One-year heterotopic cardiac xenograft survival in a pig to baboon model

American Journal of Transplantation

Volumn 14, Issue 2, 2014, Pages 488-489

  Mohiuddin, M M ^a   Singh, A K ^a   Corcoran, P C ^a   Hoyt, R F ^a   Thomas III, M L ^b   Lewis, B G T ^b   Eckhaus, M ^b   Reimann, K A ^c   Klymiuk, N ^d   Wolf, E ^d   Ayares, D ^e   Horvath, K A ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

^e REVIVICOR INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BABOON; DISEASE MODEL; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGY; PATHOLOGY; PROCEDURES; SWINE; TIME; XENOGRAFT;

ANIMALS; DISEASE MODELS, ANIMAL; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; PAPIO; SWINE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84895058965     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12562     Document Type: Letter

References (5)

1. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience. Nat Med 2005; 11: 29-31.
2. Mohiuddin MM, Corcoran PC, Singh AK, et al. B-cell depletion extends the survival of GTKO hCD46Tg pig heart xenografts in baboons for up to 8 months. Am J Transplant 2012; 12: 763-771.
3. Tazelaar HD, Byrne GW, McGregor CG., Comparison of Gal and non-Gal-mediated cardiac xenograft rejection. Transplantation 2011; 91: 968-975.
4. Lin CC, Cooper DK, Dorling A., Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol 2009; 21: 75-80.
5. Mohiuddin MM, Singh AK, Corcoran PC, et al. Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model. Xenotransplantation 2013; doi: 1111/xen.12066 [Epub ahead of print].