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This is still the standard review explaining the rationale for the MDA to eliminate lymphatic filariasis
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Ottesen EA, Duke BO, Karam M, Behbehani K. Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ 1997; 75:491-503. This is still the standard review explaining the rationale for the MDA to eliminate lymphatic filariasis.
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Debrah AY, Mand S, Specht S, et al. Doxycycline reduces plasma VEGF-C/ sVEGFR-3 and improves pathology in lymphatic filariasis. PLoS Pathog 2006; 2:e92. This study shows that Wolbachia depletion is associated with a reduction in the levels of vascular endothelial growth factors essential for lymphangiogenesis, and precedes both a reduction in lymph vessel dilation and improvement of lymphatic pathology.
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This trial showed that doxycycline confers 60% macrofilaricidal activity against O. volvulus worms and renders doxycycline the first macrofilaricidal treatment besides the toxic suramin
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, vol.357
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Hoerauf, A.1
Mand, S.2
Adjei, O.3
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52
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Efficacy of five weeks doxycycline treatment on adult Onchocerca volvulus
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in press
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Hoerauf A, Marfo-Debrekyei Y, Büttner M, et al. Efficacy of five weeks doxycycline treatment on adult Onchocerca volvulus. Parasitol Res (in press).
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Parasitol Res
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Hoerauf, A.1
Marfo-Debrekyei, Y.2
Büttner, M.3
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53
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33645781305
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A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection
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Turner JD, Mand S, Debrah AY, et al. A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection. Clin Infect Dis 2006; 42:1081-1089.
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Clin Infect Dis
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Turner, J.D.1
Mand, S.2
Debrah, A.Y.3
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54
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42549101896
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Doxycycline treatment of Brugia malayi- infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment
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This study shows that after Wolbachia depletion from microfilariae by doxycycline, rapid killing of microfilariae by DEC provokes less inflammatory immune responses and less clinical adverse reactions
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Supali T, Djuardi Y, Pfarr KM, et al. Doxycycline treatment of Brugia malayi- infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment. Clin Infect Dis 2008; 46:1385-1393. This study shows that after Wolbachia depletion from microfilariae by doxycycline, rapid killing of microfilariae by DEC provokes less inflammatory immune responses and less clinical adverse reactions.
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(2008)
Clin Infect Dis
, vol.46
, pp. 1385-1393
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Supali, T.1
Djuardi, Y.2
Pfarr, K.M.3
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55
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0037388065
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Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms
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Hoerauf A, Mand S, Volkmann L, et al. Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microbes Infect 2003; 5:261-273.
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(2003)
Microbes Infect
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, pp. 261-273
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Hoerauf, A.1
Mand, S.2
Volkmann, L.3
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56
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44549085086
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Wolbachia endosymbionts: An Achilles heal of filarial nematodes
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Hoerauf A, Rao R, editors, Karger;
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Pfarr K, Hoerauf A. Wolbachia endosymbionts: an Achilles heal of filarial nematodes. In: Hoerauf A, Rao R, editors. Wolbachia: a bug's life in another bug. Karger; 2007.
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Wolbachia: A bug's life in another bug
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Pfarr, K.1
Hoerauf, A.2
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57
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57049173209
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Awadzi K. Clinical picture and outcome of serious adverse events in the treatment of onchocerciasis. Filaria J 2003; 2 Suppl 1:S6. This is a very comprehensive overview of adverse reactions by drugs tested against human onchocerciasis.
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Awadzi K. Clinical picture and outcome of serious adverse events in the treatment of onchocerciasis. Filaria J 2003; 2 Suppl 1:S6. This is a very comprehensive overview of adverse reactions by drugs tested against human onchocerciasis.
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58
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33646200878
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Detection of adult Brugia malayi filariae by ultrasonography in humans in India and Indonesia
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Mand S, Supali T, Djuardi J, et al. Detection of adult Brugia malayi filariae by ultrasonography in humans in India and Indonesia. Trop Med Int Health 2006; 11:1375-1381.
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Trop Med Int Health
, vol.11
, pp. 1375-1381
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Mand, S.1
Supali, T.2
Djuardi, J.3
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59
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0036323053
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Progression of lymphatic vessel dilatation in the presence of living adult Wuchereria bancrofti
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Dreyer G, Addiss D, Roberts J, Noroes J. Progression of lymphatic vessel dilatation in the presence of living adult Wuchereria bancrofti. Trans R Soc Trop Med Hyg 2002; 96:157-161.
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Trans R Soc Trop Med Hyg
, vol.96
, pp. 157-161
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Dreyer, G.1
Addiss, D.2
Roberts, J.3
Noroes, J.4
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60
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34249689753
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Molecular regulation of angiogenesis and lymphangiogenesis
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Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-478.
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Nat Rev Mol Cell Biol
, vol.8
, pp. 464-478
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Adams, R.H.1
Alitalo, K.2
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61
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30744477450
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Lymphangiogenesis in development and human disease
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Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature 2005; 438:946-953.
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(2005)
Nature
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, pp. 946-953
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Alitalo, K.1
Tammela, T.2
Petrova, T.V.3
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62
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36148936760
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VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes
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Halin C, Tobler NE, Vigl B, et al. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 2007; 110:3158-3167.
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Blood
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Halin, C.1
Tobler, N.E.2
Vigl, B.3
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63
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38449106376
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Debrah A, Mand S, Toliat MR, et al. Plasma vascular endothelial growth factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. Am J Trop Med Hyg 2007; 77:601-608. This study shows for the first time a highly significant genetic association of a SNP (in a gene relevant for angiogenesis) with hydrocele development.
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Debrah A, Mand S, Toliat MR, et al. Plasma vascular endothelial growth factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. Am J Trop Med Hyg 2007; 77:601-608. This study shows for the first time a highly significant genetic association of a SNP (in a gene relevant for angiogenesis) with hydrocele development.
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64
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0038096041
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Basic lymphoedema management
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New Hampshire, USA: Hollis Publishing Company;, This book is the most comprehensive clinical overview of lymphoedema and its management
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Dreyer G, Addiss D, Dreyer P, Noroes J. Basic lymphoedema management. Treatment and prevention of problems associated with lymphatic filariasis. Hollis, New Hampshire, USA: Hollis Publishing Company; 2002. This book is the most comprehensive clinical overview of lymphoedema and its management.
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(2002)
Treatment and prevention of problems associated with lymphatic filariasis. Hollis
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Dreyer, G.1
Addiss, D.2
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66
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Assessment of families for excess risk of lymphedema of the leg in a lymphatic filariasis-endemic area
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Cuenco KT, Halloran ME, Lammie PJ. Assessment of families for excess risk of lymphedema of the leg in a lymphatic filariasis-endemic area. Am J Trop Med Hyg 2004; 70:185-190.
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Am J Trop Med Hyg
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Molecular identification of Wolbachia from the filarial nematode Mansonella perstans
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Keiser PB, Coulibaly Y, Kubofcik J, et al. Molecular identification of Wolbachia from the filarial nematode Mansonella perstans. Mol Biochem Parasitol 2008; 160:123-128.
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Mol Biochem Parasitol
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Keiser, P.B.1
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68
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Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus
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Specht S, Mand S, Marfo-Debrekyei Y, et al. Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus. Parasitol Res 2008 [Epub ahead of print].
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Parasitol Res
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69
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No depletion of Wolbachia from Onchocerca volvulus after a short course of rifampin and/or azithromycin
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Richards FO Jr, Amann J, Arana B, et al. No depletion of Wolbachia from Onchocerca volvulus after a short course of rifampin and/or azithromycin. Am J Trop Med Hyg 2007; 77:878-882.
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Am J Trop Med Hyg
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Boussinesq M. Onchocerciasis control: biological research is still needed. Parasite 2008; 15:510-514.
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Parasite
, vol.15
, pp. 510-514
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Boussinesq, M.1
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The concept paper on the helminth drug initiative. Onchocerciasis/lymphatic filariasis and schistosomiasis: Opportunities and challenges for the discovery of new drugs/diagnostics
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Hudson A, Nwaka S. The concept paper on the helminth drug initiative. Onchocerciasis/lymphatic filariasis and schistosomiasis: opportunities and challenges for the discovery of new drugs/diagnostics. Expert Opin Drug Discov 2007; 2:S3-S7.
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Expert Opin Drug Discov
, vol.2
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Hudson, A.1
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