Lovastatin inhibits gap junctional communication in cultured aortic smooth muscle cells

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 15, Issue 3, 2010, Pages 296-302

  Shen, Jing ^a   Wang, Li Hong ^a,b   Zheng, Liang Rong ^a   Zhu, Jian Hua ^a   Hu, Shen Jiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b NONE   (China)

Author keywords

aortic smooth muscle cells; fluorescence recovery after photobleaching; gap junctional intercellular communication; migration; statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CELL COMMUNICATION; CELL GROWTH; CELL JUNCTION; CELL MIGRATION; CONCENTRATION (PARAMETERS); CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GAP JUNCTION; LASER MICROSCOPY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; CELL COMMUNICATION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CONNEXIN 43; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GAP JUNCTIONS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MALE; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77956822069     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248410373750     Document Type: Article

References (34)

1. Dubey RK, Jackson EK, Luscher TF Nitric-oxide inhibits angiotensin-II-induced migration of rat aortic smooth muscle cell-role of cyclic-nucleotides and angiotensin1 receptors. J Clin Invest. 1995 ; 96 (1). 141-149.
2. Wang LH, Chen JZ, Sun YL, et al. Statins reduce connexin40 and connexin43 expression in atherosclerotic aorta of rabbits. Int J Cardiol. 2005 ; 100 (3). 467-475.
3. Jia G., Cheng G., Agrawal DK Autophagy of vascular smooth muscle cells in atherosclerotic lesions. Autophagy. 2007 ; 3 (1). 63-64.
4. Kwak BR, Mulhaupt F., Veillard N., Gros DB, Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2002 ; 22 (2). 225-230.
5. Wang LH, Chen JZ, Sun YL, et al. Regulation of connexin expression after balloon injury: possible mechanisms for antiproliferative effect of statins. Am J Hypertens. 2005 ; 18 (9 pt 1). 1146-1153.
6. Evans WH, Martin PE Gap junctions: structure and function (review). Mol Membr Biol. 2002 ; 19 (2). 121-136.
7. Figueroa XF, Isakson BE, Duling BR Connexins: gaps in our knowledge of vascular function. Physiology. 2004 ; 19 (5). 277-284.
8. Hill CE, Rummery N., Hickey H., Sandow SL Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Clin Exp Pharmacol Physiol. 2002 ; 29 (7). 620-625.
9. Li X., Simard JM Increase in Cx45 gap junction channels in cerebral smooth muscle cells from SHR. Hypertension. 2002 ; 40 (6). 940-946.
10. Beauchamp P., Yamada KA, Baertschi AJ, et al. Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ Res. 2006 ; 99 (11). 1216-1224.
11. Peters NS Gap junctions: clarifying the complexities of connexins and conduction (review). Circ Res. 2006 ; 99 (11). 1156-1158.
12. Kanagaratnam P., Rothery S., Patel P., Severs NJ, Peters NS Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction properties. J Am Coll Cardiol. 2002 ; 39 (1). 116-123.
13. Kanagaratnam P., Cherian A., Stanbridge RDL, Glenville B., Severs NJ, Peters NS Relationship between connexins and atrial activation during human atrial fibrillation. J Cardiovasc Electrophysiol. 2004 ; 15 (2). 206-213.
14. Kojodjojo P., Kanagaratnam P., Segal OR, Hussain W., Peters NS The effects of carbenoxolone on human myocardial conduction: a tool to investigate the role of gap junctional uncoupling in human arrhythmogenesis. J Am Coll Cardiol. 2006 ; 48 (6). 1242-1249.
15. Kwak BR, Veillard N., Pelli G., et al. Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation. 2003 ; 107 (7). 1033-1039.
16. Lo HM, Hung CF, Tseng YL, Chen BH, Jian JS, Wu WB Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Biochem Pharmacol. 2007 ; 74 (1). 54-63.
17. Odonnell MP, Kasiske BL, Kim Y., Atluru D., Keane WF Lovastatin inhibits proliferation of rat mesangial cells. J Clin Invest. 1993 ; 91 (1). 83-87.
18. Morimoto K., Janssen WJ, Fessler MB, et al. Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol. 2006 ; 176 (12). 7657-7665.
19. Corpataux JM, Naik J., Porter KE, London NJM. The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells. J Surg Res. 2005 ; 129 (1). 52-56.
20. Redmond EM, Cullen JP, Cahill PA, et al. Endothelial cells inhibit flow-Induced smooth muscle cell migration: role of plasminogen activator inhibitor-1. Circulation. 2001 ; 103 (4). 597-603.
21. Gomes P., Srinivas SP, Vereecke J., Himpens B. Gap junctional intercellular communication in bovine corneal endothelial cell. Exp Eye Res. 2006 ; 83 (5). 1225-1237.
22. Goodwin JS, Kenworthy AK Photobleaching approaches to investigate diffusional mobility and trafficking of Ras in living cells. Methods. 2005 ; 37 (2). 154-164.
23. Zeng QL, Ke XQ, Gao XW, et al. Noise magnetic fields abolish the gap junction intercellular communication suppression induced by 50 Hz magnetic fields. Bioelectromagnetics. 2006 ; 27 (4). 274-279.
24. Wentlandt K., Samoilova M., Carlen PL, El Beheiry H. General anesthetics inhibit gap junction communication in cultured organotypic hippocampal slices. Anesth Analg. 2006 ; 102 (6). 1692-1698.
25. Bellosta S., Via D., Canavesi M., et al. HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages. Arterioscler Thromb Vasc Biol. 1998 ; 18 (11). 1671-1678.
26. Corsini A., Pazzucconi F., Arnaboldi L., et al. Direct effects of statins on the vascular wall. J Cardiovasc Pharmacol. 1998 ; 31 (5). 773-778. (Pubitemid 28217599)
27. Fukumoto Y., Libby P., Rabkin E., et al. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Watanabe heritable hyperlipidemic rabbits. Circulation. 2001 ; 103 (7). 993-999.
28. Porter KE, Naik J., Turner NA, Dickinson T., Thompson MM, London NJM. Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. J Vasc Surg. 2002 ; 36 (1). 150-157.
29. Van Zeijl L., Ponsioen B., Giepmans BNG, et al. Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol. 2007 ; 177 (5). 881-891.
30. Abbaci M., Barberi-Heyob M., Blondel W., Guillemin F., Didelon J. Advantages and limitations of commonly used methods to assay the molecular permeability of gap junctional intercellular communication. Biotechniques. 2008 ; 45 (1). 33-62.
31. Campbell M., Allen WE, Sawyer C., Vanhaesebroeck B., Trimble ER Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways. Circ Res. 2004 ; 95 (4). 380-388.
32. Bell RM, Yellon DM Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway. J Am Coll Cardiol. 2003 ; 41 (3). 508-515.
33. Chen Z., Fukutomi T., Zago AC, et al. Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipids. Circulation. 2002 ; 106 (1). 20-23.
34. Weiss RH, Ramirez A., Joo A. Short-term pravastatin mediates growth inhibition and apoptosis, independently of Ras, via the signalling proteins p27 KIP1 and PI3 Kinase. J Am Soc Nephrol. 1999 ; 10 (9). 1880-1890.