Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis

Lancet

Volumn 355, Issue 9211, 2000, Pages 1242-1243

  Hoerauf, Achim ^a   Volkmann, Lars ^a   Hamelmann, Christoph ^b   Adjei, Ohene ^c   Autenrieth, Ingo B ^d   Fleischer, Bernhard ^a   Büttner, Dietrich W ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b KUMASI CENTRE FOR COLLABORATIVE RESEARCH IN TROPICAL MEDICINE   (Ghana)

^c KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; IVERMECTIN;

ADULT; ANIMAL TISSUE; ARTICLE; BACTERIUM; BLINDNESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG TARGETING; FILARIASIS; HOMEOSTASIS; HUMAN; HUMAN TISSUE; INFERTILITY; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PLASMODIUM; PRIORITY JOURNAL; SIDE EFFECT; SYMBIOSIS; WOLBACHIA; WORM;

ONCHOCERCA VOLVULUS; WOLBACHIA;

EID: 0034621005     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)02095-X     Document Type: Article

References (5)

1. WHO. Chagas disease, leprosy, lymphatic filariasis, onchocerciasis: prospects for elimination. Geneva: WHO, TDR/Gen/97-1, 1997: 1-35.
2. Plasier A.P., Alley E.S., van Oortmarssen G.J., Boatin B.A., Habbema J.D. Required duration of combined annual invermectin treatment and vector control in the Onchocerciasis Control Programme in West Africa. Bull World Health Organ. 75:1997;237-245.
3. Hoerauf A., Nissen-Pähle K., Schmetz C.et al. Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J Clin Invest. 103:1999;11-18.
4. Taylor M., Hoerauf A. Wolbachia bacteria of filarial nematodes. Parasitol Today. 15:1999;437-442.
5. Jomaa H., Wiesner J., Sanderbrand S.et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 285:1999;1573-1576.