An investigation into the role of polymeric carriers on crystal growth within amorphous solid dispersion systems

Molecular Pharmaceutics

Volumn 12, Issue 4, 2015, Pages 1180-1192

  Tian, Yiwei ^a   Jones, David S ^a   Andrews, Gavin P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

amorphous; crystal growth kinetics; felodipine; Flory Huggins; HPMCAS; nucleation and growth; PVP; Raman spectral mapping; solid dispersions; Soluplus; viscosity

Indexed keywords

FELODIPINE; POLYMER; DRUG CARRIER; GLASS; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; MACROGOL DERIVATIVE; METHYLCELLULOSE; POLY(VINYL PHENYL KETONE); POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE;

ARTICLE; CRYSTALLIZATION; DECOMPOSITION; DISPERSION; DRUG SOLUBILITY; MICROSCOPY; MISCIBILITY; PHASE SEPARATION; POLYMERIZATION; PRIORITY JOURNAL; SOLID; TEMPERATURE; VISCOSITY; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; HEAT; MEDICINAL CHEMISTRY; PROCEDURES; RAMAN SPECTROMETRY; SOLUBILITY; THERMODYNAMICS;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FELODIPINE; GLASS; HOT TEMPERATURE; METHYLCELLULOSE; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; THERMODYNAMICS; VISCOSITY;

EID: 84926505298     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500702s     Document Type: Article

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