Biodistribution and pharmacokinetics of Dapivirine-loaded nanoparticles after vaginal delivery in mice

Pharmaceutical Research

Volumn 31, Issue 7, 2014, Pages 1834-1845

  Das Neves, José ^a,b   Araújo, Francisca ^a,c   Andrade, Fernanda ^b   Amiji, Mansoor ^d   Bahia, Maria Fernanda ^b   Sarmento, Bruno ^a,c  

^a UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^d NORTHEASTERN UNIVERSITY   (United States)

Author keywords

HIV AIDS; microbicides; poly( caprolactone); pre exposure prophylaxis; vaginal drug delivery

Indexed keywords

DAPIVIRINE; MACROGOL; NANOCARRIER; NANOPARTICLE; POLYCAPROLACTONE; POLYESTER; POLYETHYLENE OXIDE-POLYCAPROLACTONE COPOLYMER; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; TMC120-R147681;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG PENETRATION; DRUG SAFETY; EPITHELIUM; FEMALE; GENITAL SYSTEM; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SUSPENSION; UTERUS; VAGINA; VAGINAL LAVAGE; ANIMAL; HIV INFECTIONS; INTRAVAGINAL DRUG ADMINISTRATION; METABOLISM; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; FEMALE; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; MICE; NANOPARTICLES; POLYESTERS; PYRIMIDINES; TISSUE DISTRIBUTION; VAGINA;

EID: 84904252215     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1287-x     Document Type: Article

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