Development and validation of a HPLC method for the assay of dapivirine in cell-based and tissue permeability experiments

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 911, Issue , 2012, Pages 76-83

  das Neves, José ^a,b   Sarmento, Bruno ^a,b,c   Amiji, Mansoor ^d   Bahia, Maria Fernanda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^d NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Box Behnken design; Diphenylamine; Liquid chromatography; Method validation; Microbicides; Polymeric nanoparticles

Indexed keywords

BOX-BEHNKEN DESIGN; DIPHENYLAMINE; METHOD VALIDATIONS; MICROBICIDES; POLYMERIC NANOPARTICLES;

ACETONITRILE; ANILINE; ASSAYS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; LIQUID CHROMATOGRAPHY; MONOLAYERS; NANOPARTICLES; TISSUE;

EXPERIMENTS;

ACETONITRILE; DAPIVIRINE; DIPHENYLAMINE; NANOPARTICLE; TRIFLUOROACETIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BOX BEHNKEN EXPERIMENTAL DESIGN; CELL ASSAY; CELL LYSATE; CONTROLLED STUDY; DRUG UPTAKE; EX VIVO STUDY; EXPERIMENTAL DESIGN; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MUCOSA; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SWINE; TISSUE HOMOGENATE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

ADULT; ANIMALS; CACO-2 CELLS; CELL LINE; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG STABILITY; HELA CELLS; HUMANS; INTRACELLULAR SPACE; LINEAR MODELS; MICE; MUCOUS MEMBRANE; NANOPARTICLES; POLYESTERS; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SWINE;

SUIDAE;

EID: 84869881524     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.10.034     Document Type: Article

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