Anti-Wolbachia drug discovery and development: Safe macrofilaricides for onchocerciasis and lymphatic filariasis

Parasitology

Volumn 141, Issue 1, 2014, Pages 119-127

  Taylor, Mark J ^a   Hoerauf, Achim ^b   Townson, Simon ^c   Slatko, Barton E ^d   Ward, Stephen A ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d NEW ENGLAND BIOLABS   (United States)

Author keywords

drug discovery; lymphatic filariasis; macrofilaricide; onchocerciasis; Wolbachia

Indexed keywords

ANTIBIOTIC AGENT; IVERMECTIN; MACROFILARICIDE; UNCLASSIFIED DRUG; ANTIFILARIAL AGENT; ANTIINFECTIVE AGENT; DOXYCYCLINE;

ANTIBIOTIC THERAPY; ARTICLE; AUTOPHAGY; BACTERICIDAL ACTIVITY; CELL ASSAY; DRUG ADMINISTRATION; DRUG COST; DRUG SAFETY; DRUG USE; ESSENTIAL GENE; GENOMICS; HIGH THROUGHPUT SCREENING; HUMAN; LOIASIS; LYMPHATIC FILARIASIS; MASS DRUG ADMINISTRATION; MATHEMATICAL MODEL; METABOLISM; MIXED INFECTION; MOLECULAR LIBRARY; ONCHOCERCIASIS; PREGNANCY; PRIORITY JOURNAL; SYMBIOSIS; TREATMENT DURATION; WOLBACHIA; ANIMAL; BRUGIA MALAYI; CHILD; DRUG DEVELOPMENT; DRUG EFFECTS; ELEPHANTIASIS, FILARIAL; FEMALE; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGY; ONCHOCERCA VOLVULUS; PARASITOLOGY; PHYSIOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; BRUGIA MALAYI; CHILD; DOXYCYCLINE; DRUG DISCOVERY; ELEPHANTIASIS, FILARIAL; FEMALE; FILARICIDES; HUMANS; IVERMECTIN; LOIASIS; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PREGNANCY; SYMBIOSIS; WOLBACHIA;

EID: 84891846369     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182013001108     Document Type: Article

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