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Volumn 10, Issue 3, 2015, Pages

Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro

Author keywords

[No Author keywords available]

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CADHERIN; CLAUDIN 5; LEUKOCYTE ANTIGEN; LEUPEPTIN; MESSENGER RNA; NQO1 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN ZO1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SEVEN IN ABSENTIA PROTEINS; UBIQUITIN PROTEIN LIGASE; VASCULAR ENDOTHELIAL CADHERIN;

EID: 84926665031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122358     Document Type: Article
Times cited : (60)

References (51)
  • 1
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • PMID: 21030723
    • Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010; 107: 1058-1070. doi: 10.1161/CIRCRESAHA.110.223545 PMID: 21030723
    • (2010) Circ Res , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 2
    • 0037237882 scopus 로고    scopus 로고
    • Effect of diabetes on the blood brain barrier
    • PMID: 12678883
    • Horani MH, Mooradian AD. Effect of diabetes on the blood brain barrier. Curr Pharm Des. 2003; 9: 833-840. PMID: 12678883
    • (2003) Curr Pharm Des , vol.9 , pp. 833-840
    • Horani, M.H.1    Mooradian, A.D.2
  • 3
    • 49449109529 scopus 로고    scopus 로고
    • Vascular disease and diabetes: Is hypoglycaemia an aggravating factor?
    • PMID: 18461635
    • Wright RJ, Frier BM. Vascular disease and diabetes: is hypoglycaemia an aggravating factor? Diabetes Metab Res Rev. 2008; 24: 353-363. doi: 10.1002/dmrr.865 PMID: 18461635
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 353-363
    • Wright, R.J.1    Frier, B.M.2
  • 4
    • 34147133340 scopus 로고    scopus 로고
    • Hypoglycemia, functional brain failure, and brain death
    • PMID: 17404614
    • Cryer PE. Hypoglycemia, functional brain failure, and brain death. J Clin Invest. 2007; 117: 868-870. PMID: 17404614
    • (2007) J Clin Invest , vol.117 , pp. 868-870
    • Cryer, P.E.1
  • 5
    • 4344571818 scopus 로고    scopus 로고
    • Impact of hypoglycemia and diabetes on CNS: Correlation of mitochondrial oxidative stress with DNA damage
    • PMID: 15228097
    • Singh P, Jain A, Kaur G. Impact of hypoglycemia and diabetes on CNS: correlation of mitochondrial oxidative stress with DNA damage. Mol Cell Biochem. 2004; 260: 153-159. PMID: 15228097
    • (2004) Mol Cell Biochem , vol.260 , pp. 153-159
    • Singh, P.1    Jain, A.2    Kaur, G.3
  • 6
    • 52549095864 scopus 로고    scopus 로고
    • Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death
    • PMID: 18545258
    • Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, et al. Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. J Cereb Blood Flow Metab. 2008; 28: 1697-1706. doi: 10.1038/jcbfm.2008.61 PMID: 18545258
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1697-1706
    • Suh, S.W.1    Hamby, A.M.2    Gum, E.T.3    Shin, B.S.4    Won, S.J.5    Sheline, C.T.6
  • 8
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • PMID: 15914466
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev. 2005; 57: 173-185. PMID: 15914466
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 9
    • 84926661937 scopus 로고    scopus 로고
    • In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies
    • PMID: 25098812
    • Palmiotti CA, Prasad S, Naik P, Abul KM, Sajja RK, Achyuta AH, et al. In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies. Pharm Res 31:3229-3250. doi: 10.1007/s11095-014-1464-6 PMID: 25098812
    • Pharm Res , vol.31 , pp. 3229-3250
    • Palmiotti, C.A.1    Prasad, S.2    Naik, P.3    Abul, K.M.4    Sajja, R.K.5    Achyuta, A.H.6
  • 10
    • 84898914479 scopus 로고    scopus 로고
    • Impact of altered glycaemia on blood-brain barrier endothelium: An in vitro study using the hCMEC/D3 cell line
    • PMID: 24708805
    • Sajja RK, Prasad S, Cucullo L. Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line. Fluids Barriers CNS. 2014; 11: 8. doi: 10.1186/2045-8118-11-8 PMID: 24708805
    • (2014) Fluids Barriers CNS , vol.11 , pp. 8
    • Sajja, R.K.1    Prasad, S.2    Cucullo, L.3
  • 11
    • 84879783953 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes
    • Ceriello A, Novials A, Ortega E, Canivell S, La SL, Pujadas G, et al. Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes. Diabetes Care 2013; 6: 2346-2350.
    • (2013) Diabetes Care , vol.6 , pp. 2346-2350
    • Ceriello, A.1    Novials, A.2    Ortega, E.3    Canivell, S.4    La, S.L.5    Pujadas, G.6
  • 12
    • 77958192003 scopus 로고    scopus 로고
    • Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals
    • Gogitidze JN, Hedrington MS, Briscoe VJ, Tate DB, Ertl AC, Davis SN. Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals. Diabetes Care 2010; 3: 1529-1535.
    • (2010) Diabetes Care , vol.3 , pp. 1529-1535
    • Gogitidze, J.N.1    Hedrington, M.S.2    Briscoe, V.J.3    Tate, D.B.4    Ertl, A.C.5    Davis, S.N.6
  • 13
    • 84857657883 scopus 로고    scopus 로고
    • Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: Role for AMP kinase
    • PMID: 22207730
    • Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, et al. Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. Arterioscler Thromb Vasc Biol. 2012; 32: 712-720. doi: 10.1161/ATVBAHA.111.227389 PMID: 22207730
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 712-720
    • Wang, J.1    Alexanian, A.2    Ying, R.3    Kizhakekuttu, T.J.4    Dharmashankar, K.5    Vasquez-Vivar, J.6
  • 14
    • 84878932988 scopus 로고    scopus 로고
    • Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress
    • PMID: 23776627
    • Kemeny SF, Figueroa DS, Clyne AM. Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress. PLoS One 2013; 8: e66176. doi: 10.1371/journal.pone.0066176 PMID: 23776627
    • (2013) PLoS One , vol.8 , pp. e66176
    • Kemeny, S.F.1    Figueroa, D.S.2    Clyne, A.M.3
  • 15
    • 80052256102 scopus 로고    scopus 로고
    • Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke
    • PMID: 21646410
    • Alfieri A, Srivastava S, Siow RC, Modo M, Fraser PA, Mann GE. Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke. J Physiol. 2011; 589: 4125-4136. doi: 10.1113/jphysiol.2011.210294 PMID: 21646410
    • (2011) J Physiol , vol.589 , pp. 4125-4136
    • Alfieri, A.1    Srivastava, S.2    Siow, R.C.3    Modo, M.4    Fraser, P.A.5    Mann, G.E.6
  • 17
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • PMID: 24647116
    • Hayes JD, Dinkova-Kostova AT. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci. 2014; 39: 199-218. doi: 10.1016/j.tibs.2014.02.002 PMID: 24647116
    • (2014) Trends Biochem Sci , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 18
    • 84964999321 scopus 로고    scopus 로고
    • Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
    • PMID: 23951401
    • Holmstrom KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, et al. Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biol Open. 2013; 2: 761-770. doi: 10.1242/bio.20134853 PMID: 23951401
    • (2013) Biol Open , vol.2 , pp. 761-770
    • Holmstrom, K.M.1    Baird, L.2    Zhang, Y.3    Hargreaves, I.4    Chalasani, A.5    Land, J.M.6
  • 19
    • 0141621061 scopus 로고    scopus 로고
    • NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
    • PMID: 12842875
    • Lee JM, Shih AY, Murphy TH, Johnson JA. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem. 2003; 278: 37948-37956. PMID: 12842875
    • (2003) J Biol Chem , vol.278 , pp. 37948-37956
    • Lee, J.M.1    Shih, A.Y.2    Murphy, T.H.3    Johnson, J.A.4
  • 20
    • 84897411733 scopus 로고    scopus 로고
    • Genetic elimination of Nrf2 aggravates secondary complications except for vasospasm after experimental subarachnoid hemorrhage in mice
    • PMID: 24576487
    • Li T, Wang H, Ding Y, Zhou M, Zhou X, Zhang X, et al. Genetic elimination of Nrf2 aggravates secondary complications except for vasospasm after experimental subarachnoid hemorrhage in mice. Brain Res. 2014; 1558: 90-99. doi: 10.1016/j.brainres.2014.02.036 PMID: 24576487
    • (2014) Brain Res , vol.1558 , pp. 90-99
    • Li, T.1    Wang, H.2    Ding, Y.3    Zhou, M.4    Zhou, X.5    Zhang, X.6
  • 21
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • PMID: 22789539
    • Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell. 2012; 22: 66-79. doi: 10.1016/j.ccr.2012.05.016 PMID: 22789539
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3    Shibata, T.4    Nukiwa, T.5    Aburatani, H.6
  • 22
    • 84885793123 scopus 로고    scopus 로고
    • Effects of fumaric acid esters on blood-brain barrier tight junction proteins
    • PMID: 24076006
    • Benardais K, Pul R, Singh V, Skripuletz T, Lee DH, Linker RA, et al. Effects of fumaric acid esters on blood-brain barrier tight junction proteins. Neurosci Lett. 2013; 555: 165-170. doi: 10.1016/j.neulet.2013.09.038 PMID: 24076006
    • (2013) Neurosci Lett , vol.555 , pp. 165-170
    • Benardais, K.1    Pul, R.2    Singh, V.3    Skripuletz, T.4    Lee, D.H.5    Linker, R.A.6
  • 23
    • 84902436456 scopus 로고    scopus 로고
    • Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers
    • Wang X, Campos CR, Peart JC, Smith LK, Boni JL, Cannon RE, et al. Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers. J Neurosci. 2014; 4: 8585-8593.
    • (2014) J Neurosci , vol.4 , pp. 8585-8593
    • Wang, X.1    Campos, C.R.2    Peart, J.C.3    Smith, L.K.4    Boni, J.L.5    Cannon, R.E.6
  • 24
    • 34548850603 scopus 로고    scopus 로고
    • Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
    • PMID: 17881530
    • Zhao J, Moore AN, Redell JB, Dash PK. Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J Neurosci. 2007; 27: 10240-10248. PMID: 17881530
    • (2007) J Neurosci , vol.27 , pp. 10240-10248
    • Zhao, J.1    Moore, A.N.2    Redell, J.B.3    Dash, P.K.4
  • 25
    • 84884493497 scopus 로고    scopus 로고
    • Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke
    • PMID: 24017972
    • Alfieri A, Srivastava S, Siow RC, Cash D, Modo M, Duchen MR, et al. Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke. Free Radic Biol Med. 2013; 65: 1012-1022. doi: 10.1016/j.freeradbiomed.2013.08.190 PMID: 24017972
    • (2013) Free Radic Biol Med , vol.65 , pp. 1012-1022
    • Alfieri, A.1    Srivastava, S.2    Siow, R.C.3    Cash, D.4    Modo, M.5    Duchen, M.R.6
  • 26
    • 84856465375 scopus 로고    scopus 로고
    • Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress
    • PMID: 22293557
    • Crunkhorn S. Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress. Nat Rev Drug Discov. 2012; 11: 96. doi: 10.1038/nrd3655 PMID: 22293557
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 96
    • Crunkhorn, S.1
  • 27
    • 84880063584 scopus 로고    scopus 로고
    • Seven in absentia homolog 2 (Siah2) protein is a regulator of NF-E2-related factor 2 (Nrf2)
    • PMID: 23645672
    • Baba K, Morimoto H, Imaoka S. Seven in absentia homolog 2 (Siah2) protein is a regulator of NF-E2-related factor 2 (Nrf2). J Biol Chem. 2013; 288: 18393-18405. doi: 10.1074/jbc.M112.438762 PMID: 23645672
    • (2013) J Biol Chem , vol.288 , pp. 18393-18405
    • Baba, K.1    Morimoto, H.2    Imaoka, S.3
  • 28
    • 0013282861 scopus 로고    scopus 로고
    • Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome
    • PMID: 12446695
    • Nguyen T, Sherratt PJ, Huang HC, Yang CS, Pickett CB. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem. 2003; 278: 4536-4541. PMID: 12446695
    • (2003) J Biol Chem , vol.278 , pp. 4536-4541
    • Nguyen, T.1    Sherratt, P.J.2    Huang, H.C.3    Yang, C.S.4    Pickett, C.B.5
  • 29
    • 84861464050 scopus 로고    scopus 로고
    • Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging
    • PMID: 22575091
    • Chapple SJ, Siow RC, Mann GE. Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. Int J Biochem Cell Biol. 2012; 44: 1315-1320. doi: 10.1016/j.biocel.2012.04.021 PMID: 22575091
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1315-1320
    • Chapple, S.J.1    Siow, R.C.2    Mann, G.E.3
  • 30
    • 27744460321 scopus 로고    scopus 로고
    • Blood-brain barrier-specific properties of a human adult brain endothelial cell line
    • PMID: 16141364
    • Weksler BB, Subileau EA, Perriere N, Charneau P, Holloway K, Leveque M, et al. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J. 2005; 19: 1872-1874. PMID: 16141364
    • (2005) FASEB J , vol.19 , pp. 1872-1874
    • Weksler, B.B.1    Subileau, E.A.2    Perriere, N.3    Charneau, P.4    Holloway, K.5    Leveque, M.6
  • 31
    • 84874884743 scopus 로고    scopus 로고
    • A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders
    • PMID: 23437435
    • Lincoln KM, Gonzalez P, Richardson TE, Julovich DA, Saunders R, Simpkins JW, et al. A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders. Chem Commun (Camb). 2013; 49: 2712-2714. doi: 10.1039/c2cc36808k PMID: 23437435
    • (2013) Chem Commun (Camb) , vol.49 , pp. 2712-2714
    • Lincoln, K.M.1    Gonzalez, P.2    Richardson, T.E.3    Julovich, D.A.4    Saunders, R.5    Simpkins, J.W.6
  • 32
    • 84896725023 scopus 로고    scopus 로고
    • The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells
    • PMID: 24346691
    • Artus C, Glacial F, Ganeshamoorthy K, Ziegler N, Godet M, Guilbert T, et al. The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab. 2014; 34: 433-440. doi: 10.1038/jcbfm.2013.213 PMID: 24346691
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 433-440
    • Artus, C.1    Glacial, F.2    Ganeshamoorthy, K.3    Ziegler, N.4    Godet, M.5    Guilbert, T.6
  • 33
    • 84872159164 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model
    • PMID: 23137377
    • Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, et al. Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm. 2013; 10: 289-296. doi: 10.1021/mp3004308 PMID: 23137377
    • (2013) Mol Pharm , vol.10 , pp. 289-296
    • Ohtsuki, S.1    Ikeda, C.2    Uchida, Y.3    Sakamoto, Y.4    Miller, F.5    Glacial, F.6
  • 34
    • 84904463126 scopus 로고    scopus 로고
    • Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells
    • PMID: 25033388
    • Toth AE, Walter FR, Bocsik A, Santha P, Veszelka S, Nagy L,et al. Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells. PLoS One 2014; 9: e100152. doi: 10.1371/journal.pone.0100152 PMID: 25033388
    • (2014) PLoS One , vol.9 , pp. e100152
    • Toth, A.E.1    Walter, F.R.2    Bocsik, A.3    Santha, P.4    Veszelka, S.5    Nagy, L.6
  • 35
    • 79959600649 scopus 로고    scopus 로고
    • Acute hypoglycemia induces retinal cell death in mouse
    • PMID: 21738719
    • Emery M, Schorderet DF, Roduit R. Acute hypoglycemia induces retinal cell death in mouse. PLoS One 2011; 6: e21586. doi: 10.1371/journal.pone.0021586 PMID: 21738719
    • (2011) PLoS One , vol.6 , pp. e21586
    • Emery, M.1    Schorderet, D.F.2    Roduit, R.3
  • 36
    • 84889092945 scopus 로고    scopus 로고
    • Chromium modulates expressions of neuronal plasticity markers and glial fibrillary acidic proteins in hypoglycemia-induced brain injury
    • PMID: 24157456
    • Sahin K, Tuzcu M, Orhan C, Ali S, Sahin N, Gencoglu H, et al. Chromium modulates expressions of neuronal plasticity markers and glial fibrillary acidic proteins in hypoglycemia-induced brain injury. Life Sci. 2013; 93: 1039-1048. doi: 10.1016/j.lfs.2013.10.009 PMID: 24157456
    • (2013) Life Sci , vol.93 , pp. 1039-1048
    • Sahin, K.1    Tuzcu, M.2    Orhan, C.3    Ali, S.4    Sahin, N.5    Gencoglu, H.6
  • 37
    • 84896725023 scopus 로고    scopus 로고
    • The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells
    • PMID: 24346691
    • Artus C, Glacial F, Ganeshamoorthy K, Ziegler N, Godet M, Guilbert T, et al. The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab. 2014; 34: 433-440. doi: 10.1038/jcbfm.2013.213 PMID: 24346691
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 433-440
    • Artus, C.1    Glacial, F.2    Ganeshamoorthy, K.3    Ziegler, N.4    Godet, M.5    Guilbert, T.6
  • 38
    • 45549102801 scopus 로고    scopus 로고
    • Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier
    • PMID: 18258663
    • Forster C, Burek M, Romero IA, Weksler B, Couraud PO, Drenckhahn D. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008; 586: 1937-1949. doi: 10.1113/jphysiol.2007.146852 PMID: 18258663
    • (2008) J Physiol , vol.586 , pp. 1937-1949
    • Forster, C.1    Burek, M.2    Romero, I.A.3    Weksler, B.4    Couraud, P.O.5    Drenckhahn, D.6
  • 39
    • 84900399375 scopus 로고    scopus 로고
    • Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: Is smoking reduced or nicotine-free products really safe?
    • PMID: 24755281
    • Naik P, Fofaria N, Prasad S, Sajja RK, Weksler B, Couraud PO, et al. Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? BMC Neurosci. 2014; 15: 51. doi: 10.1186/1471-2202-15-51 PMID: 24755281
    • (2014) BMC Neurosci , vol.15 , pp. 51
    • Naik, P.1    Fofaria, N.2    Prasad, S.3    Sajja, R.K.4    Weksler, B.5    Couraud, P.O.6
  • 40
    • 84868249383 scopus 로고    scopus 로고
    • Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier
    • PMID: 23068604
    • Daniels BP, Cruz-Orengo L, Pasieka TJ, Couraud PO, Romero IA, Weksler B, et al. Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier. J Neurosci Methods 2013; 212: 173-179. doi: 10.1016/j.jneumeth.2012.10.001 PMID: 23068604
    • (2013) J Neurosci Methods , vol.212 , pp. 173-179
    • Daniels, B.P.1    Cruz-Orengo, L.2    Pasieka, T.J.3    Couraud, P.O.4    Romero, I.A.5    Weksler, B.6
  • 41
    • 38549096764 scopus 로고    scopus 로고
    • Immortalized human brain endothelial cells and flow-based vascular modeling: A marriage of convenience for rational neurovascular studies
    • PMID: 17609686
    • Cucullo L, Couraud PO, Weksler B, Romero IA, Hossain M, Rapp E, et al. Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab. 2008; 28: 312-328. PMID: 17609686
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 312-328
    • Cucullo, L.1    Couraud, P.O.2    Weksler, B.3    Romero, I.A.4    Hossain, M.5    Rapp, E.6
  • 42
    • 2942731503 scopus 로고    scopus 로고
    • Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
    • PMID: 15210114
    • Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell. 2004; 117: 941-952. PMID: 15210114
    • (2004) Cell , vol.117 , pp. 941-952
    • Nakayama, K.1    Frew, I.J.2    Hagensen, M.3    Skals, M.4    Habelhah, H.5    Bhoumik, A.6
  • 43
    • 0037648580 scopus 로고    scopus 로고
    • Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    • PMID: 12743111
    • Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003; 161: 653-660. PMID: 12743111
    • (2003) J Cell Biol , vol.161 , pp. 653-660
    • Nitta, T.1    Hata, M.2    Gotoh, S.3    Seo, Y.4    Sasaki, H.5    Hashimoto, N.6
  • 44
    • 4644271738 scopus 로고    scopus 로고
    • Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP
    • PMID: 15383327
    • Soma T, Chiba H, Kato-Mori Y, Wada T, Yamashita T, Kojima T, et al. Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP. Exp Cell Res. 2004; 300: 202-212. PMID: 15383327
    • (2004) Exp Cell Res , vol.300 , pp. 202-212
    • Soma, T.1    Chiba, H.2    Kato-Mori, Y.3    Wada, T.4    Yamashita, T.5    Kojima, T.6
  • 45
    • 79960755029 scopus 로고    scopus 로고
    • Tight junctions in brain barriers during central nervous system inflammation
    • PMID: 21338320
    • Coisne C, Engelhardt B. Tight junctions in brain barriers during central nervous system inflammation. Antioxid Redox Signal. 2011; 15: 1285-1303. doi: 10.1089/ars.2011.3929 PMID: 21338320
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1285-1303
    • Coisne, C.1    Engelhardt, B.2
  • 46
    • 84858153711 scopus 로고    scopus 로고
    • Oxidative stress and cerebral endothelial cells: Regulation of the blood-brain-barrier and antioxidant based interventions
    • PMID: 22206999
    • Freeman LR, Keller JN. Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions. Biochim Biophys Acta. 2012; 1822: 822-829. doi: 10.1016/j.bbadis.2011.12.009 PMID: 22206999
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 822-829
    • Freeman, L.R.1    Keller, J.N.2
  • 47
    • 22844450096 scopus 로고    scopus 로고
    • Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
    • PMID: 15917255
    • Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, et al. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. J Biol Chem. 2005; 280: 27244-27250. PMID: 15917255
    • (2005) J Biol Chem , vol.280 , pp. 27244-27250
    • Hosoya, T.1    Maruyama, A.2    Kang, M.I.3    Kawatani, Y.4    Shibata, T.5    Uchida, K.6
  • 48
    • 48649101326 scopus 로고    scopus 로고
    • Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    • PMID: 18604199
    • Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol. 2008; 10: 923-934. doi: 10.1038/ncb1752 PMID: 18604199
    • (2008) Nat Cell Biol , vol.10 , pp. 923-934
    • Taddei, A.1    Giampietro, C.2    Conti, A.3    Orsenigo, F.4    Breviario, F.5    Pirazzoli, V.6
  • 49
    • 79958176472 scopus 로고    scopus 로고
    • Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability
    • PMID: 21552771
    • Pang H, Yi P, Wu P, Liu Z, Liu Z, Gong J, et al. Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability. ScientificWorldJournal 2011; 11: 1056-1067. doi: 10.1100/tsw.2011.98 PMID: 21552771
    • (2011) ScientificWorldJournal , vol.11 , pp. 1056-1067
    • Pang, H.1    Yi, P.2    Wu, P.3    Liu, Z.4    Liu, Z.5    Gong, J.6
  • 50
    • 79953092806 scopus 로고    scopus 로고
    • Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
    • PMID: 21426580
    • Abdul Muneer PM, Alikunju S, Szlachetka AM, Murrin LC, Haorah J. Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction. Mol Neurodegener. 2011; 6: 23. doi: 10.1186/1750-1326-6-23 PMID: 21426580
    • (2011) Mol Neurodegener , vol.6 , pp. 23
    • Abdul Muneer, P.M.1    Alikunju, S.2    Szlachetka, A.M.3    Murrin, L.C.4    Haorah, J.5
  • 51
    • 84855252878 scopus 로고    scopus 로고
    • Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR
    • PMID: 21878739
    • Terashima J, HabanoW, Gamou T, Ozawa S. Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR. Drug Metab Pharmacokinet. 2011; 26: 577-583. doi: 10.2133/dmpk.DMPK-11-RG-054 PMID: 21878739
    • (2011) Drug Metab Pharmacokinet , vol.26 , pp. 577-583
    • Terashima, J.1    Habano, W.2    Gamou, T.3    Ozawa, S.4


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