Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways

Food and Chemical Toxicology

Volumn 52, Issue , 2013, Pages 193-199

  Lu, Ko Hsiu ^a,b   Yang, Hui Wen ^a,b   Su, Chun Wen ^b   Lue, Ko Huang ^b   Yang, Shun Fa ^a,b   Hsieh, Yih Shou ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Migration; Osteosarcoma; Phyllanthus urinaria; U PA

Indexed keywords

GELATINASE A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHYLLANTHUS URINARIA EXTRACT; PLANT EXTRACT; PROTEIN KINASE B; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; METASTASIS INHIBITION; OSTEOSARCOMA; OSTEOSARCOMA CELL; PHYLLANTHUS; PHYLLANTHUS URINARIA; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; WOUND CLOSURE; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; OSTEOSARCOMA; PHOSPHORYLATION; PHYLLANTHUS; PLANT EXTRACTS; PLANTS, MEDICINAL; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

PHYLLANTHUS URINARIA;

EID: 84871418838     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.11.019     Document Type: Article

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