A genetic variant of PPARA modulates cardiovascular risk biomarkers after milk consumption

Nutrition

Volumn 30, Issue 10, 2014, Pages 1144-1150

  Loria Kohen, Viviana ^a   Espinosa Salinas, Isabel ^a   Ramirez de Molina, Ana ^a   Casas Agustench, Patricia ^a,b   Herranz, Jesús ^a   Molina, Susana ^a   Fonollá, Juristo ^c   Olivares, Mónica ^c   Lara Villoslada, Federico ^d   Reglero, Guillermo ^a,e   Ordovas, Jose M ^a,b  

^a IMDEA FOOD INSTITUTE   (Spain)

^b TUFTS UNIVERSITY   (United States)

^c Biosearch Life SA   (Spain)

^d Puleva Biotech SA   (Spain)

^e INSTITUTE OF FOOD SCIENCE RESEARCH CIAL   (Spain)

Author keywords

Lipid profile; Milk; Nutrigenetics; PPARA; Rs135549

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SATURATED FATTY ACID; CHOLESTEROL; FAT INTAKE; FATTY ACID;

ADULT; AGED; ARTICLE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIETARY REFERENCE INTAKE; FEMALE; FOOD INTAKE; GENE DIET INTERACTION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HIGH RISK PATIENT; HUMAN; LIPID METABOLISM; MALE; MILK; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ADVERSE EFFECTS; ANIMAL; BLOOD; CARDIOVASCULAR DISEASES; CHEMISTRY; FAT INTAKE; GENETICS; METABOLISM; MIDDLE AGED;

ADULT; AGED; ANIMALS; CARDIOVASCULAR DISEASES; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY FATS; FATTY ACIDS; FEMALE; GENOTYPE; HUMANS; LIPID METABOLISM; MALE; MIDDLE AGED; MILK; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR ALPHA;

EID: 84926256958     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2014.02.012     Document Type: Article

References (45)

1. Smith S.C. Screening for high-risk cardiovascular disease: a challenge for the guidelines: Comment on "systematic review of guidelines on cardiovascular risk assessment: Which recommendations should clinicians follow for a cardiovascular health check?". Arch Intern Med 2010, 170:40-42.
2. Mensink R.P., Katan M.B. Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 1992, 12:911-919.
3. Gordon T. The diet-heart idea: outline of a history. Am J Epidemiol 1988, 127:220-225.
4. Diet, nutrition and prevention of chronic diseases. Technical report series no. 916 2003, WHO Study Group, World Health Organization, Geneva, Switzerland.
5. Lichtenstein A.H., Appel L.J., Brands M., Carnethon M., Daniels S., Franch H.A., et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006, 114:82-96. American Heart Association Nutrition Committee.
6. Graham I., Atar D., Borch-Johnsen K., Boysen G., Burell G., Cifkova R., et al. European guidelines on cardiovascular disease prevention in clinical practice: Executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts). Eur Heart J 2007, 28:2375-2414.
7. Hu F.B., Stampfer M.J., Manson J.E., Ascherio A., Colditz G.A., Speizer F.E., et al. Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 1999, 70:1001-1008.
8. Patterson E., Larsson S.C., Wolk A., Akesson A. Association between dairy food consumption and risk of myocardial infarction in women differs by type of dairy food. J Nutr 2013, 14:74-79.
9. Kliem K.E., Givens D.I. Dairy products in the food chain: their impact on health. Annu Rev Food Sci Technol 2011, 2:21-36.
10. Larsson S.C., Virtamo J., Wolk A. Dairy consumption and risk of stroke in Swedish women and men. Stroke 2012, 43:1775-1780.
11. Lamarche B. Review of the effect of dairy products on non-lipid risk factors for cardiovascular disease. J Am Coll Nutr 2008, 27:741S-746S.
12. German J.B., Gibson R.A., Krauss R.M., Nestel P., Lamarche B., van Staveren, et al. A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. Eur J Nutr 2009, 48:191-203.
13. Huth P.J., Park K.M. Influence of dairy product and milk fat consumption oncardiovascular disease risk: a review of the evidence. Adv Nutr 2012, 3:266-285.
14. Soedamah-Muthu S.S., Masset G., Verberne L., Geleijnse J.M., Brunner E.J. Consumption of dairy products and associations with incident diabetes, CHD and mortality in the Whitehall II study. Br J Nutr 2012, 7:1-9.
15. Elwood P.C., Pickering J.E., Givens D.I., Gallacher J.E. The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: an overview of the evidence. Lipids 2010, 45:925-939.
16. Corella D., Arregui M., Coltell O., Portolés O., Guillem-Sáiz P., Carrasco P., et al. Association of the LCT-13910 C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population. Obesity (Silver Spring) 2011, 19:1707-1714.
17. van Staveren W.A., Steijns J.M., de Groot L.C. Dairy products as essential contributors of (micro-) nutrients in reference food patterns: an outline for elderly people. J Am Coll Nutr 2008, 27:747S-754S.
18. German J.B., Dillard C.J. Composition, structure and absorption of milk lipids: a source of energy, fat-soluble nutrients and bioactive molecules. Crit Rev Food Sci Nutr 2006, 46:57-92.
19. Contarini G., Povolo M. Phospholipids in milk fat: composition, biological and technological significance, and analytical strategies. Int J Mol Sci 2013, 14:2808-2831.
20. Corella D., Ordovas J.M. Nutrigenomics in cardiovascular medicine. Circ Cardiovasc Genet 2009, 2:637-651.
21. Simopoulos A.P. Nutrigenetics/nutrigenomics. Annu Rev Public Health 2010, 31:53-68.
22. Bouchard C., Ordovas J.M. Fundamentals of nutrigenetics and nutrigenomics. Prog Mol Biol Transl Sci 2012, 108:1-15.
23. Zeisel S.H., Waterland R.A., Ordovás J.M., Muoio D.M., Jia W., Fodor A. Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research. JPEN J Parenter Enteral Nutr 2013, 37:190-200.
24. Fonollá J., López-Huertas E., Machado F.J., Molina D., Alvarez I., Mármol E., et al. Milk enriched with "healthy fatty acids" improves cardiovascular risk markers and nutritional status in human volunteers. Nutrition 2009, 25:408-414.
25. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
26. Manninen V., Tenkanen L., Koskinen P., Huttunen J.K., Mänttäri M., Heinonen O.P., et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in theHelsinki Heart Study. Implications for treatment. Circulation 1992, 85:37-45.
27. Cullen P., Schulte H., Assmann G. The Munster Heart Study (PROCAM) Total Mortality in Middle-Aged Men is increased at low total and LDL cholesterol concentrations in smokers but not in nonsmokers. Circulation 1997, 6:2128-2136.
28. Kannel W.B. Risk stratification of dyslipidemia: insights from the Framingham Study. Curr Med Chem Cardiovasc Hematol Agents 2005, 3:187-193.
29. Millán J., Pintó X., Muñoz A., Zúñiga M., Rubiés-Prat J., Pallardo L.F., et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag 2009, 5:757-765.
30. de Bakker P.I., Yelensky R., Pe'er I., Gabriel S.B., Daly M.J., Altshuler D. Efficiency and power in genetic association studies. Nat Genet 2005, 37:1217-1223.
31. Tholstrup T., Sandström B., Hermansen J.E., Hølmer G. Effect of modified dairy fat on postprandial and fasting plasma lipids and lipoproteins in healthy young men. Lipids 1998, 33:11-21.
32. Jacques H., Gascon A., Arul J., Boudreau A., Lavigne C., Bergeron J. Modified milk fat reduces plasma triacylglycerol concentrations in normolipidemic men compared with regular milk fat and nonhydrogenated margarine. Am J Clin Nutr 1999, 70:983-991.
33. Soedamah-Muthu S.S., Ding E.L., Al-Delaimy W.K., Hu F.B., Engberink M.F., Willett W.C., et al. Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 2011, 93:158-171.
34. van Aerde M.A., Soedamah-Muthu S.S., Geleijnse J.M., Snijder M.B., Nijpels G., Stehouwer C.D., et al. Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: The Hoorn Study. Eur J Nutr 2013, 52:609-616.
35. Garcia-Rios A., Pérez-Martinez P., Delgado-Lista J., Lopez-Miranda J., Perez-Jimenez F. Nutrigenetics of the lipoprotein metabolism. Mol Nutr Food Res 2012, 56:171-183.
36. Ordovas J.M., Lopez-Miranda J., Mata P., Perez-Jimenez F., Lichtenstein A.H., Schaefer E.J. Gene-diet interaction in determining plasma lipid response to dietary intervention. Atherosclerosis 1995, 118(Suppl):S11-S27.
37. Ohlsson L. Dairy products and plasma cholesterol levels. Food Nutr Res 2010, 54.
38. Ordovas J.M. The genetics of serum lipid responsiveness to dietary interventions. Proc Nutr Soc 1999, 58:171-187.
39. Tai E.S., Demissie S., Cupples L.A., Corella D., Wilson P.W., Schaefer E.J., et al. Association between the PPARA L162 V polymorphism and plasma lipid levels: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 2002, 22:805-810.
40. Hamblin M., Chang L., Fan Y., Zhang J., Chen Y.E. PPARs and the cardiovascular system. Antioxid Redox Signal 2009, 11:1415-1452.
41. Paradis A.M., Fontaine-Bisson B., Bossé Y., Robitaille J., Lemieux S., Jacques H., et al. The peroxisome proliferator-activated receptor alpha Leu162 Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men. Am J Clin Nutr 2005, 81:523-530.
42. Tanaka T., Ordovas J.M., Delgado-Lista J., Perez-Jimenez F., Marin C., Perez-Martinez P., et al. Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men. J Lipid Res 2007, 48:1402-1408.
43. Estévez-González M.D., Saavedra-Santana P., López-Ríos L., Chirino R., Cebrero-García E., Pena-Quintana L., et al. HDL cholesterol levels in children with mild hypercholesterolemia: effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1 B polymorphism in the CETP gene. Ann Nutr Metab 2010, 56:288-293.
44. Varela-Moreiras G., Avila J.M., Cuadrado C., del Pozo S., Ruiz E., Moreiras O. Evaluation of food consumption and dietary patterns in Spain by the Food Consumption Survey: updated information. Eur J Clin Nutr 2010, 64:S37-S43.
45. Mosca L., Benjamin E.J., Berra K., Bezanson J.L., Dolor R.J., Lloyd-Jones D.M., et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update: a guideline from the American Heart Association. Circulation 2011, 123:1243-1262.