Systolic hypertension: An increasing clinical challenge in Asia

Hypertension Research

Volumn 38, Issue 4, 2015, Pages 227-236

  Park, Jeong Bae ^a   Kario, Kazuomi ^b   Wang, Ji Guang ^c  

^a Kwandong University College of Medicine   (South Korea)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

aging; antihypertensive agents; Asians; cardiovascular diseases; vascular stiffness

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; THIAZIDE DIURETIC AGENT; VASODILATOR AGENT;

ARTERIAL STIFFNESS; ASIA; AWARENESS; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; HUMAN; KIDNEY FUNCTION; MORTALITY; OBESITY; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; REVIEW; SALT INTAKE; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; AGING; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; HEALTH EDUCATION; HYPERTENSION; MALE; MIDDLE AGED; RISK FACTOR;

AGING; ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; HEALTH EDUCATION; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; RISK FACTORS;

EID: 84926650966     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2014.169     Document Type: Review

References (136)

1. WHO Global Health Observatory. Prevalence of raised blood pressure: situations and trends. http://www.who.int/gho/ncd/risk-factors/blood-pressure-prevalence-text/en/ (accessed 10 June 2014).
2. Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens 2004; 22: 11-19.
3. World Health Organization Prevalence of raised blood pressure, ages 25+, 2008. http:// gamapserver.who.int/gho/interactive-charts/ncd/risk-factors/blood-pressure-prevalence/ atlas.html (accessed 10 June 2014).
4. Sheng CS, Liu M, Kang YY, Wei FF, Zhang L, Li GL, Dong Q, Huang QF, Li Y, Wang JG. Prevalence, awareness, treatment and control of hypertension in elderly Chinese. Hypertens Res 2013; 36: 824-828.
5. Davarian S, Crimmins E, Takahashi A, Saito Y. Sociodemographic correlates of four indices of blood pressure and hypertension among older persons in Japan. Gerontology 2013; 59: 392-400.
6. Li YC, Wang LM, Jiang Y, Li XY, Zhang M, Hu N. Prevalence of hypertension among Chinese adults in 2010. Zhonghua Yu Fang Yi Xue Za Zhi 2012; 46: 409-413 [in Chinese].
7. Gupta R, Sharma KK, Gupta A, Agrawal A, Mohan I, Gupta VP, Khedar RS, Guptha S. Persistent high prevalence of cardiovascular risk factors in the urban middle class in India: Jaipur Heart Watch-5. J Assoc Physicians India 2012; 60: 11-16.
8. Lee JH, Yang DH, Park HS, Cho Y, Jun JE, Park WH, Chun BY, Shin JY, Shin DH, Lee KS, Kim KS, Kim KB, Kim YJ, Chae SC. Incidence of hypertension in Korea: 5-year follow-up study. J Korean Med Sci 2011; 26: 1286-1292.
9. Chiang CE, Wang TD, Li YH, Lin TH, Chien KL, Yeh HI, Shyu KG, Tsai WC, Chao TH, Hwang JJ, Chiang FT, Chen JH. 2010 guidelines of the Taiwan Society of Cardiology for the management of hypertension. J Formos Med Assoc 2010; 109: 740-773.
10. Chung N, Baek S, Chen MF, Liau CS, Park CG, Park J, Saruta T, Shimamoto K, Wu Z, Zhu J, Fujita T. Expert recommendations on the challenges of hypertension in Asia. Int J Clin Pract 2008; 62: 1306-1312.
11. Kario K. Proposal of a new strategy for ambulatory blood pressure profile-based management of resistant hypertension in the era of renal denervation. Hypertens Res 2013; 36: 564.
12. Kang DG, Jeong MH, Ahn Y, Chae SC, Hur SH, Hong TJ, Kim YJ, Seong IW, Chae JK, Rhew JY, Chae IH, Cho MC, Bae JH, Rha SW, Kim CJ, Jang YS, Yoon J, Seung KB, Park SJ. Clinical effects of hypertension on the mortality of patients with acute myocardial infarction. J Korean Med Sci 2009; 24: 800-806.
13. Shimamoto K, Fujita T, Ito S, Naritomi H, Ogihara T, Shimada K, Tanaka H, Yoshiike N. Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients: the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a prospective nationwide observational study. Hypertens Res 2008; 31: 469-478.
14. Yang X, Sun K, Zhang W, Wu H, Zhang H, Hui R. Prevalence of and risk factors for peripheral arterial disease in the patients with hypertension among Han Chinese. J Vasc Surg 2007; 46: 296-302.
15. Arima H, Murakami Y, Lam TH, Kim HC, Ueshima H, Woo J, Suh I, Fang X, Woodward M. Effects of prehypertension and hypertension subtype on cardiovascular disease in the Asia-Pacific Region. Hypertension 2012; 59: 1118-1123.
16. Kengne AP, Patel A, Barzi F, Jamrozik K, Lam TH, Ueshima H, Gu DF, Suh I, Woodward M. Systolic blood pressure, diabetes and the risk of cardiovascular diseases in the Asia-Pacific region. J Hypertens 2007; 25: 1205-1213.
17. Franklin SS, Jacobs MJ, Wong ND, L'Italien GJ, Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III. Hypertension 2001; 37: 869-874.
18. Perkovic V, Huxley R, Wu Y, Prabhakaran D, MacMahon S. The burden of blood pressure-related disease: a neglected priority for global health. Hypertension 2007; 50: 991-997.
19. Ueshima H. Explanation for the Japanese paradox: prevention of increase in coronary heart disease and reduction in stroke. J Atheroscler Thromb 2007; 14: 278-286.
20. Ishikawa Y, Ishikawa J, Ishikawa S, Kajii E, Schwartz JE, Pickering TG, Kario K. Prehypertension and the risk for cardiovascular disease in the Japanese general population: the Jichi Medical School Cohort Study. J Hypertens 2010; 28: 1630-1637.
21. Okada H, Fukui M, Tanaka M, Matsumoto S, Mineoka Y, Nakanishi N, Tomiyasu K, Nakano K, Hasegawa G, Nakamura N. Visit-to-visit variability in systolic blood pressure is a novel risk factor for the progression of coronary artery calcification. Hypertens Res 2013; 36: 996-999.
22. Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895-905.
23. Duprez DA. Systolic hypertension in the elderly: addressing an unmet need. Am J Med 2008; 121: 179-184.
24. Williams B, Lindholm LH, Sever P. Systolic pressure is all that matters. Lancet 2008; 371: 2219-2221.
25. Asia Pacific Cohort Studies Collaboration. The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease. Int J Epidemiol 2006; 35: 1025-1033.
26. He S, Chen XP, Chen XN, Li LX, Wan LY, Peng Y, Gong L, Cui CJ, Zhu Y, Huang DJ. Changes of prevalence of hypertension and blood pressure levels in 1061 adults in Chengdu from 1992 to 2007. Sichuan Da Xue Xue Bao Yi Xue Ban 2010; 41: 494-497 535.
27. Li J, Xu C, Sun Z, Zheng L, Li J, Zhang D, Zhang X, Liu S, Zhao F, Hu D, Sun Y. Prevalence and risk factors for isolated untreated systolic hypertension in rural Mongolian and Han populations. Acta Cardiol 2008; 63: 389-393.
28. Kim JA, Kim SM, Choi YS, Yoon D, Lee JS, Park HS, Kim HA, Lee J, Oh HJ, Choi KM. The prevalence and risk factors associated with isolated untreated systolic hypertension in Korea: the Korean National Health and Nutrition Survey 2001. J Hum Hypertens 2007; 21: 107-113.
29. Kim BG, Park JT, Ahn Y, Kimm K, Shin C. Geographical difference in the prevalence of isolated systolic hypertension in middle-aged men and women in Korea: the Korean Health and Genome Study. J Human Hypertens 2005; 19: 877-883.
30. Midha T, Idris MZ, Saran RK, Srivastava AK, Singh SK. Isolated systolic hypertension and its determinants - a cross-sectional study in the adult population of Lucknow District in North India. Indian J Community Med 2010; 35: 89-93.
31. Ruixing Y, Hui L, Jinzhen W, Weixiong L, Dezhai Y, Shangling P, Jiandong H, Xiuyan L. Association of diet and lifestyle with blood pressure in the Guangxi Hei Yi Zhuang and Han populations. Public Health Nutr 2009; 12: 553-561.
32. Wang J, Ning X, Yang L, Lu H, Tu J, Jin W, Zhang W, Su TC. Trends of hypertension prevalence, awareness, treatment and control in rural areas of northern China during 1991-2011. J Hum Hypertens 2014; 28: 25-31.
33. Park S, Lakatta EG. Role of inflammation in the pathogenesis of arterial stiffness. Yonsei Med J 2012; 53: 258-261.
34. Oparil S, Zaman MA, Calhoun DA. Pathogenesis of hypertension. Ann Intern Med 2003; 139: 761-776.
35. Gardner DG, Chen S, Glenn DJ, Grigsby CL. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension 2007; 49: 419-426.
36. Pandey KN. Emerging roles of natriuretic peptides and their receptors in pathophysiology of hypertension and cardiovascular regulation. J Am Soc Hypertens 2008; 2: 210-226.
37. Rubattu S, Sciarretta S, Valenti V, Stanzione R, Volpe M. Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases. Am J Hypertens 2008; 21: 733-741.
38. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 2012; 308: 875-881.
39. Izzo JL Jr, Shykoff BE. Arterial stiffness: clinical relevance, measurement, and treatment. Rev Cardiovasc Med 2001; 2: 29-34 37-40.
40. Meenakshisundaram R, Kamaraj K, Murugan S, Thirumalaikolundusubramanian P. Aortic stiffness and distensibility among hypertensives. Ann NY Acad Sci 2009; 1173: E68-E71.
41. Xu TY, Li Y, Wang YQ, Li YX, Zhang Y, Zhu DL, Gao PJ. Association of stroke with ambulatory arterial stiffness index (AASI) in hypertensive patients. Clin Exp Hypertens 2011; 33: 304-308.
42. Wang KL, Cheng HM, Sung SH, Chuang SY, Li CH, Spurgeon HA, Ting CT, Najjar SS, Lakatta EG, Yin FC, Chou P, Chen CH. Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a communitybased study. Hypertension 2010; 55: 799-805.
43. Ohishi M, Tatara Y, Ito N, Takeya Y, Onishi M, Maekawa Y, Kato N, Kamide K, Rakugi H. The combination of chronic kidney disease and increased arterial stiffness is a predictor for stroke and cardiovascular disease in hypertensive patients. Hypertens Res 2011; 34: 1209-1215.
44. Matsuoka O, Otsuka K, Murakami S, Hotta N, Yamanaka G, Kubo Y, Yamanaka T, Shinagawa M, Nunoda S, Nishimura Y, Shibata K, Saitoh H, Nishinaga M, Ishine M, Wada T, Okumiya K, Matsubayashi K, Yano S, Ichihara K, Cornelissen G, Halberg F, Ozawa T. Arterial stiffness independently predicts cardiovascular events in an elderly community - Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study. Biomed Pharmacother 2005; 59 (Suppl 1): S40-S44.
45. Shoji T, Emoto M, Shinohara K, Kakiya R, Tsujimoto Y, Kishimoto H, Ishimura E, Tabata T, Nishizawa Y. Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol 2001; 12: 2117-2124.
46. Tomiyama H, Koji Y, Yambe M, Shiina K, Motobe K, Yamada J, Shido N, Tanaka N, Chikamori T, Yamashina A. Brachial - ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome. Circ J 2005; 69: 815-822.
47. Tomiyama H, Tanaka H, Hashimoto H, Matsumoto C, Odaira M, Yamada J, Yoshida M, Shiina K, Nagata M, Yamashina A. Arterial stiffness and declines in individuals with normal renal function/early chronic kidney disease. Atherosclerosis 2010; 212: 345-350.
48. Stamler J. The INTERSALT Study: background, methods, findings, and implications. Am J Clin Nutr 1997; 65: 626S-642S.
49. Strazzullo P, D'Elia L, Kandala NB, Cappuccio FP. Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ 2009; 339: b4567.
50. Miura K, Okuda N, Turin TC, Takashima N, Nakagawa H, Nakamura K, Yoshita K, Okayama A, Ueshima H. Dietary salt intake and blood pressure in a representative Japanese population: baseline analyses of NIPPON DATA80. J Epidemiol 2010; 20 (Suppl 3): S524-S530.
51. Radhika G, Sathya RM, Sudha V, Ganesan A, Mohan V. Dietary salt intake and hypertension in an urban south Indian population-[CURES - 53]. J Assoc Physicians India 2007; 55: 405-411.
52. Zheng L, Sun Z, Zhang X, Xu C, Li J, Hu D, Sun Y. Predictors of progression from prehypertension to hypertension among rural Chinese adults: results from Liaoning Province. Eur J Cardiovasc Prev Rehabil 2010; 17: 217-222.
53. Kawano Y, Ando K, Matsuura H, Tsuchihashi T, Fujita T, Ueshima H. Report of the Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension: (1) rationale for salt restriction and salt-restriction target level for the management of hypertension. Hypertens Res 2007; 30: 879-886.
54. Hu HH, Sheng WY, Chu FL, Lan CF, Chiang BN. Incidence of stroke in Taiwan. Stroke 1992; 23: 1237-1241.
55. Nagata C, Takatsuka N, Shimizu N, Shimizu H. Sodium intake and risk of death from stroke in Japanese men and women. Stroke 2004; 35: 1543-1547.
56. Umesawa M, Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Kondo T, Inaba Y, Tanabe N, Tamakoshi A. Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer Risks. Am J Clin Nutr 2008; 88: 195-202.
57. Park S, Park JB, Lakatta EG. Association of central hemodynamics with estimated 24-h urinary sodium in patients with hypertension. J Hypertens 2011; 29: 1502-1507.
58. Starmans-Kool MJ, Stanton AV, Xu YY, SAMcG Thom, Parker KH, Hughes AD. High dietary salt intake increases carotid blood pressure and wave reflection in normotensive healthy young men. J Appl Physiol (1985) 2011; 110: 468-471.
59. Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol 2013; 61: 335-343.
60. Zhou B, Wang HL, Wang WL, Wu XM, Fu LY, Shi JP. Long-term effects of salt substitution on blood pressure in a rural north Chinese population. J Hum Hypertens 2013; 27: 427-433.
61. He FJ, Marciniak M, Visagie E, Markandu ND, Anand V, Dalton RN, MacGregor GA. Effect of modest salt reduction on blood pressure, urinary albumin, and pulse wave velocity in white, black, and Asian mild hypertensives. Hypertension 2009; 54: 482-488.
62. He J, Gu D, Chen J, Jaquish CE, Rao DC, Hixson JE, Chen JC, Duan X, Huang JF, Chen CS, Kelly TN, Bazzano LA, Whelton PK. Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study. J Hypertens 2009; 27: 48-54.
63. Zhang X, Yao S, Sun G, Yu S, Sun Z, Zheng L, Xu C, Li J, Sun Y. Total and abdominal obesity among rural Chinese women and the association with hypertension. Nutrition 2012; 28: 46-52.
64. Lee HS, Park YM, Kwon HS, Lee JH, Yoon KH, Son HY, Kim DS, Yim HW, Lee WC. Factors associated with control of blood pressure among elderly people diagnosed with hypertension in a rural area of South Korea: the Chungju Metabolic Disease Cohort Study (CMC study). Blood Press 2010; 19: 31-39.
65. Kawamoto R, Kohara K, Tabara Y, Miki T. High prevalence of prehypertension is associated with the increased body mass index in community-dwelling Japanese. Tohoku J Exp Med 2008; 216: 353-361.
66. Ishikawa Y, Ishikawa J, Ishikawa S, Kayaba K, Nakamura Y, Shimada K, Kajii E, Pickering TG, Kario K. Prevalence and determinants of prehypertension in a Japanese general population: the Jichi Medical School Cohort Study. Hypertens Res 2008; 31: 1323-1330.
67. Greenlund KJ, Croft JB, Mensah GA. Prevalence of heart disease and stroke risk factors in persons with prehypertension in the United States, 1999-2000. Arch Intern Med 2004; 164: 2113-2118.
68. Kubo M, Hata J, Doi Y, Tanizaki Y, Lida M, Kiyohara Y. Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population. Circulation 2008; 118: 2672-2678.
69. Uzu T, Kimura G, Yamauchi A, Kanasaki M, Isshiki K, Araki S, Sugiomoto T, Nishio Y, Maegawa H, Koya D, Haneda M, Kashiwagi A. Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension. J Hypertens 2006; 24: 1627-1632.
70. Chen J, Gu D, Huang J, Rao DC, Jaquish CE, Hixson JE, Chen CS, Chen J, Lu F, Hu D, Rice T, Kelly TN, Hamm LL, Whelton PK, He J. Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study. Lancet 2009; 373: 829-835.
71. Woodward M, Tsukinoki-Murakami R, Murakami Y, Suh I, Fang X, Ueshima H, Lam TH. The epidemiology of stroke amongst women in the Asia-Pacific region. Womens Health (Lond Engl) 2011; 7: 305-317.
72. Woodward M, Huxley H, Lam TH, Barzi F, Lawes CM, Ueshima H. Asia Pacific Cohort Studies Collaboration. A comparison of the associations between risk factors and cardiovascular disease in Asia and Australasia. Eur J Cardiovasc Prev Rehabil 2005; 12: 484-491.
73. Lawes CM, Rodgers A, Bennett DA, Parag V, Suh I, Ueshima H, MacMahon S. Blood pressure and cardiovascular disease in the Asia Pacific region. J Hypertens 2003; 21: 707-716.
74. Nakamura K, Barzi F, Lam TH, Huxley R, Feigin VL, Ueshima H, Woo J, Gu D, Ohkubo T, Lawes CM, Suh I, Woodward M. Cigarette smoking, systolic blood pressure, and cardiovascular diseases in the Asia-Pacific region. Stroke 2008; 39: 1694-1702.
75. Ishikawa S, Kario K, Kayaba K, Gotoh T, Nago N, Nakamura Y, Tsutsumi A, Kajii E. Linear relationship between blood pressure and stroke: the Jichi Medical School Cohort Study. J Clin Hypertens (Greenwich) 2007; 9: 677-683.
76. Feigin V, Parag V, Lawes CM, Rodgers A, Suh I, Woodward M, Jamrozik K, Ueshima H. Smoking and elevated blood pressure are the most important risk factors for subarachnoid hemorrhage in the Asia-Pacific region: an overview of 26 cohorts involving 306,620 participants. Stroke 2005; 36: 1360-1365.
77. Sauvaget C, Ramadas K, Thomas G, Thara S, Sankaranarayanan R. Prognosis criteria of casual systolic and diastolic blood pressure values in a prospective study in India. J Epidemiol Community Health 2010; 64: 366-372.
78. O'Seaghdha CM, Perkovic V, Lam TH, McGinn S, Barzi F, Gu DF, Cass A, Suh I, Muntner P, Giles GG, Ueshima H, Woodward M, Huxley R. Blood pressure is a major risk factor for renal death: an analysis of 560 352 participants from the Asia- Pacific region. Hypertension 2009; 54: 509-515.
79. Ogihara T, Nakao K, Fukui T, Fukiyama K, Fujimoto A, Ueshima K, Oba K, Shimamoto K, Matsuoka H, Saruta T. The optimal target blood pressure for antihypertensive treatment in Japanese elderly patients with high-risk hypertension: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. Hypertens Res 2008; 31: 1595-1601.
80. Kagiyama S, Fukuhara M, Ansai T, Matsumura K, Soh I, Takata Y, Sonoki K, Awano S, Takehara T, Iida M. Association between blood pressure and mortality in 80-year-old subjects from a population-based prospective study in Japan. Hypertens Res 2008; 31: 265-270.
81. Huxley R, Woodward M, Barzi F, Wong JW, Pan WH, Patel A; Asia Pacific Cohort Studies Collaboration. Does sex matter in the associations between classic risk factors and fatal coronary heart disease in populations from the Asia-Pacific region? J Womens Health (Larchmt) 2005; 14: 820-828.
82. Liu L, Wang JG, Gong L, Liu G, Staessen JA. Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group. J Hypertens 1998; 16: 1823-1829.
83. Wang JG, Staessen JA, Gong L, Liu L. Chinese trial on isolated systolic hypertension in the elderly. Systolic Hypertension in China (Syst-China) Collaborative Group. Arch Intern Med 2000; 160: 211-220.
84. Liu L, Zhang Y, Liu G, Li W, Zhang X, Zanchetti A; FEVER Study Group. The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebocontrolled trial in Chinese hypertensive patients. J Hypertens 2005; 23: 2157-2172.
85. Ratnasabapathy Y, Lawes CM, Anderson CS. The Perindopril Protection Against Recurrent Stroke Study (PROGRESS): clinical implications for older patients with cerebrovascular disease. Drugs Aging 2003; 20: 241-251.
86. Matsuzaki M, Ogihara T, Umemoto S, Rakugi H, Matsuoka H, Shimada K, Abe K, Suzuki N, Eto T, Higaki J, Ito S, Kamiya A, Kikuchi K, Suzuki H, Tei C, Ohashi Y, Saruta T. Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension: a randomized controlled trial. J Hypertens 2011; 29: 1649-1659.
87. Yui Y, Sumiyoshi T, Kodama K, Hirayama A, Nonogi H, Kanmatsuse K, Origasa H, Iimura O, Ishii M, Saruta T, Arakawa K, Hosoda S, Kawai C. Comparison of nifedipine retard with angiotensin converting enzyme inhibitors in Japanese hypertensive patients with coronary artery disease: the Japan Multicenter Investigation for Cardiovascular Diseases-B (JMIC-B) randomized trial. Hypertens Res 2004; 27: 181-191.
88. Ogihara T. Practitioner's trial on the efficacy of antihypertensive treatment in the elderly hypertension (the PATE-Hypertension Study) in Japan. Am J Hypertens 2000; 13: 461-467.
89. Ogihara T, Saruta T, Matsuoka H, Shimamoto K, Fujita T, Shimada K, Imai Y, Nishigaki M. Valsartan in elderly isolated systolic hypertension (VALISH) study: rationale and design. Hypertens Res 2004; 27: 657-661.
90. Ogihara T, Saruta T, Rakugi H, Matsuoka H, Shimamoto K, Shimada K, Imai Y, Kikuchi K, Ito S, Eto T, Kimura G, Imaizumi T, Takishita S, Ueshima H. Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study. Hypertension 2010; 56: 196-202.
91. JATOS Study Group. Principal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS). Hypertens Res 2008; 31: 2115-2127.
92. Fujita T, Wu Z, Park J-B, Chen M-F. Briefings on JHS, CHS, KHS and THS guidelines and their difference from JNC VII and ESC/ESH. Int J Clin Pract 2006; 60: 3-6.
93. Morgan T. Hypertension in the Asian Pacific region: the problem and the solution http://www.apsh.org/Beij-report.doc (accessed 10 June 2014).
94. National Heart, Lung, and Blood Institute, US Department of Health and Human Services. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure http://www.nhlbi.nih.gov/guidelines/ hypertension/jnc7full.pdf (accessed 10 June 2014).
95. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, Christiaens T, Cifkova R, De BG, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31: 1281-1357.
96. Liu LS. Writing Group of 2010. Chinese guidelines for the management of hypertension. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39: 579-615.
97. Park JB. 2004 Korean hypertension treatment guideline and its perspective. Korean Circulation J 2006; 36: 405-410.
98. Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu T, Ito M, Ito S, Itoh H, Iwao H, Kai H, Kario K, Kashihara N, Kawano Y, Kim-Mitsuyama S, Kimura G, Kohara K, Komuro I, Kumagai H, Matsuura H, Miura K, Morishita R, Naruse M, Node K, Ohya Y, Rakugi H, Saito I, Saitoh S, Shimada K, Shimosawa T, Suzuki H, Tamura K, Tanahashi N, Tsuchihashi T, Uchiyama M, Ueda S, Umemura S. Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res 2014; 37: 253-387.
99. Wang L. Physician-related barriers to hypertension management. Med Princ Pract 2004; 13: 282-285.
100. Cheng H. Prescribing pattern of antihypertensive drugs in a general hospital in central China. Int J Clin Pharm 2011; 33: 215-220.
101. Wang JG, Kario K, Lau T, Wei YQ, Park CG, Kim CH, Huang J, Zhang W, Li Y, Yan P, Hu D. Use of dihydropyridine calcium channel blockers in the management of hypertension in Eastern Asians: a scientific statement from the Asian Pacific Heart Association. Hypertens Res 2011; 34: 423-430.
102. Mori H, Ukai H, Yamamoto H, Saitou S, Hirao K, Yamauchi M, Umemura S. Current status of antihypertensive prescription and associated blood pressure control in Japan. Hypertens Res 2006; 29: 143-151.
103. Huang LY, Shau WY, Chen HC, Su S, Yang MC, Yeh HL, Lai MS. Pattern analysis and variations in the utilization of antihypertensive drugs in Taiwan: a six-year study. Eur Rev Med Pharmacol Sci 2013; 17: 410-419.
104. Liu PH, Wang JD. Antihypertensive medication prescription patterns and time trends for newly-diagnosed uncomplicated hypertension patients in Taiwan. BMC Health Serv Res 2008; 8: 133.
105. Sung SK, Lee SG, Lee KS, Kim DS, Kim KH, Kim KY. First-year treatment adherence among outpatients initiating antihypertensive medication in Korea: results of a retrospective claims review. Clin Ther 2009; 31: 1309-1320.
106. Zhou BF, Stamler J, Dennis B, Moag-Stahlberg A, Okuda N, Robertson C, Zhao L, Chan Q, Elliott P. Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study. J Hum Hypertens 2003; 17: 623-630.
107. Wang JG, Zeng WF, He YS, Chen LL, Wei M, Li ZP, Zhang BW, Li Y. Valsartan/ amlodipine compared to nifedipine GITS in patients with hypertension inadequately controlled by monotherapy. Adv Ther 2013; 30: 771-783.
108. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009; 338: b1665.
109. Zhao X, Li S, Ba S, He F, Li N, Ke L, Li X, Lam C, Yan LL, Zhou Y, Wu Y. Prevalence, awareness, treatment, and control of hypertension among herdsmen living at 4,300 m in Tibet. Am J Hypertens 2012; 25: 583-589.
110. Li H, Meng Q, Sun X, Salter A, Briggs NE, Hiller JE. Prevalence, awareness, treatment, and control of hypertension in rural China: results from Shandong Province. J Hypertens 2010; 28: 432-438.
111. Tian S, Dong GH, Wang D, Liu MM, Lin Q, Meng XJ, Xu LX, Hou H, Ren YF. Factors associated with prevalence, awareness, treatment and control of hypertension in urban adults from 33 communities in China: the CHPSNE Study. Hypertens Res 2011; 34: 1087-1092.
112. Sun Z, Zheng L, Detrano R, Zhang X, Xu C, Li J, Hu D, Sun Y. Incidence and predictors of hypertension among rural Chinese adults: results from Liaoning province. Ann Fam Med 2010; 8: 19-24.
113. Dong GH, Sun ZQ, Zhang XZ, Li JJ, Zheng LQ, Li J, Hu DY, Sun YX. Prevalence, awareness, treatment & control of hypertension in rural Liaoning province, China. Indian J Med Res 2008; 128: 122-127.
114. Hatori N, Sato K, Miyakawa M, Mitani K, Miyajima M, Yuasa S, Furuki T, Matsuba I, Naka K. The current status of blood pressure control among patients with hypertension: a survey of actual clinical practice. J Nippon Med Sch 2012; 79: 69-78.
115. Wang JG, Li Y. Characteristics of hypertension in Chinese and their relevance for the choice of antihypertensive drugs. Diabetes Metab Res Rev 2012; 28: 67-72.
116. Jonas JB, Nangia V, Matin A, Joshi PP, Ughade SN. Prevalence, awareness, control, and associations of arterial hypertension in a rural central India population: the Central India Eye and Medical Study. Am J Hypertens 2010; 23: 347-350.
117. Taylor EN, Hu FB, Curhan GC. Antihypertensive medications and the risk of incident type 2 diabetes. Diabetes Care 2006; 29: 1063-1070.
118. Aronow WS, Fleg JL, Pepine CJ, Artinian NT, Bakris G, Brown AS, Ferdinand KC, Ann FM, Frishman WH, Jaigobin C, Kostis JB, Mancia G, Oparil S, Ortiz E, Reisin E, Rich MW, Schocken DD, Weber MA, Wesley DJ. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus documents developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension. J Am Coll Cardiol 2011 57: 2037-2114.
119. Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T. Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study. QJM 2013; 106: 909-914.
120. Franklin SS. Elderly hypertensives: how are they different? J Clin Hypertens (Greenwich) 2012; 14: 779-786.
121. Prisant LM (ed). Hypertension in the Elderly. Humana Press: Totowa, NJ, USA, 2005.
122. Aung MN, Lorga T, Srikrajang J, Promtingkran N, Kreuangchai S, Tonpanya W, Vivarakanon P, Jaiin P, Praipaksin N, Payaprom A. Assessing awareness and knowledge of hypertension in an at-risk population in the Karen ethnic rural community, Thasongyang, Thailand. Int J Gen Med 2012; 5: 553-561.
123. Park YH, Kim H, Jang SN, Koh CK. Predictors of adherence to medication in older Korean patients with hypertension. Eur J Cardiovasc Nurs 2013; 12: 17-24.
124. Almas A, Godil SS, Lalani S, Samani ZA, Khan AH. Good knowledge about hypertension is linked to better control of hypertension; a multicentre cross sectional study in Karachi, Pakistan. BMC Res Notes 2012; 5: 579.
125. Kario K, Robbins J, Jeffers BW. Titration of amlodipine to higher doses: a comparison of Asian and Western experience. Vasc Health Risk Manag 2013; 9: 695-701.
126. Kagiyama S, Takata Y, Ansai T, Matsumura K, Soh I, Awano S, Sonoki K, Yoshida A, Torisu T, Hamasaki T, Nakamichi I, Takehara T, Iida M. Does decreased diastolic blood pressure associate with increased mortality in 80-year-old Japanese? Clin Exp Hypertens 2009; 31: 639-647.
127. Chongsuvivatwong V, Phua KH, Yap MT, Pocock NS, Hashim JH, Chhem R, Wilopo SA, Lopez AD. Health and health-care systems in southeast Asia: diversity and transitions. Lancet 2011; 377: 429-437.
128. Pongwecharak J, Treeranurat T. Lifestyle changes for prehypertension with other cardiovascular risk factors: findings from Thailand. J Am Pharm Assoc (2003) 2011; 51: 719-726.
129. Mendis S, Johnston SC, Fan W, Oladapo O, Cameron A, Faramawi MF. Cardiovascular risk management and its impact on hypertension control in primary care in lowresource settings: a cluster-randomized trial. Bull World Health Organ 2010; 88: 412-429.
130. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Roccella EJ, Levy D. Differential control of systolic and diastolic blood pressure: factors associated with lack of blood pressure control in the community. Hypertension 2000; 36: 594-599.
131. Williams B. Evolution of hypertensive disease: a revolution in guidelines. Lancet 2006; 368: 6-8.
132. Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 2001; 103: 987-992.
133. Briet M, Schiffrin EL. Treatment of arterial remodeling in essential hypertension. Curr Hypertens Rep 2013; 15: 3-9.
134. Laurent S, Schlaich M, Esler M. New drugs, procedures, and devices for hypertension. Lancet 2012; 380: 591-600.
135. Segura J, Salazar J, Ruilope LM. Dual neurohormonal intervention in CV disease: angiotensin receptor and neprilysin inhibition. Expert Opin Investig Drugs 2013; 22: 915-925.
136. Paulis L, Steckelings UM, Unger T. Key advances in antihypertensive treatment. Nat Rev Cardiol 2012; 9: 276-285.