Highlights of the 2012 research workshop: Using nutrigenomics and metabolomics in clinical nutrition research

Journal of Parenteral and Enteral Nutrition

Volumn 37, Issue 2, 2013, Pages 190-200

  Zeisel, Steven H ^a   Waterland, Robert A ^b   Ordovás, José M ^c   Muoio, Deborah M ^d   Jia, Wei ^e   Fodor, Anthony ^f  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c TUFTS UNIVERSITY   (United States)

^d DUKE UNIVERSITY   (United States)

^e UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^f UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

intervention; metabolomics; nutrigenetics

Indexed keywords

CARNITINE;

CARDIOVASCULAR RISK; CLINICAL PRACTICE; CONFERENCE PAPER; DIABETES MELLITUS; EPIGENETICS; FOOD INTAKE; GENE EXPRESSION; GENETIC VARIABILITY; HEART DISEASE; HUMAN; INSULIN RESISTANCE; METABOLISM; METABOLOMICS; MICROBIAL COMMUNITY; NUTRIGENOMICS; NUTRITION; PRIORITY JOURNAL; WORKSHOP;

ANIMALS; BIOMEDICAL RESEARCH; CONGRESSES AS TOPIC; EPIGENOMICS; FEMALE; HUMANS; MALE; METABOLOMICS; NUTRIGENOMICS; NUTRITION THERAPY; NUTRITIONAL SCIENCES;

EID: 84873681265     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607112462401     Document Type: Conference Paper

References (63)

1. Zeisel SH. Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am J Clin Nutr. 2007 ; 86 (3). 542-548 (Pubitemid 47435818)
2. Zeisel SH. Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr. 2009 ; 89 (5). 1488S - 1493S
3. Zeisel SH. Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models. Brain Res. 2008 ; 1237: 5-11
4. German JB, Hammock BD, Watkins SM. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics. 2005 ; 1 (1). 3-9
5. A haplotype map of the human genome. Nature. 2005 ; 437 (7063). 1299-1320
6. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007 ; 8 (4). 253-262 (Pubitemid 46439287)
7. Fischer LM, daCosta K, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007 ; 85 (5). 1275-1285 (Pubitemid 46740469)
8. Resseguie M, Song J, Niculescu MD, da Costa KA, Randall TA, Zeisel SH. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J. 2007 ; 21 (10). 2622-2632 (Pubitemid 47230690)
9. da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J. 2006 ; 20 (9). 1336-1344 (Pubitemid 44943841)
10. Kohlmeier M, da Costa KA, Fischer LM, Zeisel SH. Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A. 2005 ; 102 (44). 16025-16030 (Pubitemid 41552861)
11. Resseguie ME, da Costa KA, Galanko JA, Patel M, Davis IJ, Zeisel SH. Aberrant estrogen regulation of PEMT results in choline deficiency- associated liver dysfunction. J Biol Chem. 2011 ; 286 (2). 1649-1658
12. Sha W, da Costa KA, Fischer LM, et al. Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J. 2010 ; 24 (8). 2962-2975
13. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003 ; 33: 245-254 (Pubitemid 36278835)
14. Gluckman PD, Hanson MA, Buklijas T, Low FM, Beedle AS. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol. 2009 ; 5 (7). 401-408
15. Waterland RA, Garza C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr. 1999 ; 69 (2). 179-197 (Pubitemid 29065538)
16. Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007 ; 27: 363-388 (Pubitemid 351373362)
17. Rakyan VK, Blewitt ME, Druker R, Preis JI, Whitelaw E. Metastable epialleles in mammals. Trends Genet. 2002 ; 18 (7). 348-351 (Pubitemid 34804446)
18. Dolinoy DC, Huang D, Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A. 2007 ; 104 (32). 13056-13061 (Pubitemid 351737592)
19. Waterland RA, Dolinoy DC, Lin JR, Smith CA, Shi X, Tahiliani KG. Maternal methyl supplements increase offspring DNA methylation at Axin fused. Genesis. 2006 ; 44 (9). 401-406 (Pubitemid 44454044)
20. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003 ; 23 (15). 5293-5300 (Pubitemid 36950884)
21. Wolff GL, Kodell RL, Moore SR, Cooney CA. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 1998 ; 12 (11). 949-957 (Pubitemid 28359576)
22. Yen TT, Gill AM, Frigeri LG, Barsh GS, Wolff GL. Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. FASEB J. 1994 ; 8 (8). 479-488
23. Waterland RA, Kellermayer R, Laritsky E, et al. Season of conception in rural Gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet. 2010 ; 6 (12). e1001252
24. Rayco-Solon P, Fulford AJ, Prentice AM. Differential effects of seasonality on preterm birth and intrauterine growth restriction in rural Africans. Am J Clin Nutr. 2005 ; 81 (1). 134-139 (Pubitemid 43073386)
25. Bates CJ, Prentice AM, Paul AA. Seasonal variations in vitamins A, C, riboflavin and folate intakes and status of pregnant and lactating women in a rural Gambian community: some possible implications. Eur J Clin Nutr. 1994 ; 48 (9). 660-668 (Pubitemid 24275924)
26. Schnabel RB, Baccarelli A, Lin H, Ellinor PT, Benjamin EJ. Next steps in cardiovascular disease genomic research - sequencing, epigenetics, and transcriptomics. Clin Chem. 2012 ; 58 (1). 113-126
27. Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci U S A. 2012 ; 109 (4). 1193-1198
28. Corella D, Ordovas JM. Nutrigenomics in cardiovascular medicine. Circ Cardiovasc Genet. 2009 ; 2 (6). 637-651
29. Wittwer J, Rubio-Aliaga I, Hoeft B, Bendik I, Weber P, Daniel H. Nutrigenomics in human intervention studies: current status, lessons learned and future perspectives. Mol Nutr Food Res. 2011 ; 55 (3). 341-358
30. Corella D, Arnett DK, Tsai MY, et al. The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study. Clin Chem. 2007 ; 53 (6). 1144-1152 (Pubitemid 46867533)
31. Corella D, Peloso G, Arnett DK, et al. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. Arch Intern Med. 2009 ; 169 (20). 1897-1906
32. Corella D, Tai ES, Sorli JV, et al. Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction. Int J Obes (Lond). 2011 ; 35 (5). 666-675
33. Smith CE, Ordovas JM, Sanchez-Moreno C, Lee YC, Garaulet M. Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity. Int J Obes (Lond). 2012 ; 36 (1). 130-136
34. Kanoni S, Nettleton JA, Hivert MF, et al. Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes. 2011 ; 60 (9). 2407-2416
35. Ronteltap A, van Trijp JC, Renes RJ. Consumer acceptance of nutrigenomics-based personalised nutrition. Br J Nutr. 2009 ; 101 (1). 132-144 (Pubitemid 352795592)
36. Stewart-Knox BJ, Bunting BP, Gilpin S, et al. Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers. Br J Nutr. 2009 ; 101 (7). 982-989
37. Muoio DM. Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?. Biochim Biophys Acta. 2010 ; 1801 (3). 281-288
38. Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes. 2009 ; 58 (11). 2429-2443
39. Koves TR, Li P, An J, et al. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem. 2005 ; 280 (39). 33588-33598 (Pubitemid 41397160)
40. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008 ; 7 (1). 45-56
41. Arduini A, Bonomini M, Savica V, Amato A, Zammit V. Carnitine in metabolic disease: potential for pharmacological intervention. Pharmacol Ther. 2008 ; 120 (2). 149-156
42. Makowski L, Noland RC, Koves TR, et al. Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J. 2009 ; 23 (2). 586-604
43. Noland RC, Koves TR, Seiler SE, et al. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem. 2009 ; 284 (34). 22840-22852
44. Power RA, Hulver MW, Zhang JY, et al. Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia. 2007 ; 50 (4). 824-832 (Pubitemid 46355838)
45. Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev. 1998 ; 14 (4). 263-283 (Pubitemid 29110250)
46. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med. 2000 ; 342 (5). 301-307 (Pubitemid 30075242)
47. Murao S, Makino H, Kaino Y, et al. Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients. Diabetes. 2004 ; 53 (10). 2684-2690 (Pubitemid 39299279)
48. Hanafusa T, Imagawa A. Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners. Nat Clin Pract Endocrinol Metab. 2007 ; 3 (1). 36-45 (Pubitemid 46006611)
49. Bao Y, Zhao T, Wang X, Qiu Y, Su M, Jia W. Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers. J Proteome Res. 2009 ; 8 (4). 1623-1630
50. Qiu Y, Cai G, Su M, et al. Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 ; 8 (10). 4844-4850
51. Gill SR, Pop M, DeBoy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science. 2006 ; 312 (5778). 1355-1359 (Pubitemid 43839542)
52. Possemiers S, Bolca S, Verstraete W, Heyerick A. The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals. Fitoterapia. 2011 ; 82 (1). 53-66
53. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The Human Microbiome Project. Nature. 2007 ; 449 (7164). 804-810 (Pubitemid 47598620)
54. Structure, function and diversity of the human microbiome in an adult reference population. Nature. 2012 ; 486 (7402). 207-214
55. A framework for human microbiome research. Nature. 2012 ; 486 (7402). 215-221
56. Ye Y Proceedings of the BIBM 2010. New York: Institute of Electrical and Electronics Engineers ; 2010: 153-157.
57. Fodor A, DeSantis T, Badger J, et al. The most wanted bacteria from the human microbiome. Presented at: General Meeting of the American Society for Microbiology ; San Francisco, CA ;..
58. Huse S, Ye Y, Zhou Y, Fodor AA. A core human microbiome as viewed through 16S rRNA sequences clusters. PLOS One. 2012 ; 7 (6). e34242
59. Spencer MD, Hamp TJ, Reid RW, Fischer LM, Zeisel SH, Fodor AA. association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. 2011 ; 140 (3). 976-986
60. Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011 ; 334 (6052). 105-108
61. Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011 ; 473 (7346). 174-180
62. Knights D, Parfrey Laura W, Zaneveld J, Lozupone C, Knight R. Human-associated microbial signatures: examining their predictive value. Cell Host Microbe. 2011 ; 10 (4). 292-296
63. Gloor GB, Hummelen R, Macklaim JM, et al. Microbiome profiling by Illumina sequencing of combinatorial sequence-tagged PCR products. PLoS ONE. 2010 ; 5 (10). e15406