Mechanisms of chondrocyte apoptosis

Osteoarthritis and Cartilage

Volumn 7, Issue 4, 1999, Pages 389-391

  Lotz, M ^a   Hashimoto, S ^a   Kuhn K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Chondrocytes; Nitric oxide

Indexed keywords

CALCIUM; FAS ANTIGEN; INTERLEUKIN 1; NITRIC OXIDE; PROTEOGLYCAN; PYROPHOSPHATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; APOPTOSIS; ARTHRITIS; CALCIFICATION; CARTILAGE CELL; CARTILAGE DEGENERATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MONONUCLEAR PHAGOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RABBIT;

EID: 0033166579     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1998.0220     Document Type: Conference Paper

References (14)

1. Ishizaki Y, Burne JF, Raff MC. Autocrine signals enable chondrocytes to survive in culture. J Cell Biol 1994;126:1069-77.
2. Meredith JE Jr, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993;4:953-61.
3. Yang C, Li SW, Helminen HJ, Khillan JS, Bao Y, Prockop DJ. Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp Cell Res 1997;235:370-3.
4. Hashimoto S, Setareh M, Ochs RL, Lotz M. Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 1997;40:1749-55.
5. Kim YM, de Vera ME, Watkins SC, Billiar TR. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 1997:272:1402-11.
6. Blanco FJ, Ochs RL, ScHwarz H, Lotz M. Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 1995;146:75-85.
7. Clancy RM, Abramson SB, Kohne C, Rediske J. Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury. J Cell Physiol 1997;172:183-91.
8. Frenkel SR, Clancy RM, Ricci JL, Di Cesare PE, Rediske JJ, Abramson SB. Effects of nitric oxide on chondrocyte migration, adhesion, and cytoskeletal assembly. Arthritis Rheum 1996;39:1905-12.
9. Clancy RM, Rediske J, Tang JX, Nijher N, Frenkel S, Philips M, Abramson SB. Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. J Clin Invest 1997;100:1789-96.
10. Hashimoto S, Ochs RL, Komiya S, Lotz M. The linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 1998;41: 1632-8.
11. Hashimoto S, Takahashi, Amiel D, Coutts RD, Lotz M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 1998;41:1266-74.
12. Anderson HC. Electron microscopic studies of induced cartilage development and calcification. J Cell Biol 1967;35:81-101.
13. Bonucci E. Fine structure of early cartilage calcification. J Ultrastruct Res 1967;20:33-50.
14. Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, Lotz M. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci USA 1998;95:3094-9.