Altered expression of connexin43 and its possible role in endothelin-1-induced contraction in rabbit basilar artery

Neurological Research

Volumn 31, Issue 1, 2009, Pages 67-73

  Wang, Haitao ^a   Hong, Tao ^a   Wang, Huan ^a   Wang, Yang ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Carbenoxolone; cerebral vasospasm; Connexin43; ET 1; Gap junction

Indexed keywords

CARBENOXOLONE; CONNEXIN 43; DYE; ENDOTHELIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BASILAR ARTERY; BRAIN BLOOD VESSEL; BRAIN VASOSPASM; CELL COMMUNICATION; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GAP JUNCTION; MODULATION; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RABBIT; SMOOTH MUSCLE FIBER; SUBARACHNOID HEMORRHAGE; TENSION; WESTERN BLOTTING;

ANIMALS; ANTI-ULCER AGENTS; BASILAR ARTERY; BLOTTING, WESTERN; CARBENOXOLONE; CELL COMMUNICATION; CONNEXIN 43; ENDOTHELIN-1; GAP JUNCTIONS; GENE EXPRESSION; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RABBITS; VASOSPASM, INTRACRANIAL;

EID: 60849133032     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164108X323726     Document Type: Article

References (50)

1. Chow M, Dumont AS, Kassell NF. Endothelin receptor antagonists and cerebral vasospasm: An update. Neurosurgery 2002; 51: 1333-1341
2. Cosentino F, McMahon EG, Carter JS, et al. Effect of endothelin-A receptor antagonist BQ-123 and phosphoramidon on cerebral vasospasm. J Cardiovasc Pharmacol 1993; 22: 332-335
3. Seifert V, Loffler B, Zimmermann M, et al. Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. Correlation with cerebral vasospasm, delayed ischemic neurological deficits, and volume of hematoma. J Neurosurg 1995; 82: 55-62
4. Zimmermann M, Seifert V. Endothelin and subarachnoid hemorrhage: An overview. Neurosurgery 1998; 43: 863- 876
5. Kasuya H, Weir BK, White DM, et al. Mechanism of oxyhemoglobin-induced release of endothelin-1 from cultured vascular endothelial cells and smooth muscle cells. J Neurosurg 1993; 79: 892-898
6. Ohlstein EH, Storer BL. Oxyhemoglobin stimulation of endothelin production in cultured endothelial cells. J Neurosurg 1992; 77: 274-278
7. Shirakami G, Magaribuchi T, Shingu K, et al. Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage. Acta Anaesthesiol Scand 1994; 38: 457-461
8. Suzuki R, Masaoka H, Hirata Y, et al. The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 1992; 77: 96-100
9. Kobayashi H, Hayashi M, Kobayashi S, et al. Effect of endothelin on the canine basilar artery. Neurosurgery 1990; 27: 357-361
10. Kwan AL, Lin CL, Chang CZ, et al. Continuous intravenous infusion ofCGS 26303, an endothelinconverting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage. Neurosurgery 2001; 49: 422-429
11. Zimmermann M, Jung C, Raabe A, et al. Inhibition of endothelin- converting enzyme activity in the rabbit basilar artery. Neurosurgery 2001; 48: 902-910
12. Li X, Simard JM. Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2001; 281: H1890-H1898
13. Li X, Simard JM. Increase in Cx45 gap junction channels in cerebral smooth muscle cells from SHR. Hypertension 2002; 40: 940-946
14. Haddock RE, Grayson TH. Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins37 and 40. Am JPhysiol Heart Circ Physiol 2006; 291: H2047- H2056
15. Tyagi MG, Parthiban KV. Vasopressin mediates neuroprotection in mice by stimulation of V1 vasopressin receptors: Influence of PI-3 kinase and gap junction inhibitors. Indian J Exp Biol 2003; 41:574-580
16. Yamazaki J, Kitamura K. Intercellular electrical coupling in vascular cells present in rat intact cerebral arterioles. Vasc Res 2003; 40: 11-27
17. Hong T, Wang HT, Wang Y, et al. Effects of gap junctional blockers on cerebral vasospasm after subarachnoid hemorrhage in rabbits. Neurol Res 2008; in press
18. Brink PR, Valunias V. Homotypic, heterotypic and heteromeric gap junctions. In: Perrachia C, ed. Gap Junctions, New York: Academic Press, 2000
19. Rozental R. Gap junctions in the cardiovascular and immune systems. Braz J Med Biol Res 2000; 33: 365-368
20. Christ GJ, Brink PR. Gap junctions in isolated rat aorta: Evidence for contractile responses that exhibit a differential dependence on intercellular communication. Braz J Med Biol Res Res 2000; 33:423-429
21. Polontchouk L, Ebelt B, Jackels M, et al. Chronic effects of endothelin-1 and angiotensin-II on gap junctions and intercellular communication in cardiac cells. FASEB J 2002; 16: 87-89
22. Vollrath B, Chan P, Findlay M, et al. Lazaroids and deferoxamine attenuate the intracellular effects of oxyhemoglobin in vascular smooth muscle. Cardiovasc Res 1995; 30: 619-626
23. Vollrath B, Cook D, Megyesi J, et al. Novel mechanism by which hemoglobin induces constriction of cerebral arteries. Eur J Pharmacol 1998; 361: 311-319
24. Wickman G, Lan C, Vollrath B. Functional roles of the Rho/Rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin. Relevance to subarachnoid hemorrhage and vasospasm. Circ Res 2003; 92: 809-816
25. Le AC, Musil LS. Normal differentiation of cultured lens cells after inhibition of gap junction-mediated intercellular communication. Dev Biol 1998; 204: 80-96
26. Musil LS, Le AC, Vanslyke JK, et al. Regulation of connexin degradation as a mechanism to increase gap junction assembly and function. J Biol Chem 2000; 275: 25207-25215
27. McNeil PL, Murphy RF, Lanni F, et al. A method for incorporating macromolecules into adherent cells. J Cell Biol 1984; 98: 1556-1564
28. El-Fouly MH, Trosko JE, Chang CC. Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication. Exp Cell Res 1987; 168: 422-430
29. Zubkov AY, Rollins KS, Parent AD, et al. Mechanism of endothelin-1-induced contraction in rabbit basilar artery. Stroke 2000; 31: 526-533
30. Sagar GD, Larson DM. Carbenoxolone inhibits junctional transfer and upregulates Connexin43 expression by a protein kinase A- dependent pathway. J Cell Biochem 2006; 98: 1543-1551
31. Billerr J, Godersky JC, Adams HPJ. Management of aneurismal subarachnoid hemorrhage. Stroke 1988; 19: 1300-1305
32. Lagaud G, Karicheti V. Blockers of gap junctions attenuate myogenic tone in cerebral arteries. Am J Physiol 2002; 283:H2177-H2186
33. Rozental R. Gap junctions in the cardiovascular and immune systems. Braz J Med Biol Res 2000; 33: 365-368
34. Gibbins IL, Morris JL, Furness JB, et al. Nonadrenergic Innervation of Blood Vessels, Boca Raton, FL: CRC Press, 1987: pp. 1-36
35. Hirst GD, Edwards FR. Sympathetic neuroeffector transmission in arteries and arterioles. Physiol Rev 1989; 69: 546-604
36. Christ GJ, Spray DC, El-Sabban M, et al. Gap junctions in vascular tissues. Evaluating the role of intercellular communication in the modulation of vasomotor tone. Circ Res 1996; 79: 631-646
37. Christ GJ, Brink PR. An analysis of the presence and physiological relevance of subconducting states of connexin43-derived gap junction channels in cultured human corporal vascular smooth muscle cells. Circ Res 1999; 84: 797-803
38. Chaytor AT, Evans WH, Griffith TM. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol 1997; 503: 99-110
39. Christ GJ. Modulation of a1-adrenergic contractility in isolated vascular tissues by heptanol: A functional demonstration of the potential importance of intercellular communication to vascular response generation. Life Sci 1995; 56: 709-721
40. Christ GJ, Brink PR, Zhao W, et al. Gap junctions modulate tissue contractility and a1-adrenergic agonist efficacy in isolated rat aorta. J Pharmacol Exp Ther 1993; 266: 1054-1065
41. Christ GJ, Moreno AP, Parker ME, et al. Intercellular communication through gap junctions: A potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum. Life Sci 1991; 49: L195- L200
42. Watts SW, Webb RC. Vascular gap junctional communication is increased in mineralocorticoid-salt hypertension. Hypertension 1996; 28: 888-893
43. Christ GJ, Spektor M, Brink PR, et al. Further evidence for the selective disruption of intercellular communication by heptanol. Am J Physiol 1999; 276: H1911-H1917
44. Zhang YN, Kakinuma Y. Acetylcholine Inhibits the hypoxia- induced reduction of connexin43 protein in rat cardiomyocytes. J Pharmacol Sci 2006; 101: 214-222
45. Haefliger JA, Meda P. Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells. Braz J Med Biol Res 2000; 33: 431-438
46. Fujimori A, Yanagisawa M, Saito A, et al. Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage. Lancet 1990; 336: 633
47. Gaetani P, Rodriguez y Baena R, Grignani G, et al. Endothelin and aneurysmal subarachnoid haemorrhage: A study of subarachnoid cisternal cerebrospinal fluid. J Neurol Neurosurg Psychiatry 1994; 57: 66-72
48. Suzuki H, Sato S, Suzuki Y, et al. Endothelin immunoreactivity in cerebrospinal fluid of patients with subarachnoid haemorrhage. Ann Med 1990; 22: 233-236
49. Suzuki H, Sato S, Suzuki Y, et al. Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage. Acta Neurol Scand 1990; 81: 553-554
50. Goto K, Fujii K. Critical role of gap junctions in endothelium- dependent hyperpolarization in rat mesenteric arteries. Clin Exp Pharmacol Phyrsiol 2002; 29: 95-602