Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model

Journal of Thoracic and Cardiovascular Surgery

Volumn 113, Issue 2, 1997, Pages 390-398

  Daggett, C W ^a   Yeatman, M ^a   Lodge, A J ^a   Chen, E P ^a   Van Trigt, P ^a   Byrne, G W ^a   Logan, J S ^a   Lawson, J H ^a   Platt, J L ^a   Davis, R D ^a   Pierson III, R N ^a   Dao Minh Nguyen, ^a   Kaiser, L R ^a   Naunheim, K ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; COMPLEMENT; DECAY ACCELERATING FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; LUNG COMPLIANCE; LUNG EDEMA; LUNG FUNCTION; LUNG INJURY; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; TRANSGENIC ANIMAL; VENOUS OXYGEN TENSION; XENOTRANSPLANTATION;

EID: 0031049033     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(97)70337-4     Document Type: Article

References (22)

1. JD Hardy WR Webb ML. Dalton Lung homotransplantation in man JAMA 186 1963 1065 1074
2. JD Cooper FG Pearson GA. Patterson Technique of successful lung transplantation in humans J Thorac Cardiovasc Surg 93 1987 173 181
3. CE Owens RW Evans NL. Acher Estimates of organ specific donor availability for the United States Transplant Proc 25 1993 1541 1542
4. S Sundaresan GD Trachiotis M Aoe Donor lung procurement: assessment and operative technique Ann Thorac Surg 56 1993 1409 1413
5. JL Platt RJ Fischel AJ Matas SA Reif RM Bolman FH. Bach Immunopathology of hyperacute xenograft rejection in a swine-to-primate model Transplantation 52 1991 214 220
6. JL Platt FH. Bach The barrier to xenotransplantation Transplantation 52 1991 937 947
7. R Pierson III W Kaspar-Konig DN Tew VK Young PC Bradley DJ White Profound pulmonary hypertension characteristic of pig lung rejection by human blood is mediated by xenoreactive antibody independent of complement Transplant Proc 27 1995 274
8. RJ Kaplon JL Platt PA Kwiatkowski NM Edwards H Xu AS Shah Absence of hyperacute rejection in pig-to-primate orthotopic pulmonary xenografts Transplantation 59 1995 410 416
9. KR McCurry DL Kooyman LE Diamond JW Byrne MJ Martin JS Logan Human complement regulatory proteins in transgenic animals regulate complement activation in xenoperfused organs Transplant Proc 27 1995 317 318
10. KD McCurry DL Kooyman CW Alvarado A Cotterell M Martin J Logan Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury Nature Med 1 1995 423 427
11. Byrne GW, McCurry KR, Martin MJ, McClellan SM, Platt JL, Logan JS. Transgenic pigs expressing human CD59 and DAF produce an intrinsic barrier to complement mediated damage. Transplantation. In press.
12. G Campbell N Crisp E. Brown Total cardiac bypass in humans utilizing a pump and heterologous lung oxygenator (dog lungs) Surgery 40 1956 364 371
13. L Bryant B Eiseman M. Avery Studies of the porcine lung as an oxygenator for human blood J Thorac Cardiovasc Surg 55 1968 255 263
14. K Katsuyuki JC Aust SD Wax WR. Webb Hemodynamic and functional changes in xenogenic, perfused, isolated lungs J Thorac Cardiovasc Surg 72 1976 115 118
15. AP. Dalmasso The complement system in xenotransplantation Immunopharmacology 24 1992 149 160
16. JC Rosenberg E Hawkins F. Rector Mechanisms of immunological injury during antibody-mediated hyperacute rejection of renal heterografts Transplantation 11 1971 151 157
17. JC Rosenberg RJ Broersma G. Bullemer Relationship of platelets, blood coagulation, and fibrinolysis to hyperacute rejection of renal xenografts Transplantation 8 1969 152 161
18. KJ Johnson PA. Ward Role of oxygen metabolites in immune complex injury of lung J Immunol 81 1981 2365 2369
19. PR Craddock J Fehr KL Brigham RS Kronenberb HS. Jacob Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis N Engl J Med 296 1977 769 774
20. JK Kirklin S Westaby EH Blackstone JW Kirklin DE Chenowith AD. Pacifico Complement and the damaging effects of cardiopulmonary bypass J Thorac Cardiovasc Surg 86 1983 845 857
21. SK Pruitt R Baldwin III H Marsh Jr SS Lin CJ Yeh R. Bollinger The effect of soluble complement receptor type 1 on hyperacute xenograft rejection Transplantation 52 1991 868 873
22. JR Leventhal AP Dalmasso JW Cromwell JL Platt CJ Manivel R Bolman III Prolongation of cardiac xenograft survival by depletion of complement Transplantation 55 1993 857 866