Tracing the evolution of angucyclinone monooxygenases: Structural determinants for C-12b hydroxylation and substrate inhibition in PgaE

Biochemistry

Volumn 52, Issue 26, 2013, Pages 4507-4516

  Kallio, Pauli ^a   Patrikainen, Pekka ^a   Belogurov, Georgiy A ^a   Mäntsälä, Pekka ^a   Yang, Keqian ^b   Niemi, Jarmo ^a   Metsä Ketelä, Mikko ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRANCHING POINTS; DIMER INTERFACE; KINETIC CHARACTERIZATION; NON-CONSERVED RESIDUES; POLYKETIDE ANTIBIOTICS; SECONDARY STRUCTURES; STRUCTURAL DETERMINANTS; SUBSTRATE INHIBITION;

BINDING ENERGY; BIOCHEMISTRY; CRYSTAL STRUCTURE; ENZYME KINETICS; KETONES; REACTION INTERMEDIATES; SUBSTRATES;

HYDROXYLATION;

CARBON; GLUCOSE REGULATED PROTEIN 78; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CRYSTAL STRUCTURE; DEHYDRATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HYDROXYLATION; MOLECULAR EVOLUTION; PRIORITY JOURNAL;

ANTHRAQUINONES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; HYDROXYLATION; MIXED FUNCTION OXYGENASES; MUTAGENESIS; POLYGALACTURONASE; PROTEIN CONFORMATION; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84880164381     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400381s     Document Type: Article

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