Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1

AIDS

Volumn 29, Issue 5, 2015, Pages 519-530

  Ruffin, Nicolas ^a,b,c   Brezar, Vedran ^a,b,c   Ayinde, Diana ^d   Lefebvre, Cécile ^a,b,c   Wiesch, Julian Schulze Zur ^e,g   Van Lunzen, Jan ^e,g   Bockhorn, Maximilian ^e   Schwartz, Olivier ^d   Hocini, Hakim ^a,b,c   Lelievre, Jean Daniel ^a,b,c   Banchereau, Jacques ^a,b,c,f   Levy, Yves ^a,b,c   Seddiki, Nabila ^a,b,c  

^a HENRI MONDOR HOSPITAL   (France)

^b FACULTÉ DE MÉDECINE   (France)

^c Vaccine Research Institute   (France)

^d INSTITUT PASTEUR   (France)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f JACKSON LABORATORY   (United States)

^g LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

HIV restriction; HIV 1; lymphocyte activation; SAMHD1; T helper 17 cells

Indexed keywords

HYDROLASE; KI 67 ANTIGEN; SAMHD1 ENZYME; UNCLASSIFIED DRUG; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SAMHD1 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; INFECTION SENSITIVITY; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH17 CELL; ADOLESCENT; ADULT; AGED; BIOSYNTHESIS; BLOOD; CELL PROLIFERATION; CHILD; FEMALE; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPH NODE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHYSIOLOGY; VIROLOGY; VIRUS REPLICATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BLOOD; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHILD; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HIV-1; HUMANS; IMMUNOPHENOTYPING; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; VIRUS REPLICATION; YOUNG ADULT;

EID: 84926465830     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000594     Document Type: Article

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