Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity

Cell Research

Volumn 24, Issue 10, 2014, Pages 1250-1265

  Chu, Yajing ^a   Rosso, Leonardo Gómez ^a   Huang, Ping ^b   Wang, Zhichao ^a   Xu, Yichi ^b   Yao, Xiao ^a   Bao, Menghan ^a   Yan, Jun ^b   Song, Haiyun ^b   Wang, Gang ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b Chinese Academy of Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MUS;

CHOLESTEROL; DROSOPHILA PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; GLUCOSE; INSULIN; MED23 PROTEIN, MOUSE; MEDIATOR COMPLEX; RNA POLYMERASE II;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; DROSOPHILA; GENETIC TRANSCRIPTION; GENETICS; GLUCONEOGENESIS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; LARVA; LIPID METABOLISM; LIVER; LIVER CELL; MALE; METABOLISM; MOUSE; MOUSE MUTANT; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; DROSOPHILA; DROSOPHILA PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GLUCONEOGENESIS; GLUCOSE; HEPATOCYTES; INSULIN; LARVA; LIPID METABOLISM; LIVER; MALE; MEDIATOR COMPLEX; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; RNA INTERFERENCE; RNA POLYMERASE II; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84926195518     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.120     Document Type: Article

References (70)

1. Guariguata L. By the numbers: new estimates from the IDF Diabetes Atlas Update for 2012. Diabetes Res Clin Pract 2012; 98:524-525.
2. Alberti KG, Zimmet P. Epidemiology: Global burden of disease-where does diabetes mellitus fit in? Nat Rev Endocrinol 2013; 9:258-260
3. Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008; 9:193-205.
4. Lusis AJ, Attie AD, Reue K. Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet 2008; 9:819-830.
5. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414:799-806.
6. Zhao X, Feng D, Wang Q, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest 2012; 122:2417-2427.
7. Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 2007; 447:1012-1016.
8. Malik S, Roeder RG. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 2010; 11:761-772.
9. Taatjes DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci 2010; 35:315-322.
10. Conaway RC, Conaway JW. Function and regulation of the Mediator complex. Curr Opin Genet Dev 2011; 21:225-230.
11. Knuesel MT, Taatjes DJ. Mediator and post-recruitment regulation of RNA polymerase II. Transcription 2011; 2:28-31.
12. Meyer KD, Lin SC, Bernecky C, Gao Y, Taatjes DJ. p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol 2010; 17:753-760.
13. Gomes NP, Bjerke G, Llorente B, et al. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev 2006; 20:601-612.
14. Wang W, Yao X, Huang Y, et al. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. Transcription 2013; 4:39-51.
15. Mukundan B, Ansari A. Novel role for mediator complex subunit Srb5/Med18 in termination of transcription. J Biol Chem 2011; 286:37053-37057.
16. Carlsten JO, Zhu X, Gustafsson CM. The multitalented Mediator complex. Trends Biochem Sci 2013; 38:531-537
17. Takahashi H, Parmely TJ, Sato S, et al. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 2011; 146:92-104.
18. Conaway RC, Conaway JW. The Mediator complex and transcription elongation. Biochim Biophys Acta 2013; 1829:69-75.
19. Galbraith MD, Allen MA, Bensard CL, et al. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell 2013; 153:1327-1339.
20. Kagey MH, Newman JJ, Bilodeau S, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010; 467:430-435.
21. Ding N, Zhou H, Esteve PO, et al. Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell 2008; 31:347-359.
22. Huang Y, Li W, Yao X, et al. Mediator complex regulates alternative mRNA processing via the MED23 subunit. Mol Cell 2012; 45:459-469.
23. Wang W, Huang L, Huang Y, et al. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell 2009; 16:764-771.
24. Yin JW, Liang Y, Park JY, et al. Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev 2012; 26:2192-2205.
25. Stevens JL, Cantin GT, Wang G, Shevchenko A, Berk AJ. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science 2002; 296:755-758.
26. Ito M, Okano HJ, Darnell RB, Roeder RG. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J 2002; 21:3464-3475.
27. Cheng Z, White MF. Targeting forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal 2011; 14:649-661.
28. Rena G, Guo S, Cichy SC, Unterman TG, Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 1999; 274:17179-17183.
29. Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem 1999; 274:15982-15985.
30. Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 2007; 6:208-216.
31. Shin DJ, Joshi P, Hong SH, et al. Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis. Nucleic Acids Res 2012; 40:11499-11509.
32. Zhang J, Ou J, Bashmakov Y, et al. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci USA 2001; 98:3756-3761.
33. Guo S, Rena G, Cichy S, et al. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 1999; 274:17184-17192.
34. Hall RK, Yamasaki T, Kucera T, et al. Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins. J Biol Chem 2000; 275:30169-30175.
35. Taniguchi CM, Ueki K, Kahn R. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 2005; 115:718-727.
36. Dong X, Park S, Lin X, et al. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 2006; 116:101-114.
37. Nakae J, Kitamura T, Silver DL, Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 2001; 108:1359-1367.
38. Hirota K, Sakamaki J, Ishida J, et al. A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. J Biol Chem 2008; 283:32432-32441.
39. Porter FD. Smith-Lemli-Opitz syndrome: pathogenesis, diagnosis and management. Eur J Hum Genet 2008; 16:535-541.
40. Burkhardt R, Toh SA, Lagor WR, et al. Trib1 is a lipid-and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest 2010; 120:4410-4414.
41. Mihaylova MM, Vasquez DS, Ravnskjaer K, et al. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 2011; 145:607-621.
42. Sekine K, Chen YR, Kojima N, et al. Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J 2007; 26:3607-3615.
43. Montminy M, Koo SH, Zhang X. The CREB family: key regulators of hepatic metabolism. Ann Endocrinol (Paris) 2004; 65:73-75.
44. Winzell MS, Ahren B. The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 2004; 53(Suppl 3):S215-S219.
45. Coleman DL, Hummel KP. Studies with the mutation, diabetes, in the mouse. Diabetologia 1967; 3:238-248.
46. Ghilardi N, Ziegler S, Wiestner A, et al. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93:6231-6235.
47. Grueter CE, van Rooij E, Johnson BA, et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 2012; 149:671-683.
48. Zhang Y, Xiaoli, Zhao X, Yang F. The Mediator complex and lipid metabolism. J Biochem Pharmacol Res 2013; 1:51-55.
49. Bai L, Jia Y, Viswakarma N, et al. Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse. Hepatology 2011; 53:1164-1174.
50. Rana R, Surapureddi S, Kam W, Ferguson S, Goldstein JA. Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol Cell Biol 2011; 31:466-481.
51. Yang F, Vought BW, Satterlee JS, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 2006; 442:700-704.
52. Taubert S, Van Gilst MR, Hansen M, Yamamoto KR. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and-independent pathways in C. elegans. Genes Dev 2006; 20:1137-1149.
53. Grontved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S. MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol Cell Biol 2010; 30:2155-2169.
54. Tabata M, Rodgers JT, Hall JA, et al. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1alpha and MED1 complex. Diabetes 2014; 63:1519-1532.
55. Wang Y, Inoue H, Ravnskjaer K, et al. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci USA 2010; 107:3087-3092.
56. Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001; 104:517-529.
57. Nakajima T, Uchida C, Anderson SF, Parvin JD, Montminy M. Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. Genes Dev 1997; 11:738-747.
58. Jhala US, Canettieri G, Screaton RA, et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 2003; 17:1575-1580.
59. Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003; 423:550-555.
60. Liu Y, Dentin R, Chen D, et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 2008; 456:269-273.
61. Evans RM, Mangelsdorf DJ. Nuclear receptors, RXR, and the big bang. Cell 2014; 157:255-266.
62. Zhang K, Wang D, Song J. Cortactin is involved in transforming growth factor-beta1-induced epithelial-mesenchymal transition in AML-12 cells. Acta Biochim Biophys Sin (Shanghai) 2009; 41:839-845.
63. Yang X, Zhao M, Xia M, et al. Selective requirement for Mediator MED23 in Ras-active lung cancer. Proc Natl Acad Sci USA 2012; 109:E2813-E2822.
64. Luan B, Zhao J, Wu H, et al. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 2009; 457:1146-1149.
65. Wang Q, Jiang L, Wang J, et al. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology 2009; 49:1166-1175.
66. Wang Y, Vera L, Fischer WH, Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009; 460:534-537.
67. Wang G, Balamotis MA, Stevens JL, et al. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell 2005; 17:683-694.
68. Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 2009; 25:1105-1111.
69. Trapnell C, Williams BA, Pertea G, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010; 28:511-515.
70. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4:44-57.