mapping of presynaptic nicotinic acetylcholine receptors using fluorescence imaging of neuritic calcium. J Neurosci Methods 122:109-122.
-
(2003)
J Neurosci Methods
, vol.122
, pp. 109-122
-
-
Girod, R.1
Jareb, M.2
Moss, J.3
Role, L.4
-
14
-
-
0034961705
-
Neuroimmunophilins: Novel neuroprotective and neuroregenerative targets
-
Guo X, Dillman III JF, Dawson VL, Dawson TM (2001) Neuroimmunophilins: novel neuroprotective and neuroregenerative targets. Ann Neurol 50:6-16.
-
(2001)
Ann Neurol
, vol.50
, pp. 6-16
-
-
Guo, X.1
Dillman J.F. III2
Dawson, V.L.3
Dawson, T.M.4
-
16
-
-
0033485390
-
Nicotinic receptors in the brain: Correlating physiology with function
-
Jones S, Sudweeks S, Yakel JL (1999) Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci 22:555-561.
-
(1999)
Trends Neurosci
, vol.22
, pp. 555-561
-
-
Jones, S.1
Sudweeks, S.2
Yakel, J.L.3
-
17
-
-
0030827671
-
Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors
-
Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, Kimura J (1997) Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors. Brain Res 765:135-140.
-
(1997)
Brain Res
, vol.765
, pp. 135-140
-
-
Kaneko, S.1
Maeda, T.2
Kume, T.3
Kochiyama, H.4
Akaike, A.5
Shimohama, S.6
Kimura, J.7
-
18
-
-
0037092335
-
Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels
-
Khiroug SS, Harkness PC, Lamb PW, Sudweeks SN, Khiroug L, Millar NS, Yakel JL (2002) Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels. J Physiol (Lond) 540:425-434.
-
(2002)
J Physiol (Lond)
, vol.540
, pp. 425-434
-
-
Khiroug, S.S.1
Harkness, P.C.2
Lamb, P.W.3
Sudweeks, S.N.4
Khiroug, L.5
Millar, N.S.6
Yakel, J.L.7
-
19
-
-
0032507506
-
Stimulation of alpha-4-beta-2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity
-
Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A (1998) Stimulation of alpha-4-beta-2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. Brain Res 792:331-334.
-
(1998)
Brain Res
, vol.792
, pp. 331-334
-
-
Kihara, T.1
Shimohama, S.2
Urushitani, M.3
Sawada, H.4
Kimura, J.5
Kume, T.6
Maeda, T.7
Akaike, A.8
-
20
-
-
0035957946
-
Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity
-
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (2001) Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276:13541-13546.
-
(2001)
J Biol Chem
, vol.276
, pp. 13541-13546
-
-
Kihara, T.1
Shimohama, S.2
Sawada, H.3
Honda, K.4
Nakamizo, T.5
Shibasaki, H.6
Kume, T.7
Akaike, A.8
-
21
-
-
0036282745
-
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
-
Konishi Y, Lehtinen M, Donovan N, Bonni A (2002) Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell 9:1005-1016.
-
(2002)
Mol Cell
, vol.9
, pp. 1005-1016
-
-
Konishi, Y.1
Lehtinen, M.2
Donovan, N.3
Bonni, A.4
-
22
-
-
0036517068
-
Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries
-
Laudenbach V, Medja F, Zoli M, Rossi F, Evrard P, Changeux J, Gressens P (2002) Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries. FASEB J 16:423-435.
-
(2002)
FASEB J
, vol.16
, pp. 423-435
-
-
Laudenbach, V.1
Medja, F.2
Zoli, M.3
Rossi, F.4
Evrard, P.5
Changeux, J.6
Gressens, P.7
-
23
-
-
0024341227
-
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory
-
Lisman J (1989) A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc Natl Acad Sci USA 86:9574-9578.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 9574-9578
-
-
Lisman, J.1
-
24
-
-
0032527697
-
Calcineurin involvement in the regulation of high-threshold Ca2+ channels in NG108-15 (rodent neuroblastoma × glioma hybrid) cells
-
Lukyanetz EA, Piper TP, Sihra TS (1998) Calcineurin involvement in the regulation of high-threshold Ca2+ channels in NG108-15 (rodent neuroblastoma × glioma hybrid) cells. J Physiol (Lond) 510:371-385.
-
(1998)
J Physiol (Lond)
, vol.510
, pp. 371-385
-
-
Lukyanetz, E.A.1
Piper, T.P.2
Sihra, T.S.3
-
25
-
-
0033578855
-
Long-term potentiation-a decade of progress?
-
Malenka RC, Nicoll RA (1999) Long-term potentiation-a decade of progress? Science 285:1870-1874.
-
(1999)
Science
, vol.285
, pp. 1870-1874
-
-
Malenka, R.C.1
Nicoll, R.A.2
-
26
-
-
0028059643
-
Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity
-
Marin P, Maus M, Desagher S, Glowinski J, Premont J (1994) Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity. NeuroReport 5:1977-1980.
-
(1994)
NeuroReport
, vol.5
, pp. 1977-1980
-
-
Marin, P.1
Maus, M.2
Desagher, S.3
Glowinski, J.4
Premont, J.5
-
28
-
-
0024347735
-
Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones
-
Mayer ML, Vyklicky Jr L, Westbrook GL (1989) Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones. J Physiol (Lond) 415:329-350.
-
(1989)
J Physiol (Lond)
, vol.415
, pp. 329-350
-
-
Mayer, M.L.1
Vyklicky L., Jr.2
Westbrook, G.L.3
-
30
-
-
0037192850
-
Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor
-
Meyer EL, Gahring LC, Rogers SW (2002) Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor. J Biol Chem 277:10869-10875.
-
(2002)
J Biol Chem
, vol.277
, pp. 10869-10875
-
-
Meyer, E.L.1
Gahring, L.C.2
Rogers, S.W.3
-
31
-
-
17144413330
-
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
-
Picciotto MR, Zoli M, Léna C, Bessis A, Lallemand Y, LeNovčre N, Vincent P, Pich EM, Brulet P, Changeux JP (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374:65-67.
-
(1995)
Nature
, vol.374
, pp. 65-67
-
-
Picciotto, M.R.1
Zoli, M.2
Léna, C.3
Bessis, A.4
Lallemand, Y.5
LeNovčre, N.6
Vincent, P.7
Pich, E.M.8
Brulet, P.9
Changeux, J.P.10
-
32
-
-
0035726679
-
Neuronal nicotinic acetylcholine receptor subunit knockout mice: Physiological and behavioral phenotypes and possible clinical implications
-
Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, King SL (2001) Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther 92:89-108.
-
(2001)
Pharmacol Ther
, vol.92
, pp. 89-108
-
-
Picciotto, M.R.1
Caldarone, B.J.2
Brunzell, D.H.3
Zachariou, V.4
Stevens, T.R.5
King, S.L.6
-
34
-
-
0032953731
-
If phosphatases go up, memory goes down
-
Riedel G (1999) If phosphatases go up, memory goes down. Cell Mol Life Sci 55:549-553.
-
(1999)
Cell Mol Life Sci
, vol.55
, pp. 549-553
-
-
Riedel, G.1
-
35
-
-
0035036071
-
Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice
-
Ryan RE, Ross SA, Drago J, Loiacono RE (2001) Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice. Br J Pharmacol 132:1650-1656.
-
(2001)
Br J Pharmacol
, vol.132
, pp. 1650-1656
-
-
Ryan, R.E.1
Ross, S.A.2
Drago, J.3
Loiacono, R.E.4
-
36
-
-
0035957403
-
Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores
-
Sharma G, Vijayaraghavan S (2001) Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores. Proc Natl Acad Sci USA 98:4148-4153.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4148-4153
-
-
Sharma, G.1
Vijayaraghavan, S.2
-
37
-
-
0033638106
-
Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents
-
Shi J, Townsend M, Constantine-Paton M (2000) Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents. Neuron 28:103-114.
-
(2000)
Neuron
, vol.28
, pp. 103-114
-
-
Shi, J.1
Townsend, M.2
Constantine-Paton, M.3
-
38
-
-
0032055648
-
Identification of a signaling pathway involved in calcium regulation of BDNF expression
-
Shieh PB, Hu SC, Bobb K, Timmusk T, Ghosh A (1998) Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20:727-740.
-
(1998)
Neuron
, vol.20
, pp. 727-740
-
-
Shieh, P.B.1
Hu, S.C.2
Bobb, K.3
Timmusk, T.4
Ghosh, A.5
-
39
-
-
0029923226
-
Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation
-
Shimohama S, Akaike A, Kimura J (1996) Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation. Ann NY Acad Sci 777:356-361.
-
(1996)
Ann NY Acad Sci
, vol.777
, pp. 356-361
-
-
Shimohama, S.1
Akaike, A.2
Kimura, J.3
-
40
-
-
0035117942
-
Synaptically driven calcium transients via nicotinic receptors on somatic spines
-
Shoop RD, Chang KT, Ellisman MH, Berg DK (2001) Synaptically driven calcium transients via nicotinic receptors on somatic spines. J Neurosci 21:771-781.
-
(2001)
J Neurosci
, vol.21
, pp. 771-781
-
-
Shoop, R.D.1
Chang, K.T.2
Ellisman, M.H.3
Berg, D.K.4
-
41
-
-
0036469388
-
Ultrastructure of a somatic spine mat for nicotinic signaling in neurons
-
Shoop RD, Esquenazi E, Yamada N, Ellisman MH, Berg DK (2002) Ultrastructure of a somatic spine mat for nicotinic signaling in neurons. J Neurosci 22:748-756.
-
(2002)
J Neurosci
, vol.22
, pp. 748-756
-
-
Shoop, R.D.1
Esquenazi, E.2
Yamada, N.3
Ellisman, M.H.4
Berg, D.K.5
-
42
-
-
0032034262
-
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
-
Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME (1998) Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20:709-726.
-
(1998)
Neuron
, vol.20
, pp. 709-726
-
-
Tao, X.1
Finkbeiner, S.2
Arnold, D.B.3
Shaywitz, A.J.4
Greenberg, M.E.5
-
43
-
-
0033916075
-
Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta
-
Tsuneki H, Klink R, Léna C, Korn H, Changeux JP (2000) Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta. Eur J Neurosci 12:2475-2485.
-
(2000)
Eur J Neurosci
, vol.12
, pp. 2475-2485
-
-
Tsuneki, H.1
Klink, R.2
Léna, C.3
Korn, H.4
Changeux, J.P.5
-
44
-
-
0026559614
-
Nicotinic receptors that bind alpha-bungarotoxin on neurons raise intracellular free Ca2+
-
Vijayaraghavan S, Pugh PC, Zhang ZW, Rathouz MM, Berg DK (1992) Nicotinic receptors that bind alpha-bungarotoxin on neurons raise intracellular free Ca2+. Neuron 8:353-362.
-
(1992)
Neuron
, vol.8
, pp. 353-362
-
-
Vijayaraghavan, S.1
Pugh, P.C.2
Zhang, Z.W.3
Rathouz, M.M.4
Berg, D.K.5
-
45
-
-
0033537768
-
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
-
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (1999) Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284:339-343.
-
(1999)
Science
, vol.284
, pp. 339-343
-
-
Wang, H.G.1
Pathan, N.2
Ethell, I.M.3
Krajewski, S.4
Yamaguchi, Y.5
Shibasaki, F.6
McKeon, F.7
Bobo, T.8
Franke, T.F.9
Reed, J.C.10
-
46
-
-
0033118612
-
Smoking and the occurrence of Alzheimer's disease: Cross-sectional and longitudinal data in a population-based study
-
Wang HX, Fratiglioni L, Frisoni GB, Viitanen M, Winblad B (1999) Smoking and the occurrence of Alzheimer's disease: cross-sectional and longitudinal data in a population-based study. Am J Epidemiol 149:640-644.
-
(1999)
Am J Epidemiol
, vol.149
, pp. 640-644
-
-
Wang, H.X.1
Fratiglioni, L.2
Frisoni, G.B.3
Viitanen, M.4
Winblad, B.5
-
47
-
-
0030887172
-
Calcineurin regulation of synaptic function: From ion channels to transmitter release and gene transcription
-
Yakel JL (1997) Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription. Trends Pharmacol Sci 18:124-134.
-
(1997)
Trends Pharmacol Sci
, vol.18
, pp. 124-134
-
-
Yakel, J.L.1
-
48
-
-
0033104499
-
Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors
-
Zoli M, Picciotto MR, Ferrari R, Cocchi D, Changeux JP (1999) Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. EMBO J 18:1235-1244.
-
(1999)
EMBO J
, vol.18
, pp. 1235-1244
-
-
Zoli, M.1
Picciotto, M.R.2
Ferrari, R.3
Cocchi, D.4
Changeux, J.P.5
|