Human β-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts

Journal of Periodontal Research

Volumn 45, Issue 4, 2010, Pages 464-470

  Chotjumlong, P ^a   Khongkhunthian, S ^a   Ongchai, S ^b   Reutrakul, V ^c   Krisanaprakornkit, Suttichai ^a  

^a CHIANG MAI UNIVERSITY   (Thailand)

^b Faculty of Medicine Chiang Mai University   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Gene regulation; Human defensin; Inflammation; Lipid mediator

Indexed keywords

AUTACOID; BETA DEFENSIN; BETA DEFENSIN 3, HUMAN; BETA-DEFENSIN 3, HUMAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEFB1 PROTEIN, HUMAN; DEFB4A PROTEIN, HUMAN; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PROSTAGLANDIN E2; PTGS1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; SULFONAMIDE;

ARTICLE; CELL CULTURE; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FIBROBLAST; GINGIVA; HUMAN; METABOLISM; TIME; UPREGULATION;

BETA-DEFENSINS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GINGIVA; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; NITROBENZENES; SULFONAMIDES; TIME FACTORS; UP-REGULATION;

EID: 77954859999     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2009.01259.x     Document Type: Article

References (38)

1. Abiko Y, Saitoh M, Nishimura M, Yamazaki M, Sawamura D, Kaku T. Role of beta-defensins in oral epithelial health and disease. Med Mol Morphol 2007, 40:179-184.
2. Guthmiller JM, Vargas KG, Srikantha R. Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother 2001, 45:3216-3219.
3. Maisetta G, Batoni G, Esin S. Activity of human beta-defensin 3 alone or combined with other antimicrobial agents against oral bacteria. Antimicrob Agents Chemother 2003, 47:3349-3351.
4. Mineshiba F, Takashiba S, Mineshiba J, Matsuura K, Kokeguchi S, Murayama Y. Antibacterial activity of synthetic human β-defensin-2 against periodontal bacteria. J Int Acad Periodontol 2003, 5:35-40.
5. Joly S, Maze C, McCray PB, Guthmiller JM. Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol 2004, 42:1024-1029.
6. Vardar-Sengul S, Demirci T, Sen BH, Erkizan V, Kurulgan E, Baylas H. Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases. J Periodontal Res 2007, 42:429-437.
7. Yang D, Chertov O, Bykovskaia SN. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999, 286:525-528.
8. Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur J Immunol 2001, 31:1066-1075.
9. Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H. The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes. J Immunol 2005, 175:1776-1784.
10. Niyonsaba F, Ushio H, Nakano N. Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 2007, 127:594-604.
11. Yin L, Dale BA. Activation of protective responses in oral epithelial cells by Fusobacterium nucleatum and human beta-defensin-2. J Med Microbiol 2007, 56:976-987.
12. Nishimura M, Abiko Y, Kurashige Y. Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines. J Dermatol Sci 2004, 36:87-95.
13. Mendieta CF, Reeve CM, Romero JC. Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. J Periodontol 1985, 56:44-47.
14. ElAttar TM. Prostaglandin E2 in human gingiva in health and disease and its stimulation by female sex steroids. Prostaglandins 1976, 11:331-341.
15. Offenbacher S, Odle BM, Van Dyke TE. The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. J Periodontal Res 1986, 21:101-112.
16. Tsai CC, Hong YC, Chen CC, Wu YM. Measurement of prostaglandin E2 and leukotriene B4 in the gingival crevicular fluid. J Dent 1998, 26:97-103.
17. Noguchi K, Shitashige M, Ishikawa I. Involvement of cyclooxygenase-2 in interleukin-1alpha-induced prostaglandin production by human periodontal ligament cells. J Periodontol 1999, 70:902-908.
18. Bando Y, Noguchi K, Kobayashi H, Yoshida N, Ishikawa I, Izumi Y. Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells. J Periodontal Res 2009, 44:395-401.
19. Yucel-Lindberg T, Ahola H, Nilsson S, Carlstedt-Duke J, Modeer T. Interleukin-1 beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts. Inflammation 1995, 19:549-560.
20. Offenbacher S, Heasman PA, Collins JG. Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J Periodontol 1993, 64:432-444.
21. Zhang F, Engebretson SP, Morton RS. The overexpression of cyclo-oxygenase-2 in chronic periodontitis. J Am Dent Assoc 2003, 134:861-867.
22. Kardesler L, Buduneli N, Biyikoglu B, Cetinkalp S, Kutukculer N. Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease. Clin Biochem 2008, 41:863-868.
23. Weinberg A, Krisanaprakornkit S, Dale BA. Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med 1998, 9:399-414.
24. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000, 68:2907-2915.
25. Krisanaprakornkit S, Chotjumlong P, Kongtawelert P, Reutrakul V. Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2. Int Immunol 2008, 20:21-29.
26. Krisanaprakornkit S, Kimball JR, Dale BA. Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family. J Immunol 2002, 168:316-324.
27. Yucel-Lindberg T, Ahola H, Carlstedt-Duke J, Modeer T. Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor. Biochem Biophys Res Commun 1999, 257:528-532.
28. Noguchi K, Iwasaki K, Shitashige M, Endo H, Kondo H, Ishikawa I. Cyclooxygenase-2-dependent prostaglandin E2 down-regulates intercellular adhesion molecule-1 expression via EP2/EP4 receptors in interleukin-1beta-stimulated human gingival fibroblasts. J Dent Res 2000, 79:1955-1961.
29. Taylor K, Barran PE, Dorin JR. Structure-activity relationships in beta-defensin peptides. Biopolymers 2008, 90:1-7.
30. N'Guessan PD, Hippenstiel S, Etouem MO. Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 2006, 290:L1131-L1138.
31. Nakao S, Ogata Y, Shimizu-Sasaki E, Yamazaki M, Furuyama S, Sugiya H. Activation of NFkappaB is necessary for IL-1beta-induced cyclooxygenase-2 (COX-2) expression in human gingival fibroblasts. Mol Cell Biochem 2000, 209:113-118.
32. Liu AY, Destoumieux D, Wong AV. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 2002, 118:275-281.
33. Kisich KO, Carspecken CW, Fieve S, Boguniewicz M, Leung DY. Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. J Allergy Clin Immunol 2008, 122:62-68.
34. Tao R, Jurevic RJ, Coulton KK. Salivary antimicrobial peptide expression and dental caries experience in children. Antimicrob Agents Chemother 2005, 49:3883-3888.
35. Smith HS. Arachidonic acid pathways in nociception. J Support Oncol 2006, 4:277-287.
36. Lu Q, Samaranayake LP, Darveau RP, Jin L. Expression of human beta-defensin-3 in gingival epithelia. J Periodontal Res 2005, 40:474-481.
37. Noguchi T, Shiba H, Komatsuzawa H. Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Inflammation 2003, 27:341-349.
38. Baroni A, Donnarumma G, Paoletti I. Antimicrobial human beta-defensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells. Peptides 2009, 30:267-272.