Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic Hedgehog pathways

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Huang, Minzhao ^a   Tang, Su Ni ^a   Upadhyay, Ghanshyam ^a   Marsh, Justin L ^b   Jackman, Christopher P ^b   Shankar, Sharmila ^a   Srivastava, Rakesh K ^a  

^a UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLINE; CYCLOOXYGENASE 2; DEATH RECEPTOR 4; DEATH RECEPTOR 5; EMBELIN; GELATINASE A; GELATINASE B; INTERLEUKIN 8; K RAS PROTEIN; KI 67 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; BENZOQUINONE DERIVATIVE; KRAS PROTEIN, HUMAN; KRAS2 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN P21; RAS PROTEIN; SHH PROTEIN, HUMAN; SHH PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL CYCLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; METASTASIS INHIBITION; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; DRUG EFFECTS; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; METASTASIS; MUTANT MOUSE STRAIN; NEOVASCULARIZATION, PATHOLOGIC; NUDE MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BENZOQUINONES; CELL LINE, TUMOR; HEDGEHOG PROTEINS; HETEROGRAFTS; HUMANS; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898833828     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092161     Document Type: Article

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