Precise engineering of dapivirine-loaded nanoparticles for the development of anti-HIV vaginal microbicides

Acta Biomaterialia

Volumn 18, Issue , 2015, Pages 77-87

  Das Neves, José ^a   Sarmento, Bruno ^a  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

Author keywords

Cytotoxicity; Mucin; Poly(d,l lactic co glycolic acid); Response surface methodology; Vaginal drug delivery

Indexed keywords

CELL CULTURE; CELLS; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DESIGN OF EXPERIMENTS; DRUG PRODUCTS; EMULSIFICATION; FLUORESCENCE MICROSCOPY; MONOLAYERS; TARGETED DRUG DELIVERY;

ANTI-HIV; CELL MONOLAYERS; DRUG RELEASE; GLYCOLIC ACIDS; MICROBICIDES; MUCIN; PLGA NANOPARTICLES; POLY(D,L-LACTIC-CO-GLYCOLIC ACID); RESPONSE-SURFACE METHODOLOGY; VAGINAL DRUG DELIVERY;

NANOPARTICLES;

DAPIVIRINE; MICROBICIDE; MUCIN; POLYGLACTIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIINFECTIVE AGENT; CHEMOKINE; NANOPARTICLE; PYRIMIDINE DERIVATIVE; TMC120-R147681;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DELAYED DRUG RELEASE; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RETENTION; DRUG SAFETY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MEMBRANE PERMEABILITY; MOUSE; NANOEMULSION; NANOENGINEERING; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CELL DEATH; CELL LINE RAW 264.7; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; ENDOCYTOSIS; FEMALE; HELA CELL LINE; HYDRODYNAMICS; INFLAMMATION; METABOLISM; NANOTECHNOLOGY; PARTICLE SIZE; PATHOLOGY; PROCEDURES; TEMPERATURE; VAGINA;

ANIMALS; ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CHEMOKINES; DRUG LIBERATION; ENDOCYTOSIS; FEMALE; HELA CELLS; HUMANS; HYDRODYNAMICS; INFLAMMATION; MICE; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PYRIMIDINES; RAW 264.7 CELLS; TEMPERATURE; VAGINA;

EID: 84927032988     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.02.007     Document Type: Article

References (68)

1. A.T. Haase Targeting early infection to prevent HIV-1 mucosal transmission Nature 464 2010 217 223
2. Q. Abdool Karim, S.S. Abdool Karim, J.A. Frohlich, A.C. Grobler, C. Baxter, and L.E. Mansoor Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women Science 329 2010 1168 1174
3. O.J. D'Cruz, and F.M. Uckun Vaginal microbicides and their delivery platforms Expert Opin Drug Delivery 11 2014 723 740
4. R.K. Malcolm, S.M. Fetherston, C.F. McCoy, P. Boyd, and I. Major Vaginal rings for delivery of HIV microbicides Int J Womens Health 4 2012 595 605
5. C. Purslow Researchers announce launch of latest HIV microbicide trial Expert Rev Clin Pharmacol 5 2012 497
6. J. das Neves, M.M. Amiji, M.F. Bahia, and B. Sarmento Nanotechnology-based systems for the treatment and prevention of HIV/AIDS Adv Drug Delivery Rev 62 2010 458 477
7. J. das Neves, R. Nunes, A. Machado, and B. Sarmento Polymer-based nanocarriers for vaginal drug delivery Adv Drug Delivery Rev 2014 10.1016/j.addr.2014.12.004
8. J. das Neves, C.M. Rocha, M.P. Gonçalves, R.L. Carrier, M. Amiji, and M.F. Bahia Interactions of microbicide nanoparticles with a simulated vaginal fluid Mol Pharm 9 2012 3347 3356
9. T. Zhang, T.F. Sturgis, and B.B. Youan pH-responsive nanoparticles releasing tenofovir intended for the prevention of HIV transmission Eur J Pharm Biopharm 79 2011 526 536
10. S. Yang, Y. Chen, K. Gu, A. Dash, C.L. Sayre, and N.M. Davies Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4(+) immune cells Int J Nanomed 8 2013 2847 2858
11. J. das Neves, F. Araújo, F. Andrade, J. Michiels, K.K. Ariën, and G. Vanham In vitro and ex vivo evaluation of polymeric nanoparticles for vaginal and rectal delivery of the anti-HIV drug dapivirine Mol Pharm 10 2013 2793 2807
12. J. das Neves, J. Michiels, K.K. Ariën, G. Vanham, M. Amiji, and M.F. Bahia Polymeric nanoparticles affect the intracellular delivery, antiretroviral activity and cytotoxicity of the microbicide drug candidate dapivirine Pharm Res 29 2012 1468 1484
13. T. Chaowanachan, E. Krogstad, C. Ball, and K.A. Woodrow Drug synergy of tenofovir and nanoparticle-based antiretrovirals for HIV prophylaxis PLoS One 8 2013 e61416
14. J. das Neves, F. Araújo, F. Andrade, M. Amiji, M.F. Bahia, and B. Sarmento Biodistribution and pharmacokinetics of dapivirine-loaded nanoparticles after vaginal delivery in mice Pharm Res 31 2014 1834 1845
15. R. Mallipeddi, and L.C. Rohan Nanoparticle-based vaginal drug delivery systems for HIV prevention Expert Opin Drug Delivery 7 2010 37 48
16. J. das Neves, M. Amiji, and B. Sarmento Mucoadhesive nanosystems for vaginal microbicide development: friend or foe? Wiley Interdiscip Rev Nanomed Nanobiotechnol 3 2011 389 399
17. M. Abul Kalam, Y. Sultana, A. Ali, M. Aqil, A.K. Mishra, and I.A. Aljuffali Part I: Development and optimization of solid-lipid nanoparticles using Box-Behnken statistical design for ocular delivery of gatifloxacin J Biomed Mater Res A 101 2013 1813 1827
18. F. Yerlikaya, A. Ozgen, I. Vural, O. Guven, E. Karaagaoglu, and M.A. Khan Development and evaluation of paclitaxel nanoparticles using a quality-by-design approach J Pharm Sci 102 2013 3748 3761
19. D. Alukda, T. Sturgis, and B.B. Youan Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention J Pharm Sci 100 2011 3345 3356
20. J. das Neves, B. Sarmento, M.M. Amiji, and M.F. Bahia Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles J Pharm Biomed Anal 52 2010 167 172
21. D.H. Owen, and D.F. Katz A vaginal fluid simulant Contraception 59 1999 91 95
22. J.W. Moore, and H.H. Flanner Mathematical comparison of dissolution profiles Pharm Tech 20 1996 64 74
23. J. das Neves, M. Amiji, M.F. Bahia, and B. Sarmento Assessing the physical-chemical properties and stability of dapivirine-loaded polymeric nanoparticles Int J Pharm 456 2013 307 314
24. K.K. Ariën, G. Vanham, and Y. Gali A dual-chamber model of the female genital tract to evaluate epithelial toxicity of candidate anti-HIV microbicides Curr Protoc Cell Biol 2011 Chapter 26:Unit26.13
25. C. Grammen, P. Augustijns, and J. Brouwers In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients Antiviral Res 96 2012 226 233
26. J. das Neves, B. Sarmento, M. Amiji, and M.F. Bahia Development and validation of a HPLC method for the assay of dapivirine in cell-based and tissue permeability experiments J Chromatogr B Analyt Technol Biomed Life Sci 911 2012 76 83
27. F. Danhier, E. Ansorena, J.M. Silva, R. Coco, A. Le Breton, and V. Preat PLGA-based nanoparticles: an overview of biomedical applications J Controlled Release 161 2012 505 522
28. J.M. Steinbach, C.E. Weller, C.J. Booth, and W.M. Saltzman Polymer nanoparticles encapsulating siRNA for treatment of HSV-2 genital infection J Controlled Release 162 2012 102 110
29. M. Yang, T. Yu, Y.Y. Wang, S.K. Lai, Q. Zeng, and B. Miao Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth Adv Healthc Mater 3 2013 1044 1052
30. Z.G. Tang, J.T. Callaghan, and J.A. Hunt The physical properties and response of osteoblasts to solution cast films of PLGA doped polycaprolactone Biomaterials 26 2005 6618 6624
31. Z.G. Tang, N.P. Rhodes, and J.A. Hunt Control of the domain microstructures of PLGA and PCL binary systems: importance of morphology in controlled drug release Chem Eng Res Des 85 2007 1044 1050
32. Y. Van Herrewege, J. Michiels, J. Van Roey, K. Fransen, L. Kestens, and J. Balzarini In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides Antimicrob Agents Chemother 48 2004 337 339
33. B. Singh, R. Kumar, and N. Ahuja Optimizing drug delivery systems using systematic "design of experiments". Part I: Fundamental aspects Crit Rev Ther Drug Carrier Syst 22 2005 27 105
34. S.K. Sahoo, J. Panyam, S. Prabha, and V. Labhasetwar Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake J Controlled Release 82 2002 105 114
35. S.-J. Lee, J.-R. Jeong, S.-C. Shin, J.-C. Kim, Y.-H. Chang, and K.-H. Lee Magnetic enhancement of iron oxide nanoparticles encapsulated with poly (d,l-latide-co-glycolide) Colloids Surf A Physicochem Eng Asp 255 2005 19 25
36. R.M. Mainardes, and R.C. Evangelista PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution Int J Pharm 290 2005 137 144
37. T.W. Chung, Y.Y. Huang, and Y.Z. Liu Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres Int J Pharm 212 2001 161 169
38. U. Bilati, E. Allemann, and E. Doelker Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method Pharm Dev Technol 8 2003 1 9
39. P.D. Scholes, A.G.A. Coombes, L. Illum, S.S. Daviz, M. Vert, and M.C. Davies The preparation of sub-200 nm poly (lactide-co-glycolide) microspheres for site-specific drug delivery J Controlled Release 25 1993 145 153
40. J. Rejman, V. Oberle, I.S. Zuhorn, and D. Hoekstra Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis Biochem J 377 2004 159 169
41. K.Y. Win, and S.S. Feng Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs Biomaterials 26 2005 2713 2722
42. S.K. Lai, D.E. O'Hanlon, S. Harrold, S.T. Man, Y.Y. Wang, and R. Cone Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Proc Natl Acad Sci USA 104 2007 1482 1487
43. A.M. Torche, P. Le Corre, E. Albina, A. Jestin, and R. Le Verge PLGA microspheres phagocytosis by pig alveolar macrophages: influence of poly(vinyl alcohol) concentration, nature of loaded-protein and copolymer nature J Drug Target 7 2000 343 354
44. A. Budhian, S.J. Siegel, and K.I. Winey Controlling the in vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles Int J Pharm 346 2008 151 159
45. B.S. Zolnik, and D.J. Burgess Effect of acidic pH on PLGA microsphere degradation and release J Controlled Release 122 2007 338 344
46. Z.H. Ping, Q.T. Nguyen, S.M. Chen, J.Q. Zhou, and Y.D. Ding States of water in different hydrophilic polymers-DSC and FTIR studies Polymer 42 2001 8461 8467
47. Z.H. Mbhele, M.G. Salemane, C.G.C.E. van Sittert, J.M. Nedeljkovic, V. Djokovic, and A.S. Luyt Fabrication and characterization of silver-polyvinyl alcohol nanocomposites Chem Mater 15 2003 5019 5024
48. M. Dunne, I. Corrigan, and Z. Ramtoola Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles Biomaterials 21 2000 1659 1668
49. K.M. Gupta, S.M. Pearce, A.E. Poursaid, H.A. Aliyar, P.A. Tresco, and M.A. Mitchnik Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1 J Pharm Sci 97 2008 4228 4239
50. I. Major, P. Boyd, M. Kilbourne-Brook, G. Saxon, J. Cohen, and R.K. Malcolm A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine Contraception 88 2012 58 66
51. D.J. Murphy, D. Desjardins, N. Dereuddre-Bosquet, P. Brochard, L. Perrot, and A. Pruvost Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir J Antimicrob Chemother 69 2014 2477 2488
52. X. Chen, C.P. Ooi, and T.H. Lim Effect of ganciclovir on the hydrolytic degradation of poly(lactide-co-glycolide) microspheres J Biomater Appl 20 2006 287 302
53. K.K. Ariën, V. Jespers, and G. Vanham HIV sexual transmission and microbicides Rev Med Virol 21 2011 110 133
54. M.A. Moretton, D.A. Chiappetta, F. Andrade, J. das Neves, D. Ferreira, and B. Sarmento Hydrolyzed galactomannan-modified nanoparticles and flower-like polymeric micelles for the active targeting of rifampicin to macrophages J Biomed Nanotechnol 9 2012 1076 1087
55. P. Lewi, J. Heeres, K. Ariën, M. Venkatraj, J. Joossens, and P. Van der Veken Reverse transcriptase inhibitors as microbicides Curr HIV Res 10 2012 27 35
56. Y. Gali, O. Delezay, J. Brouwers, N. Addad, P. Augustijns, and T. Bourlet In vitro evaluation of viability, integrity and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides Antimicrob Agents Chemother 54 2010 5105 5114
57. C.S. Dezzutti, E.R. Brown, B. Moncla, J. Russo, M. Cost, and L. Wang Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity PLoS One 7 2012 e48328
58. A.M. Nel, P. Coplan, J.H. van de Wijgert, S.H. Kapiga, C. von Mollendorf, and E. Geubbels Safety, tolerability, and systemic absorption of dapivirine vaginal microbicide gel in healthy, HIV-negative women AIDS 23 2009 1531 1538
59. B. Devlin, J. Nuttall, S. Wilder, C. Woodsong, and Z. Rosenberg Development of dapivirine vaginal ring for HIV prevention Antiviral Res 100 Suppl. 2013 S3 S8
60. R.N. Fichorova, L.D. Tucker, and D.J. Anderson The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission J Infect Dis 184 2001 418 428
61. R.N. Fichorova, M. Bajpai, N. Chandra, J.G. Hsiu, M. Spangler, and V. Ratnam Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives Biol Reprod 71 2004 761 769
62. D.T. Merrick, G. Winberg, and J.K. McDougall Re-expression of interleukin 1 in human papillomavirus 18 immortalized keratinocytes inhibits their tumorigenicity in nude mice Cell Growth Differ 7 1996 1661 1669
63. B. Sarmento, F. Andrade, S.B. da Silva, F. Rodrigues, J. das Neves, and D. Ferreira Cell-based in vitro models for predicting drug permeability Expert Opin Drug Metab Toxicol 8 2012 607 621
64. J. das Neves, R. Palmeira-de-Oliveira, A. Palmeira-de-Oliveira, F. Rodrigues, and B. Sarmento Vaginal mucosa and drug delivery V.V. Khutoryanskiy, Mucoadhesive Materials and Drug Delivery Systems 2014 Wiley Chichester, UK 99 131
65. J. Romano, A. Kashuba, S. Becker, J. Cummins, and J. Turpin Pharmacokinetics and pharmacodynamics in HIV prevention; Current status and future directions: a summary of the DAIDS and BMGF sponsored think tank on pharmacokinetics (PK)/pharmacodynamics (PD) in HIV prevention AIDS Res Hum Retroviruses 29 2013 1418 1427
66. Chen BA. Safety and pharmacokinetics/pharmacodynamics of dapivirine and maraviroc vaginal rings. CROI 2014-Conference on Retroviruses and Opportunistic Infections. Boston, MA, USA; 2014.
67. A. Sosnik, J. das Neves, and B. Sarmento Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review Prog Polym Sci 39 2014 2030 2075
68. R.A. Cone Barrier properties of mucus Adv Drug Delivery Rev 61 2009 75 85