Codelivery of small molecule hedgehog inhibitor and miRNA for treating pancreatic cancer

Molecular Pharmaceutics

Volumn 12, Issue 4, 2015, Pages 1289-1298

  Kumar, Virender ^a   Mondal, Goutam ^a   Slavik, Paige ^a   Rachagani, Satyanarayna ^b   Batra, Surinder K ^b   Mahato, Ram I ^a  

^a Departments of Pharmaceutical Sciences   (India)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

GDC 0449; Hh signaling; K RAS; micelles; miR let7b; pancreatic ductal adenocarcinoma

Indexed keywords

COPOLYMER; LET7B; MACROGOL DERIVATIVE; MICRORNA; POLY(ETHYLENE GLYCOL) BLOCK POLY( 2 METHYL 2 CARBOXYLPROPYLENECARBONATE GRAFT DODECANOL GRAFT TETRAETHYLENEPENTAMINE); UNCLASSIFIED DRUG; VISMODEGIB; ALKENE; ANILIDE; CARBONIC ACID DERIVATIVE; CATION; DRUG CARRIER; ETHYLENEDIAMINE DERIVATIVE; LAURYL ALCOHOL; MICELLE; POLYMER; PROPYLENE; PYRIDINE DERIVATIVE; SONIC HEDGEHOG PROTEIN; TETRAETHYLENEPENTAMINE;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL PROLIFERATION; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROPHOBICITY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; MOUSE; NONHUMAN; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; POLYMERIZATION; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH; TUMOR VOLUME; ADENOCARCINOMA; ANIMAL; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; DISEASE COURSE; ENDOSOME; METABOLISM; NUDE MOUSE; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUNEL ASSAY;

ADENOCARCINOMA; ALKENES; ANILIDES; ANIMALS; CARBONATES; CATIONS; CELL LINE, TUMOR; CELL SURVIVAL; DISEASE PROGRESSION; DODECANOL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOSOMES; ETHYLENEDIAMINES; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, NUDE; MICELLES; MICRORNAS; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS; POLYMERS; PYRIDINES; SIGNAL TRANSDUCTION;

EID: 84926483088     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500847s     Document Type: Article

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