Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

Clinical Infectious Diseases

Volumn 60, Issue 8, 2015, Pages 1199-1207

  Walker, Martin ^a   Specht, Sabine ^b   Churcher, Thomas S ^a   Hoerauf, Achim ^b   Taylor, Mark J ^c   Basáñez, María Gloria ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

clinical trials; doxycycline; efficacy; macrofilaricide; onchocerciasis

Indexed keywords

DOXYCYCLINE; PLACEBO; ANTHELMINTIC AGENT;

ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; HUMAN; META ANALYSIS; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REINFECTION; WOLBACHIA; ANIMAL; CLINICAL TRIAL (TOPIC); DRUG EFFECTS; FEMALE; MICROBIOLOGY; ONCHOCERCIASIS, OCULAR; STATISTICAL MODEL; TREATMENT OUTCOME;

ANIMALS; ANTHELMINTICS; CLINICAL TRIALS AS TOPIC; DOXYCYCLINE; FEMALE; HUMANS; MODELS, STATISTICAL; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS, OCULAR; TREATMENT OUTCOME; WOLBACHIA;

EID: 84926646741     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciu1152     Document Type: Article

References (38)

1. Taylor MJ, Bandi C, Hoerauf A. Wolbachia bacterial endosymbionts of filarial nematodes. Adv Parasitol 2005; 60:245-84.
2. Taylor MJ, Hoerauf A, Bockarie M. Lymphatic filariasis and onchocerciasis. Lancet 2010; 376:1175-85.
3. Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A. Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo controlled trial. Lancet 2005; 365:2116-21.
4. Hoerauf A, Volkmann L, Hamelmann C, et al. Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. Lancet 2000; 355:1242-3.
5. Hoerauf A, Mand S, Adjei O, Fleischer B, Büttner DW. Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. Lancet 2001; 357:1415-6.
6. Hoerauf A. Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. Curr Opin Infect Dis 2008; 21:673-81.
7. Specht S, Hoerauf A, Adjei O, Debrah A, Büttner DW. Newly acquired Onchocerca volvulus filariae after doxycycline treatment. Parasitol Res 2009; 106:23-31.
8. Hoerauf A, Specht S, Büttner M, et al. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. Med Microbiol Immunol 2008; 197:295-311.
9. Hoerauf A, Mand S, Volkmann L, et al. Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microb Infect 2003; 5:261-73.
10. Hoerauf A, Specht S, Marfo-Debrekyei Y, et al. Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus. Parasitol Res 2009; 104:437-47.
11. Duke BO. Evidence for macrofilaricidal activity of ivermectin against female Onchocerca volvulus: further analysis of a clinical trial in the Republic of Cameroon indicating two distinct killing mechanisms. Parasitology 2005; 130:447-53.
12. Duke BOL. The population dynamics of Onchocerca volvulus in the human host. Trop Med Parasitol 1993; 44:61-8.
13. Plaisier AP, van Oortmarssen GJ, Remme J, Habbema JD. The reproductive lifespan of Onchocerca volvulus in West African savanna. Acta Trop 1991; 48:271-84.
14. Bosshardt SC, McCall JW, Coleman SU, Jones KL, Petit TA, Klei TR. Prophylactic activity of tetracycline against Brugia pahangi infection in jirds (Meriones unguiculatus). J Parasitol 1993; 79:775-7.
15. Hoerauf A, Nissen-Pahle K, Schmetz C, et al. Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J Clin Invest 1999; 103:11-8.
16. Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother 2006; 58:256-65.
17. Gelman A, Carlin JB, Stern HS, Rubin DB. Bayesian data analysis. 2nd ed. London: Chapman & Hall, 2004.
18. Roberts GO, Rosenthal JS. Examples of adaptive MCMC. J Comput Graph Stat 2009; 18:349-67.
19. Chib S, Carlin BP. On MCMC sampling in hierarchical longitudinal models. Stat Comput 1999; 9:17-26.
20. Wearing HJ, Rohani P, Keeling MJ. Appropriate models for the management of infectious diseases. PLoS Med 2005; 2:e174.
21. de Andrade AL, Zicker F, de Oliveira RM, et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 1996; 348:1407-13.
22. Xia HX, Windle HJ, Marshall DG, Smyth CJ, Keane CT, O'Morain CA. Recrudescence of Helicobacter pylori after apparently successful eradication: novel application of randomly amplified polymorphic DNA fingerprinting. Gut 1995; 37:30-4.
23. van Rie A, Warren R, Richardson M, et al. Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. New Engl J Med 1999; 341:1174-9.
24. Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg 2003; 68:133-9.
25. Norton AJ, Gower CM, Lamberton PH, et al. Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre-And post-praziquantel treatment in Tanzania. Am J Trop Med Hyg 2010; 83:951-7.
26. Basáñez M-G, Pion SDS, Boakes E, Filipe JAN, Churcher TS, Boussinesq M. Effect of single dose ivermectin on Onchocerca volvulus: a systematic review and meta-Analysis. Lancet Infect Dis 2008; 8:310-22.
27. Plaisier AP, Cao WC, van Oortmarssen GJ, Habbema JD. Efficacy of ivermectin in the treatment of Wuchereria bancrofti infection: a model-based analysis of trial results. Parasitology 1999; 119:385-94.
28. Debrah AY, Mand S, Marfo-Debrekyei Y, Larbi J, Adejei O, Hoerauf A. Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin. Filaria J 5:1.
29. Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis. Parasitology 2014; 141:119-27.
30. Mand S, Debrah AY, Klarmann U, et al. Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial. Clin Infect Dis 2012; 55:621-30.
31. Wanji S, Tendongfor N, Nji T, et al. Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon. Parasit Vectors 2009; 2:39.
32. Tamarozzi F, Tendongfor N, Enyong PA, et al. Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis. Parasit Vectors 2012; 5:53.
33. Gardon J, Gardon-Wendel N, Demanga Ngangue, Kamgno J, Chippaux JP, Boussinesq M. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Lancet 1997; 350:18-22.
34. World Health Organization. Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation. Geneva, Switzerland: WHO, 2012.
35. Basáñez M-G, Pion SD, Churcher TS, Breitling LP, Little MP, Boussinesq M. River blindness: a success story under threat?. PLoS Med 2006; 3:e371.
36. Taylor MJ, Awadzi K, Basáñez M-G, et al. Onchocerciasis control: vision for the future from a Ghanian perspective. Parasit Vectors 2009; 2:7.
37. Churcher TS, Pion SD, Osei-Atweneboana MY, et al. Identifying suboptimal responses to ivermectin in the treatment of river blindness. Proc Natl Acad Sci U S A 2009; 106:16716-21.
38. Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK. Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study. Lancet 2007; 369:2021-9.