Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

Parasitology Research

Volumn 104, Issue 2, 2009, Pages 437-447

  Hoerauf, Achim ^a   Specht, Sabine ^a   Marfo Debrekyei, Yeboah ^b   Büttner, Marcelle ^c   Debrah, Alexander Yaw ^b   Mand, Sabine ^a   Batsa, Linda ^b   Brattig, Norbert ^c   Konadu, Peter ^d   Bandi, Claudio ^e   Fimmers, Rolf ^f   Adjei, Ohene ^d   Büttner, Dietrich W ^c  

^a UNIVERSITY OF BONN   (Germany)

^b KUMASI CENTRE FOR COLLABORATIVE RESEARCH IN TROPICAL MEDICINE   (Ghana)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^d KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^e UNIVERSITY OF MILAN   (Italy)

^f UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; IVERMECTIN;

ADULT; AGED; ARTICLE; BLOODY DIARRHEA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GHANA; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; MALE; MICROFILARIA; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRIORITY JOURNAL; TREATMENT DURATION; WOLBACHIA;

ADOLESCENT; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; DOXYCYCLINE; FEMALE; FILARICIDES; GHANA; HUMANS; MALE; MIDDLE AGED; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; SKIN; SURVIVAL ANALYSIS; WOLBACHIA; YOUNG ADULT;

ENDOBACTERIA; ONCHOCERCA VOLVULUS; WOLBACHIA;

EID: 58649086081     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-008-1217-8     Document Type: Article

References (46)

1. EJ Albiez DW Büttner BO Duke 1988 Diagnosis and extirpation of nodules in human onchocerciasis Trop Med Parasitol 39 331 346
2. EJ Albiez G Walter A Kaiser P Ranque HS Newland AT White BM Greene HR Taylor DW Büttner 1988 Histological examination of onchocercomata after therapy with ivermectin Trop Med Parasitol 39 93 99
3. K Awadzi ET Addy NO Opoku A Plenge-Bönig DW Büttner 1995 The chemotherapy of onchocerciasis XX: ivermectin in combination with albendazole Trop Med Parasitol 46 213 220
4. K Awadzi M Hero NO Opoku ET Addy DW Büttner CD Ginger 1995 The chemotherapy of onchocerciasis XVIII. Aspects of treatment with suramin Trop Med Parasitol 46 19 26
5. K Awadzi SK Attah ET Addy NO Opoku BT Quartey 1999 The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients Trans R Soc Trop Med Hyg 93 189 194
6. K Awadzi SK Attah ET Addy NO Opoku BT Quartey JK Lazdins-Helds K Ahmed BA Boatin DA Boakye G Edwards 2004 Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana Ann Trop Med Parasitol 98 359 370
7. K Awadzi DA Boakye G Edwards NO Opoku SK Attah MY Osei-Atweneboana JK Lazdins-Helds AE Ardrey ET Addy BT Quartey K Ahmed BA Boatin EW Soumbey-Alley 2004 An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana Ann Trop Med Parasitol 98 231 249
8. MG Basanez SD Pion TS Churcher LP Breitling MP Little M Boussinesq 2006 River blindness: a success story under threat PLoS Med 3 e371
9. C Bazzocchi W Jamnongluk SL O'Neill TJ Anderson C Genchi C Bandi 2000 wsp gene sequences from the Wolbachia of filarial nematodes Curr Microbiol 41 96 100
10. BA Boatin FO Richards Jr 2006 Control of onchocerciasis Adv Parasitol 61 349 394
11. C Bourguinat SD Pion J Kamgno J Gardon BO Duke M Boussinesq RK Prichard 2007 Genetic selection of low lertile Onchocerca volvulus by ivermectin treatment PLoS Negl Trop Dis 1 e72
12. DW Büttner EJ Albiez J von Essen J Erichsen 1988 Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique Trop Med Parasitol 39 390 417
13. GC Coles AC Rhodes AJ Wolstenholme 2005 Rapid selection for ivermectin resistance in Haemonchus contortus Vet Parasitol 129 345 347
14. Y Dadzie M Neira D Hopkins 2003 Final report of the conference on the eradicability of onchocerciasis Filaria J 2 2
15. AY Debrah S Mand Y Marfo-Debrekyei J Larbi O Adjei A Hoerauf 2006 Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin Filaria J 5 1
16. AY Debrah S Mand S Specht Y Marfo-Debrekyei L Batsa K Pfarr J Larbi B Lawson M Taylor O Adjei A Hoerauf 2006 Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis PLoS Pathogens 2 9 e92
17. HP Duerr K Dietz DW Buttner H Schulz-Key 2001 A stochastic model for the aggregation of Onchocerca volvulus in nodules Parasitology 123 193 201
18. HP Duerr K Dietz H Schulz-Key DW Buttner M Eichner 2003 Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis Trans R Soc Trop Med Hyg 97 242 250
19. BO Duke 1991 Observations and reflections on the immature stages of Onchocerca volvulus in the human host Ann Trop Med Parasitol 85 103 110
20. BO Duke 2005 Evidence for macrofilaricidal activity of ivermectin against female Onchocerca volvulus: further analysis of a clinical trial in the Republic of Cameroon indicating two distinct killing mechanisms Parasitology 130 447 453
21. BO Duke G Zea-Flores J Castro EW Cupp B Muñoz 1991 Comparison of the effects of a single dose and of four six-monthly doses of ivermectin on adult Onchocerca volvulus Am J Trop Med Hyg 45 132 137
22. BOL Duke G Zea-Flores B Muñoz 1999 The embryogenesis of Onchocerca volvulus over the first year after a single dose of ivermectin Trop Med Parasitol 42 175 180
23. BO Duke AM Marty DL Peett J Gardo SD Pion J Kamgno M Boussinesq 2002 Neoplastic change in Onchocerca volvulus and its relation to ivermectin treatment Parasitology 125 431 444
24. M Franz 1988 The morphology of adult Onchocerca volvulus based on electron microscopy Trop Med Parasitol 39 359 366
25. J Gardon M Boussinesq J Kamgno N Gardon-Wendel N Demanga BO Duke 2002 Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial Lancet 360 203 210
26. JDF Habbema AP Plaisier GJ van Oortmarssen J Remme 1990 Prospective evaluation of onchocerciasis control strategies Acta Leiden 59 387 398
27. Hoerauf A (2008) Filariasis - new drugs and opportunities for lymphatic filariasis and onchocerciasis. Curr Opin Infect Dis 21. doi: 10.1097/QCO.0b013e328315cde7
28. Hoerauf A, Pfarr KM (2007) Wolbachia endosymbionts: an Achilles heal of filarial nematodes. In: Hoerauf A, Rao R (eds) Wolbachia: a bug's life in another bug. Karger, Basel
29. A Hoerauf L Volkmann C Hamelmann O Adjei IB Autenrieth B Fleischer DW Büttner 2000 Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis Lancet 355 1242 1243
30. A Hoerauf S Mand O Adjei B Fleischer DW Büttner 2001 Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment Lancet 357 1415 1416
31. A Hoerauf S Mand L Volkmann M Büttner Y Marfo-Debrekyei M Taylor O Adjei DW Büttner 2003 Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms Microbes Infect 5 261 273
32. A Hoerauf S Specht M Büttner K Pfarr S Mand R Fimmers Y Marfo-Debrekyei P Konadu AY Debrah C Bandi N Brattig A Albers J Larbi L Batsa O Adjei DW Büttner 2008 Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study Med Microbiol Immunol 197 295 311
33. A Jolodar P Fischer DW Büttner DJ Miller C Schmetz NW Brattig 2004 Onchocerca volvulus: expression and immunolocalization of a nematode cathepsin D-like lysosomal aspartic protease Exp Parasitol 107 145 156
34. S Kläger JA Whitworth RJ Post DC Chavasse MD Downham 1993 How long do the effects of ivermectin on adult Onchocerca volvulus persist Trop Med Parasitol 44 305 310
35. K Kutin TF Kruppa R Brenya R Garms 2004 Efficiency of Simulium sanctipauli as a vector of Onchocerca volvulus in the forest zone of Ghana Med Vet Entomol 18 167 173
36. MP Little LP Breitling MG Basanez ES Alley BA Boatin 2004 Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study Lancet 363 1514 1521
37. MY Osei-Atweneboana JK Eng DA Boakye JO Gyapong RK Prichard 2007 Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study Lancet 369 2021 2029
38. J Remme O Ba KY Dadzie M Karam 1986 A force-of-infection model for onchocerciasis and its applications in the epidemiological evaluation of the Onchocerciasis Control Programme in the Volta River basin area Bull World Health Organ 64 667 681
39. H Schulz-Key 1988 The collagenase technique: how to isolate and examine adult Onchocerca volvulus for the evaluation of drug effects Trop Med Parasitol 39 423 440
40. H Schulz-Key PT Soboslay 2000 Parasitological and epidemiological aspects of the host-parasite interaction in filariases and their relevance for intervention and control Nova Acta Leopold 313 189 204
41. MJ Taylor WH Makunde HF McGarry JD Turner S Mand A Hoerauf 2005 Macrofilaricidal activity following doxycycline treatment of Wuchereria bancrofti: a double-blind randomised controlled trial Lancet 365 2116 2121
42. MC Thomson V Obsomer J Kamgno J Gardon S Wanji I Takougang P Enyong JH Remme DH Molyneux M Boussinesq 2004 Mapping the distribution of Loa loa in Cameroon in support of the African Programme for Onchocerciasis Control Filaria J 3 7
43. WHO (1995a) Drugs used in parasitic diseases, 2nd edn. WHO, Geneva
44. WHO 1995 Onchocerciasis and its control WHO Tech Rep Ser 852 1 103
45. WHO 2007 Meeting of the international task force for disease eradication-11 January 2007 Wkly Epidemiol Rec 82 197 208
46. G Wildenburg K Henkle-Dührsen 1999 Onchocerca volvulus: immunolocalization of the extracellular CuZn superoxide dismutase using antibodies raised against a 15-mer epitope of this enzyme Exp Parasitol 91 1 6