Elderly Hypertensives: How Are They Different?

Journal of Clinical Hypertension

Volumn 14, Issue 11, 2012, Pages 779-786

  Franklin, Stanley S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; PLACEBO;

AGED; ANTIHYPERTENSIVE THERAPY; ARTERIAL STIFFNESS; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE VARIABILITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CHRONIC KIDNEY DISEASE; CLINICAL FEATURE; CORONARY ARTERY ATHEROSCLEROSIS; DEMENTIA; DIASTOLIC BLOOD PRESSURE; DRUG TREATMENT FAILURE; ESSENTIAL HYPERTENSION; GERIATRIC PATIENT; GROUPS BY AGE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE RELAXATION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; J CURVE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRACTICE GUIDELINE; PREDICTION; PRESSORECEPTOR REFLEX; PREVALENCE; PRIORITY JOURNAL; PSEUDOHYPERTENSION; PULSE PRESSURE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION;

AGED; CORONARY DISEASE; HUMANS; HYPERTENSION; MICROCIRCULATION; PRESSORECEPTORS; PREVALENCE; PULSATILE FLOW; VASCULAR RESISTANCE; VASCULAR STIFFNESS;

EID: 84868580027     PISSN: 15246175     EISSN: 17517176     Source Type: Journal    
DOI: 10.1111/j.1751-7176.2012.00703.x     Document Type: Review

References (41)

1. Burt VL, Whelton P, Roccella EJ, et al. Prevalence of hypertension in the US adult population: results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension. 1995;25:305-313.
2. Franklin SS. Aging and hypertension: the assessment of blood pressure indices in predicting coronary heart disease. J Hypertens. 1999;17:S29-S32.
3. Franklin SS, Jacobs MJ, Wong ND, et al. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives. Hypertension. 2001;37:869-874.
4. Vasan RS, Beiser A, Seshadri S, et al. Residual lifetime risk for developing hypertension in middle-aged women and women: the Framingham Heart Study. JAMA. 2002;287:1003-1010.
5. Franklin SS, Pio JR, Wong ND, et al. Predictors of new-onset diastolic and systolic hypertension. The Framingham Heart Study. Circulation. 2005;111:1121-1127.
6. Martyn CN, Greenwald SE. Impaired synthesis of elastin in walls of aorta and large conduit arteries during early development as an initiating event in pathogenesis of systemic hypertension. Lancet. 1997;350:953-955.
7. Senzai H, Iwamoto Y, Ishido H, et al. Ventricular-vascular stiffening in patients with repaired coarctation of aorta. Integrated pathophysiology of hypertension. Circulation. 2008;1(suppl 1):S191-S198.
8. Ronnback M, Fagerudd J, Forsblom C, et al. Altered age-relatedblood pressure pattern in type 1 diabetes. Circulation. 2004;110:1076-1108.
9. Cheng L-T, Gao Y-L, Gu Y, et al. Stepwise increase in the prevalence of isolated systolic hypertension with the stages of chronic kidney disease. Nephrol Dial Transplant. 2008;23:3895-3900.
10. Schulz E, Arfai K, Liu X, et al. Aortic calcification and the risk of osteroporosis and fractures. J Clin Endocrinol Metab. 2004;89:4246-4253.
11. McEniery CM, McDonnell BJ, So A, et al. Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals. Hypertension. 2009;53:524-531.
12. Franklin SS, Gustin W, Wong ND, et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation. 1997;96:308-315.
13. Franklin SS, Khan SA, Wong ND, et al. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study. Circulation. 1999;100:354-360.
14. Kass DA, Bronzwaer JGF, Paulus WJ. What mechanisms underlie diastolic dysfunction in heart failure. Cir Res. 2004;94:1533-1542.
15. Muntner P, Shimbo D, Tonelli M, et al. The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population. Findings from NHANES III, 1988 to 1994. Hypertension. 2011;57:150-166.
16. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375:938-948.
17. Bjorklund K, Lind L, Zethelius B, et al. Prognostic significance of 24-h ambulatory blood pressure characteristics for cardiovascular morbidity in a population of elderly men. J Hypertens. 2004;22:1691-1697.
18. Staessen JA, Thijs L, O'Brien ET, et al. For the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Ambulatory pulse pressure as predictor of outcome in older patients with systolic hypertension. Am J Hypertens. 2002;1(Pt 1):835-843.
19. Franklin SS, Thijs L, Hansen TW, et al. Significance of white-coat hypertension inolder persons with isolated systolic hypertension: a meta-analysis using the International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes population. Hypertension. 2012;59:564-571.
20. Verdecchia P, Angeli A, Mazzotta G, et al. Home blood pressure measurements will or will not replace 24-hour ambulatory blood pressure measurements. Hypertension. 2009;54:188-195.
21. Myers MG, Godwin M, Dawes M, et al. Measurement of blood pressure in the office: recognizing the problem and proposing the solution. Hypertension. 2010;55:195-200.
22. Mitchell GF. Arterial stiffness and wave reflection: biomarkers of cardiovascular risk. Artery Res. 2009;3:56-64.
23. Franklin SS, Wilkinson IB, McEniery CM. Unusual hypertensive phenotypes: what is their significance? Hypertension. 2012;59:173-178.
24. Smulyan H, Safar ME. Blood pressure measurements: retrospective and prospective views. Am J Hypertens. 2011;22:628-634.
25. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolate systolic hypertension: final results of the systolic hypertension in the elderly program (SHEP). JAMA. 1991;265:3255-3264.
26. Staessen JA, Fagard R, Thijs L, et al. Subgroup and per-protocol analysis of randomized European Trial on Isolated Systolic Hypertension in the Elderly. Arch Intern Med. 1998;158:1681-1691.
27. Liu L. Wang JG, Gong l, et al. Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension, Systolic Hypertension in China (SYST-CHINA) Collaborative Group. J Hypertens. 1998;16:1823-1829.
28. Beckett NS, Peters R, Fletcher AE, et al. Treatment of hypertension in patients 80years of age or older. N Engl J Med. 2008;358:1887-1898.
29. Aronow WS, Feig JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2011;57:2037-2114.
30. Franklin SS. Isolated systolic hypertension and the J-curve of cardiovascular disease risk. Artery Res. 2010;4:1-6.
31. Franklin SS, Lopez VA, Wong ND, et al. Single versus combined blood pressure components and risk for cardiovascular disease: the Framingham Heart Study. Circulation. 2009;119:243-250.
32. Franklin SS, Chow VH, Mori A, et al. The significance of low DBP in US adults with isolated systolic hypertension. J Hypertens. 2011;29:1101-1108.
33. Marschner IC, Simes RJ, Keech A. Biases in the identification of risk factors thresholds and J-curves. Am J Epidemiol. 2007;166:824-831.
34. Klassen PS, Lowrie EG, Reddan DN, et al. Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis. JAMA. 2002;287:1548-1555.
35. Messerli FH, Mancia G, Conti CR, et al. Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous? Ann Intern Med. 2006;144:884-993.
36. Messerli FH, Panjrath GS. The J-curve between blood pressure and coronary artery disease or essential hypertension. J Am Coll Cardiol. 2009;54:1827-1834.
37. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995;92:657-661.
38. Wang JG, Staessen JA, Franklin SS, et al. Systolic and diastolic blood pressure lowering as determinants of cardiovascular outcome. Hypertension. 2005;45:907-913.
39. Boshuizen HC, Izaks GJ, van Buuren S, et al. Blood pressure and mortality in elderly people aged 85 and older: community based study. BMJ. 1998;316:1780-1784.
40. Satish S, Zhang DD, Goodwin JS. Clinical significance of falling blood pressure among older adults. J Clin Epidemiol. 2001;54:961-967.
41. Protogerou AD, Safar ME, Iaria P, et al. Diastolic blood pressure and mortality in the elderly with cardiovascular disease. Hypertension. 2007;50:172-180.