Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation

Journal of Heart and Lung Transplantation

Volumn 32, Issue 11, 2013, Pages 1123-1130

  Westall, Glen P ^a   Levvey, Browyn J ^a   Salvaris, Evelyn ^b   Gooi, Julian ^a   Marasco, Sylvana ^a   Rosenfeldt, Frank ^a   Egan, Chris ^a   McEgan, Robin ^a   Mennen, Mark ^a   Russell, Prue ^b   Robson, Simon C ^c   Nottle, Mark B ^d   Dwyer, Karen M ^b   Snell, Greg I ^a   Cowan, Peter J ^b  

^a ALFRED HOSPITAL   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

ex vivo lung perfusion; Gal knockout; genetically engineered; hyperacute rejection; lung; swine; xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CD59 ANTIGEN; DECAY ACCELERATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; BLOOD CLOTTING DISORDER; COMPLEMENT ACTIVATION; CONTROLLED STUDY; EX VIVO STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNOCKOUT GENE; LUNG EDEMA; LUNG HEMORRHAGE; LUNG PERFUSION; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; LYMPHOCYTE; MACROPHAGE; MONOCYTE; NEUTROPHIL; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOSIS; TRANSGENIC PIG; XENOTRANSPLANTATION;

EX VIVO LUNG PERFUSION; GAL KNOCKOUT; GENETICALLY ENGINEERED; HYPERACUTE REJECTION; LUNG; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD; ANTIGENS, CD55; ANTIGENS, CD59; APYRASE; FEMALE; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; HUMANS; LUNG; LUNG TRANSPLANTATION; MALE; MODELS, ANIMAL; PERFUSION; SWINE; TRANSPLANTATION, HETEROLOGOUS; VASCULAR RESISTANCE;

EID: 84885960092     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2013.07.001     Document Type: Article

References (23)

1. P.J. Cowan, and A.J. d'Apice Complement activation and coagulation in xenotransplantation Immunol Cell Biol 87 2009 203 208
2. K.M. Dwyer, S.C. Robson, and H. Nandurkar Thromboregulatory manifestations in human CD39 transgenic animals, implications for thrombotic disease J Clin Invest 133 2004 1440 1446
3. R.N. Pierson, W. Kasperkonig, and D.N. Tew Hyperacute lung rejection in a pig-to-human transplant model - the role of anti-pig antibody and complement Transplantation 63 1997 94 603
4. C. Schroeder, J.S. Allan, and B.N. Nguyen Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood Transplant Proc 37 2005 512 513
5. M.B. Nottle, L.F. Beebe, and S.J. Harrison Production of homozygous α1,3 galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer Xenotransplantation 14 2007 339 344
6. P.J. Cowan, A. Aminian, and H. Barlow Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons Transplantation 69 2000 2504 2515
7. S. Steen, Q. Liao, and P.N. Wierup Transplantation of lungs from a non-heart-beating donors after functional assessment ex vivo Ann Thorac Surg 76 2003 244 252
8. P. Wierup, A. Haraldson, and F. Nilsson Ex vivo evaluation of nonacceptable donor lungs Ann Thorac Surg 81 2006 460 466
9. G.I. Snell, T. Oto, and B. Levvey Evaluation of techniques for lung transplantation following donation after cardiac death Ann Thorac Surg 81 2006 2014 2019
10. B.N. Nguyen, A.M. Azimzadeh, and C. Schroeder Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection Xenotransplantation 18 2011 94 107
11. B.N. Nguyen, A.M. Azimzadeh, and T. Zhang Life-supporting function of genetically modified swine lungs in baboons J Thorac Cardiovasc Surg 133 2007 1354 1363
12. M. Yeatman, C.W. Daggett, and W. Parker Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplant models Transplantation 65 1998 1084 1093
13. S. Pfeiffer, G.L. Zorn 3rd, and K.S. Blair Hyperacute lung rejection in the pig-to-human model 4: evidence for complement and antibody independent mechanisms Transplantation 79 2005 662 671
14. C. Schroeder, S. Pfeiffer, and G. Wu Effect of complement fragment 1 esterase inhibition on survival of human decay-accelerating factor pig lungs perfused with human blood J Heart Lung Transplant 22 2003 1365 1375
15. K.M. Dwyer, T.B. Mysore, and S. Crikis The transgenic expression of human CD39 on murine islets inhibits clotting of human blood Transplantation 82 2006 428 432
16. S. Crikis, B. Lu, and L.M. Murray-Segal Transgenic overexpression of CD39 protects against renal ischemia-reperfusion injury and transplant vascular injury Am J Transplant 10 2010 2586 2595
17. S. Deagilo, and S.C. Robson Ectonucleotides as regulators of purinergic signalling in thrombosis, inflammation and immunity Adv Pharmacol 61 2011 301 332
18. M. Schmelzle, P.J. Cowan, and S.C. Robson Which anti-platelet therapies might be beneficial in xenotransplantation? Xenotransplantation 18 2011 79 87
19. M. Mazzucato, L. De Marco, and P. Pradella Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx Thromb Haemost 75 1996 655 660
20. B. Furie, and B.C. Furie Mechanisms of thrombus formation N Engl J Med 359 2008 938 949
21. E. Cantu, K.R. Balsara, and B. Li Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts Am J Transplant 7 2007 66 75
22. S. Steen, T. Sjoberg, and L. Pierre Transplantation of lungs from a non-heart-beating donor Lancet 357 2001 825 829
23. M. Cypel, J.C. Yeung, and M. Liu Normothermic ex vivo lung perfusion in clinical lung transplantation N Engl J Med 364 2011 1431 1440