Silibinin alleviates hyperlipidaemia, restores mucin content, modulates TGF-β and fosters apoptosis in experimental rat colon carcinogenesis

Journal of Functional Foods

Volumn 11, Issue C, 2014, Pages 472-481

  Nagarajan, Sangeetha ^a,b   Namasivayam, Nalini ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b SASTRA UNIVERSITY   (India)

Author keywords

AgNOR; Bax Bcl2 ratio; Caspases; Colon cancer; Lipid profile; Mucin

Indexed keywords

RATTUS;

EID: 84926340518     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2014.10.025     Document Type: Article

References (43)

1. Agarwal B., Rao C.V., Bhendwal S., Ramey W.R., Shirin H., Reddy B.S., Holt P.R. Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac. Gastroenterology 1999, 117:838-847.
2. Aranganathan S., Nalini N. Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer. Phytotherapy Research 2013, 7:999-1005.
3. Barton T.P., Cruse J.P., Lewin M.R. Changes in serum lipids related to the presence of experimental colon cancer. British Journal of Cancer 1987, 4:451-454.
4. Biasi F., Vizio B., Mascia C., Gaia E., Zarkovic N., Chiarpotto E., Leonarduzzi G., Poli G. c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. Free Radical Biology and Medicine 2006, 41:443-454.
5. Bruce W.R., Wolever T.M., Giacca A. Mechanisms linking diet and colorectal cancer: The possible role of insulin resistance. Nutrition and Cancer 2000, 37:19-26.
6. Corsetti G., Pasini E., Assanelli D., Bianchi R. Effects of acute caffeine administration on NOS and Bax/Bcl2 expression in the myocardium of rat. Pharmacological Research 2008, 57:19-25.
7. Day S.D., Enos R.T., McClellan J.L., Steiner J.L., Velázquez K.T., Murphy E.A. Linking inflammation to tumourigenesis in a mouse model of high-fat-diet-enhanced colon cancer. Cytokine 2013, 64:454-462.
8. Derynck R., Akhurst R.J., Balmain A. TGF-beta signaling in tumour suppression and cancer progression. Nature Genetics 2001, 29:117-129.
9. Endo H., Hosono K., Fujisawa T., Takahashi H., Sugiyama M., Yoneda K., Nozaki Y., Fujita K., Yoneda M., Inamori M., Wada K., Nakagama H., Nakajima A. Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions. Gut 2009, 58:1637-1643.
10. Falholt K., Lund B., Falholt W. An easy colorimetric micromethod for routine determination of free fatty acids in plasma. Clinica Chimica Acta 1973, 46:105-111.
11. Femia A.P., Tarquini E., Salvadori M., Ferri S., Giannini A., Dolara P., Caderni G. K-ras mutations and mucin profile in preneoplastic lesions and colon tumours induced in rats by 1,2-dimethylhydrazine. International Journal of Cancer 2008, 122:117-123.
12. Ferlay J., Parkin D.M., Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. European Journal of Cancer 2010, 46:765-781.
13. Foster L.B., Dunn R.T. Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clinical Chemistry 1973, 19:338-340.
14. Francis J.M., Heyworth C.M., Spooncer E., Pierce A., Dexter T.M., Whetton A.D. Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells. The Journal of Biological Chemistry 2000, 275:39137-39145.
15. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 1972, 18:499-502.
16. Gordon K.J., Blobe G.C. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Biochimica et Biophysica Acta 2008, 4:197-228.
17. Igney F.H., Krammer P.H. Death and anti-death: Tumour resistance to apoptosis. Nature Reviews. Cancer 2002, 2:277-288.
18. Izzo C., Grillo F., Murador E. Improved method for determination of high-density-lipoprotein cholesterol I. Isolation of high-density lipoproteins by use of polyethylene glycol 6000. Clinical Chemistry 1981, 27:371-374.
19. Koh T.J., Bulitta C.J., Fleming J.V., Dockray G.J., Varro A., Wang T.C. Gastrin is a target of the β-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. The Journal of Clinical Investigation 2000, 106:533-539.
20. Lee J.H., Wan X.H., Song J., Kang J.J., Chung W.S., Lee E.H., Kim E.K. TGF-beta-induced apoptosis and reduction of Bcl-2 in human lens epithelial cells in vitro. Current Eye Research 2002, 5:147-153.
21. Loguercio C., Festi D. Silybin and the liver: From basic research to clinical practice. World Journal of Gastroenterology 2011, 17:2288-2301.
22. McKeown-Eyssen G. Epidemiology of colorectal cancer revisited: Are serum triglycerides and/or plasma glucose associated with risk?. Cancer Epidemiology, Biomarkers & Prevention 1994, 8:87-95.
23. Mohandas K.M. Colorectal cancer in India: Controversies, enigmas and primary prevention. Indian Journal of Gastroenterology 2011, 30:3-6.
24. Nalini N., Aranganathan S., Kabalimurthy J. Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Toxicology Mechanisms and Methods 2012, 22:397-408.
25. Niho N., Takahashi M., Kitamura T., Shoji Y., Itoh M., Noda T., Sugimura T., Wakabayashi K. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Research 2003, 18:6090-6095.
26. Padidar S., Farquharson A.J., Williams L.M., Kearney R., Arthur J.R., Drew J.E. High-fat diet alters gene expression in the liver and colon: Links to increased development of aberrant crypt foci. Digestive Diseases and Sciences 2012, 57:1866-1874.
27. Ploton D., Menager M., Jeannesson P. Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer regions at the optical level. The Histochemical Journal 1986, 18:5-14.
28. Ramasamy K., Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Letters 2008, 269:352-362.
29. Rao C.V., Simi B., Wynn T.T., Garr K., Reddy B.S. Modulating effects of amount and types of dietary fat on colonic mucosal phospholipase A2 phosphatidylinosital-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumour promotion in male F344 rats. Cancer Research 1996, 56:532-537.
30. Rashmi R., Kumar S., Karunagaran D. Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. Carcinogenesis 2004, 25:1867-1877.
31. Ravichandran K., Velmurugan B., Gu M., Singh R.P., Agarwal R. Inhibitory effect of silibinin against azoxymethane-induced colon tumourigenesis in A/J mice. Clinical Cancer Research 2010, 18:4595-4606.
32. Reddy B.S. Dietary fat and colon cancer: Animal model studies. Lipids 1992, 10:807-813.
33. Reddy B.S., Watanabe K., Weisburger J.H. Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea. Cancer Research 1977, 11:4156-4159.
34. Rocher A.E., Blanco A.M., Palaoro L.A. Usefulness of AgNOR technique in the interpretation of serous effusions. Revista médica de Chile 2000, 9:963-968.
35. Salim E.I., Abou-Shafey A.E., Masoud A.A., Elgendy S.A. Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay-Implications for its mechanism of action. Asian Pacific Journal of Cancer Prevention 2011, 12:2385-2392.
36. Sangeetha N., Aranganathan S., Nalini N. Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer. Investigational New Drugs 2010, 28:225-233.
37. Sangeetha N., Aranganathan S., Panneerselvam J., Shanthi P., Rama G., Nalini N. Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model. European Journal of Pharmacology 2010, 643:93-100.
38. Sangeetha N., Felix A.J., Nalini N. Silibinin modulates biotransforming microbial enzymes and prevents 1, 2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer. European Journal of Cancer Prevention 2009, 18:385-394.
39. Sangeetha N., Viswanathan P., Balasubramanian T., Nalini N. Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats. European Journal of Pharmacology 2012, 674:430-438.
40. Siegel P.M., Shu W., Cardiff R.D., Muller W.J., Massagué J. Transforming growth factor beta signaling impairs Neu-induced mammary tumourigenesis while promoting pulmonary metastasis. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:8430-8435.
41. Yang W., Chang Y., Huang H., Wang Y., Yu X. Association between obesity, serum lipids, and colorectal polyps in old Chinese people. Gastroenterology Research and Practice 2013, 2013:931084.
42. Zhang F., Du G. Dysregulated lipid metabolism in cancer. World Journal of Biological Chemistry 2012, 8:167-174.
43. Zlatkis A., Zak B., Boyle A.J. A new method for the direct determination of serum cholesterol. Journal of Laboratory and Clinical Medicine 1953, 41:486-492.