High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 331-336

  Bian, Ou ^a   Zhang, Haishan ^a   Guan, Qigang ^a   Sun, Yingxian ^a   Zeng, Dingyin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Connexin 43; Gap junction intercellular communication; Insulin; Vascular smooth muscle cell

Indexed keywords

CATALASE; CONNEXIN 43; HYDROGEN PEROXIDE; INSULIN; ANTIDIABETIC AGENT; GLUCOSE;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GAP JUNCTION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN RELEASE; INSULIN TREATMENT; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL COMMUNICATION; CELLS, CULTURED; CONNEXIN 43; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GAP JUNCTIONS; GLUCOSE; HYDROGEN PEROXIDE; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; INSULIN; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84926671097     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3437     Document Type: Article

References (47)

1. Chadjichristos CE, Morel S, Derouette JP, et al: Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells. Circ Res 102: 653-660, 2008.
2. Inoguchi T, Yu HY, Imamura M, et al: Altered gap junction activity in cardiovascular tissues of diabetes. Med Electron Microsc 34: 86-91, 2001.
3. Figueroa XF, Isakson BE and Duling BR: Connexins: gaps in our knowledge of vascular function. Physiology (Bethesda) 19: 277-284, 2004.
4. Coutinho P, Qiu C, Frank S, Tamber K and Becker D: Dynamic changes in connexin expression correlate with key events in the wound healing process. Cell Biol Int 27: 525-541, 2003.
5. Liao Y, Regan CP, Manabe I, et al: Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury. Arterioscler Thromb Vasc Biol 27: 1037-1042, 2007.
6. Johnstone S, Isakson B and Locke D: Biological and biophysical properties of vascular connexin channels. Int Rev Cell Mol Biol 278: 69-118, 2009.
7. Evans WH and Martin PE: Gap junctions: structure and function (Review). Mol Membr Biol 19: 121-136, 2002.
8. Haefliger JA, Nicod P and Meda P: Contribution of connexins to the function of the vascular wall. Cardiovasc Res 62: 345-356, 2004.
9. Joshi CN, Martin DN, Shaver P, Madamanchi C, Muller-Borer BJ and Tulis DA: Control of vascular smooth muscle cell growth by connexin 43. Front Physiol 3: 220, 2012.
10. Johnstone SR, Kroncke BM, Straub AC, et al: MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circ Res 111: 201-211, 2012.
11. Jia G, Cheng G, Gangahar DM and Agrawal DK: Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway. J Mol Cell Cardiol 44: 882-890, 2008.
12. Earley S, Resta TC and Walker BR: Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries. Am J Physiol Heart Circ Physiol 287: H2677-H2686, 2004.
13. Rocha ML, Kihara AH, Davel AP, Britto LR, Rossoni LV and Bendhack LM: Blood pressure variability increases connexin expression in the vascular smooth muscle of rats. Cardiovasc Res 80: 123-130, 2008.
14. Slovut DP, Mehta SH, Dorrance AM, Brosius FC, Watts SW and Webb RC: Increased vascular sensitivity and connexin43 expression after sympathetic denervation. Cardiovasc Res 62: 388-396, 2004.
15. Hong T, Wang H and Wang Y: Effects of gap junctional blockers on cerebral vasospasm after subarachnoid hemorrhage in rabbits. Neurol Res 31: 238-244, 2009.
16. Wang H, Hong T, Wang H and Wang Y: Altered expression of connexin43 and its possible role in endothelin-1-induced contraction in rabbit basilar artery. Neurol Res 31: 67-73, 2009.
17. Wei JM, Wang X, Gong H, Shi YJ and Zou Y: Ginkgo suppresses atherosclerosis through downregulating the expression of connexin 43 in rabbits. Arch Med Sci 9: 340-346, 2013.
18. Kwak BR, Mulhaupt F, Veillard N, Gros DB and Mach F: Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol 22: 225-230, 2002.
19. Kwak BR, Veillard N, Pelli G, et al: Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation 107: 1033-1039, 2003.
20. Breen DM and Giacca A: Effects of insulin on the vasculature. Curr Vasc Pharmacol 9: 321-332, 2011.
21. Anfossi G, Russo I, Doronzo G and Trovati M: Contribution of insulin resistance to vascular dysfunction. Arch Physiol Biochem 115: 199-217, 2009.
22. Muniyappa R, Montagnani M, Koh KK and Quon MJ: Cardiovascular actions of insulin. Endocr Rev 28: 463-491, 2007.
23. Muniyappa R and Quon MJ: Insulin action and insulin resistance in vascular endothelium. Curr Opin Clin Nutr Metab Care 10: 523-530, 2007.
24. Lo HM, Hung CF, Tseng YL, Chen BH, Jian JS and Wu WB: Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Biochem Pharmacol 74: 54-63, 2007.
25. Pyla R, Poulose N, Jun JY and Segar L: Expression of conventional and novel glucose transporters, GLUT1, -9, -10 and -12, in vascular smooth muscle cells. Am J Physiol Cell Physiol 304: C574-C589, 2013.
26. Shen J, Wang LH, Zheng LR, Zhu JH and Hu SJ: Lovastatin inhibits gap junctional communication in cultured aortic smooth muscle cells. J Cardiovasc Pharmacol Ther 15: 296-302, 2010.
27. Tao R, Hu MF, Lou JT and Lei YL: Effects of H pylori infection on gap-junctional intercellular communication and proliferation of gastric epithelial cells in vitro. World J Gastroenterol 13: 5497-5500, 2007.
28. Zhang Y, Wang Y, Wang X, et al: Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated downregulation of p21. J Hypertens 29: 1560-1568, 2011.
29. Wang CC, Gurevich I and Draznin B: Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes 52: 2562-2569, 2003.
30. Salt IP: Examining the role of insulin in the regulation of cardiovascular health. Future Cardiol 9: 39-52, 2013.
31. Reaven GM: The insulin resistance syndrome: Definition and dietary approaches to treatment. Annu Rev Nutr 25: 391-406, 2005.
32. Zhang WY, Lee JJ, Kim Y, et al: Effect of eriodictyol on glucose uptake and insulin resistance in vitro. J Agric Food Chem 60: 7652-7658, 2012.
33. Niu P, Zhang Y, Shi D, Chen Y and Deng J: Cardamonin ameliorates insulin resistance induced by high insulin and high glucose through the mTOR and signal pathway. Planta Med 79: 452-458, 2013.
34. Liu G, Hitomi H, Hosomi N, et al: Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor. Exp Cell Res 317: 2420-2428, 2011.
35. Figueroa XF and Duling BR: Gap junctions in the control of vascular function. Antioxid Redox Signal 11: 251-266, 2009.
36. Lim MC, Maubach G and Zhuo L: TGF-beta1 down-regulates connexin 43 expression and gap junction intercellular communication in rat hepatic stellate cells. Eur J Cell Biol 88: 719-730, 2009.
37. Richards TS, Dunn CA, Carter WG, Usui ML, Olerud JE and Lampe PD: Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368. J Cell Biol 167: 555-562, 2004.
38. Weyer C, Funahashi T, Tanaka S, et al: Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86: 1930-1935, 2001.
39. Fujiwara T, Saitoh S, Takagi S, et al: Development and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia. Hypertens Res 28: 665-670, 2005.
40. DeFronzo RA and Ferrannini E: Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194, 1991.
41. Lewis GF, Uffelman KD, Szeto LW and Steiner G: Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes 42: 833-842, 1993.
42. Henriksen EJ, Diamond-Stanic MK and Marchionne EM: Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med 51: 993-999, 2011.
43. Tiganis T: Reactive oxygen species and insulin resistance: the good, the bad and the ugly. Trends Pharmacol Sci 32: 82-89, 2011.
44. Cowan DB, Jones M, Garcia LM, et al: Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler Thromb Vasc Biol 23: 1754-1760, 2003.
45. Yang M, Yang Y, Zhang S and Kahn AM: Insulin-stimulated hydrogen peroxide increases guanylate cyclase activity in vascular smooth muscle. Hypertension 42: 569-573, 2003.
46. 2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases. J Agric Food Chem 53: 8205-8210, 2005.
47. Lee KW, Hur HJ, Lee HJ and Lee CY: Antiproliferative effects of dietary phenolic substances and hydrogen peroxide. J Agric Food Chem 53: 1990-1995, 2005.