Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model

In Vitro Cellular and Developmental Biology - Animal

Volumn 51, Issue 4, 2015, Pages 336-344

  Pradit, Waranee ^a   Chomdej, Siriwadee ^a   Nganvongpanit, Korakot ^a   Ongchai, Siriwan ^a  

^a CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Cartilage explant; Chondroprotection; Hypophyllanthin; Phyllanthin; Phyllanthus amarus

Indexed keywords

PHYLLANTHUS AMARUS; SUS;

CULTURE MEDIUM; GELATINASE A; GLYCOSAMINOGLYCAN; HYPOPHYLLANTHIN; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; LIGNAN; PHYLLANTHIN; PROTECTIVE AGENT; PROTEOGLYCAN; URONIC ACID;

ANIMAL; ARTICULAR CARTILAGE; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; MEDICINAL PLANT; METABOLISM; ORGAN CULTURE TECHNIQUE; OSTEOARTHRITIS; PHYLLANTHUS; PIG; PROCEDURES;

ANIMALS; CARTILAGE, ARTICULAR; CULTURE MEDIA; GLYCOSAMINOGLYCANS; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; LIGNANS; MATRIX METALLOPROTEINASE 2; ORGAN CULTURE TECHNIQUES; OSTEOARTHRITIS; PHYLLANTHUS; PLANTS, MEDICINAL; PROTECTIVE AGENTS; PROTEOGLYCANS; SWINE; URONIC ACIDS;

EID: 84926486295     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-014-9846-y     Document Type: Article

References (48)

1. Abramson SB, Attur M (2009) Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther 11:227
2. Alam MR, Ji JR, Kim MS, Kim NS (2011) Biomarkers for identifying the early phases of osteoarthritis secondary to medial patellar luxation in dogs. J Vet Sci 12:273–280
3. Amin ZA, Alshawsh MA, Kassim M, Ali HM, Abdulla MA (2013) Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats. BMC Complement Altern Med 13:160
4. Bjarnason I, Hayllar J, MacPherson AJ, Russell AS (1993) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104:1832–1847
5. Carvalho RS, Yen EHK, Suga DM (1995) Glycosaminoglycan synthesis in the rat articular disk in response to mechanical stress. Am J Orthod Dentofacial Orthop 107:401–410
6. Cesaretti M, Luppi E, Maccari F, Volpi N (2003) A 96-well assay for uronic acid carbazole reaction. Carbohydr Polym 54:59–61
7. Chaiwongsa R, Ongchai S, Tangyuenyong S, Kongtawelert P, Panthong A, Reutrakul R (2012) Chondroprotective potential of bioactive compounds of Zingiber cassumunar Roxb. against cytokine-induced cartilage degradation in explant culture. J Med Plants Res 6:5204–5213
8. Chiang LC, Ng LT, Cheng PW, Chiang W, Lin CC (2005) Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol 32:811–816
9. Chirdchupunseree H, Pramyothin P (2010) Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes. J Ethnopharmacol 128:172–176
10. Chotjumlong P, Khongkhunthian S, Ongchai S, Reutrakul V, Krisanaprakornkit S (2010) Human β-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts. J Periodontal Res 45:464–470
11. Crick F (1970) Central dogma of molecular biology. Nature 227:561–563
12. Del Carlo M Jr, Loeser RF (2008) Cell death in osteoarthritis. Curr Rheumatol Rep 10:37–42
13. Engel LW, Straus SE (2002) Development of therapeutics: opportunities within complementary and alternative medicine. Nat Rev Drug Discov 1:229–237
14. Fang SH, Rao YK, Tzeng YM (2008) Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol 116:333–340
15. Farndale RW, Sayers CA, Barrett AJ (1982) A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 9:247–248
16. Funk JL, Frye JB, Oyarzo JN, Timmermann BN (2009) Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. J Nat Prod 72:403–407
17. Galasso O, Familiari F, Gori MD, Gasparini G (2012) Recent findings on the role of gelatinases (matrix metalloproteinase-2 and −9) in osteoarthritis. Adv Orthop 2012:834208
18. Goldring MB (2000) The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43:1916–1926
19. Goldring MB, Otero M (2011) Inflammation in osteoarthritis. Curr Opin Rheumatol 23:471–478
20. Hashimoto M, Nakasa T, Hikata T, Asahara H (2008) Molecular network of cartilage homeostasis and osteoarthritis. Med Res Rev 28:464–481
21. Hoppmann RA, Peden JG, Ober SK (1991) Central nervous system side effects of nonsteroidal anti-inflammatory drugs: aseptic meningitis, psychosis, and cognitive dysfunction. Arch Intern Med 151:1309–1313
22. Huh JE, Baek YH, Kim YJ, Lee JD, Choi DY, Park DS (2009) Protective effects of butanol fraction from Betula platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis. J Ethnopharmacol 123:515–521
23. Jeng KC, Hou RC, Wang JC, Ping LI (2005) Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB. Immunol Lett 97:101–106
24. Kandhare AD, Ghosh P, Ghule AE, Zambare GN, Bodhankar SL (2013) Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: role of phyllanthin and hypophyllanthin. Apollo Med 10:87–97
25. Karuna R, Reddy SS, Baskar R, Saralakumari D (2009) Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. Indian J Pharmacol 41:64–67
26. Kassuya CAL, Leite DFP, Melo LV, Rehder VLG, Calixto JB (2005) Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. Planta Med 71:721–726
27. Kiemer AK, Hartung T, Huber C, Vollmar AM (2003) Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway. J Hepatol 38:289–297
28. Krithika R, Jyothilakshmi V, Verma RJ (2014) Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/NF-kappaB and pro-fibrotic factor TGF-beta1 mediated inflammatory signaling. Toxicol Ind Health. (in press). doi: 10.1177/0748233714532996
29. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V (2009) Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med 15:891–897
30. Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64:1697–1170
31. Lotz M, Hashimoto S, Kuhn K (1999) Mechanisms of chondrocyte apoptosis. Osteoarthritis Cartil 7:389–391
32. Lu KH, Yang HW, Su CW, Lue KH, Yang SF, Hsieh YS (2013) Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. Food Chem Toxicol 52:193–199
33. Mali SM, Sinnathambi A, Kapase CU, Bodhankar SL, Mahadik KR (2011) Anti-arthritic activity of standardised extract of Phyllanthus amarus in Freund’s complete adjuvant induced arthritis. Biomed Aging Pathol 1:185–190
34. Martel-Pelletier J, Pelletier JP (2010) Effects of diacerein at the molecular level in the osteoarthritis disease process. Ther Adv Musculoskelet Dis 2:95–104
35. Mueller MB, Tuan RS (2011) Anabolic/Catabolic balance in pathogenesis of osteoarthritis: identifying molecular targets. PM&R 3:S3–S11
36. Ong-Chai S, Chaiwongsa R, Viriyakhasem N, Pompimon W, Tangyuenyong S (2008) Effect of active compounds from Andrographis paniculata (nees) on protection of equine articular cartilage degradation in vitro. KKU Vet J 18:81–96
37. Parhamifar L, Andersen H, Moghimi SM (2013) Lactate dehydrogenase assay for assessment of polycation cytotoxicity. Methods Mol Biol 948:13–22
38. Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK (2011) Phyllanthus amarus:Ethnomedicinal uses, phytochemistry and pharmacology:A review. J Ethnopharmacol 138:286–313
39. Phitak T, Pothacharoen P, Settakorn J, Poompimol W, Caterson B, Kongtawelert P (2012) Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry 80:77–88
40. Pradit W, Nganvongpanit K, Siengdee P, Buddhachat K, Osathanunkul M, Chomdej S (2012) In vitro effects of polysaccharide gel extracted from durian rinds (Durio Zibethinus L.) on the enzymatic activities of MMP-2, MMP-3 and MMP-9 in canine chondrocyte culture. IJBBB 2:151–154
41. Tang YQ, Jaganath I, Manikam R, Sekaran SD (2013) Phyllanthus suppresses prostate cancer cell, PC-3, proliferation and induces apoptosis through multiple signalling pathways (MAPKs, PI3K/Akt, NFB, and Hypoxia). Evid Based Complement Alternat Med 2013:13
42. Tripathi AK, Verma RK, Gupta AK, Gupta MM, Khanuja SPS (2006) Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography. Phytochem Analysis 17:394–397
43. Troeberg L, Nagase H (2012) Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta 1824:133–145
44. Weis M, Heeschen C, Glassford AJ, Cooke JP (2002) Statins have biphasic effects on angiogenesis. Circulation 105:739–745
45. Woolf AD (2012) Influential global alliance calls on governments and the World Health Organisation to prioritise musculoskeletal health following findings of Global Burden of Disease Study 2010. Truro, UK. http://www.cmcc.ca/document.doc?id=1459. Cited 10 Aug 2014
46. Yahayo W, Supabphol A, Supabphol R (2013) Suppression of human fibrosarcoma cell metastasis by Phyllanthus emblica extract in vitro. Asian Pac J Cancer Prev 14:6863–6867
47. Zamli Z, Adams MA, Tarlton JF, Sharif M (2013) Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease. Int J Mol Sci 14:17729–17743
48. Zrimšek P, Kos VK, Mrkun J, Kosec M (2007) Diagnostic value of MMP-2 and MMP-9 in synovial fluid for identifying osteoarthritis in the distal interphalangeal joint in horses. Acta Veterinaria Brno 76:87–95