Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase

Nature

Volumn 422, Issue 6928, 2003, Pages 185-189

  Ose, Toyoyuki ^a   Watanabe, Kenji ^a   Mie, Takashi ^a   Honma, Mamoru ^a   Watanabe, Hiromi ^a   Yao, Min ^a   Oikawa, Hideaki ^a   Tanaka, Isao ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYMES; HYDROGEN BONDS; HYDROPHOBICITY; METABOLITES; SUBSTRATES;

DIELS-ALDER REACTIONS;

OLEFINS;

FUNGAL ENZYME; MACROPHOMATE SYNTHASE; PYRUVIC ACID; UNCLASSIFIED DRUG;

MEDICINE;

ARTICLE; BINDING KINETICS; CHEMICAL BOND; CRYSTAL STRUCTURE; CYCLOADDITION; DIELS ALDER REACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROPHOBICITY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ALCOHOLS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; ELECTROSTATICS; FUNGI; HYDROGEN BONDING; HYDROPHOBICITY; MAGNESIUM; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PROTEIN CONFORMATION; PYRONES; PYRUVIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

BETULACEAE;

EID: 0037434992     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01454     Document Type: Article

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