Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood

Xenotransplantation

Volumn 22, Issue 2, 2015, Pages 102-111

  Harris, Donald G ^a   Quinn, Kevin J ^a   French, Beth M ^a   Schwartz, Evan ^a   Kang, Elizabeth ^a   Dahi, Siamak ^a   Phelps, Carol J ^b   Ayares, David L ^b   Burdorf, Lars ^a   Azimzadeh, Agnes M ^a   Pierson, Richard N ^a,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b REVIVICOR INC   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

ex vivo lung perfusion; genetically engineered pig; immune response; lung xenotransplantation; thromboregulation

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; DNA MODIFICATION; EX VIVO STUDY; EXPERIMENTAL PIG; GENE EXPRESSION; GENOTYPE; HUMAN; HUMAN CELL; LUNG PERFUSION; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; SAMPLE SIZE; THROMBOCYTE ACTIVATION; XENOGRAFT; XENOTRANSPLANTATION; ADVERSE EFFECTS; ANIMAL; BLOOD; DEFICIENCY; GENE INACTIVATION; GENETICS; GRAFT SURVIVAL; IMMUNOLOGY; IN VITRO STUDY; META ANALYSIS; PERFUSION; PIG; PROCEDURES; TRANSGENIC ANIMAL;

ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; CD46 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; GALACTOSYLTRANSFERASE; HEME OXYGENASE 1; HETEROPHILE ANTIGEN; HMOX1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MEMBRANE COFACTOR PROTEIN; PROCR PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD; ANTIGENS, CD46; ANTIGENS, HETEROPHILE; BLOOD; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; GRAFT SURVIVAL; HEME OXYGENASE-1; HETEROGRAFTS; HUMANS; IN VITRO TECHNIQUES; LUNG TRANSPLANTATION; PERFUSION; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 84926528240     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12149     Document Type: Article

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