Physical association of GPR54 C-terminal with protein phosphatase 2A

Biochemical and Biophysical Research Communications

Volumn 377, Issue 4, 2008, Pages 1067-1071

  Evans, Barry J ^a   Wang, Zixuan ^a   Mobley, La'Tonya ^b   Khosravi, Davood ^b   Fujii, Nobutaka ^c   Navenot, Jean Marc ^a   Peiper, Stephen C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

G protein coupled receptor; GPR54; Kisspeptin; Metastasis suppressor; PP2A; Protein complex; Protein phosphatase

Indexed keywords

ARGININE; G PROTEIN COUPLED RECEPTOR 54; KISSPEPTIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROLINE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CELL LYSATE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; YEAST;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARGININE; CELL LINE; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROLINE; PROTEIN PHOSPHATASE 2; PROTEIN SUBUNITS; RECEPTORS, G-PROTEIN-COUPLED; SRC HOMOLOGY DOMAINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 56349085553     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.108     Document Type: Article

References (28)

1. Lee J.H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., and Welch D.R. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J. Natl. Cancer Inst. 88 (1996) 1731-1737
2. Lee J.H., and Welch D.R. Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display. Int. J. Cancer 71 (1997) 1035-1044
3. Lee J.H., and Welch D.R. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res. 57 (1997) 2384-2387
4. Shirasaki F., Takata M., Hatta N., and Takehara K. Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. Cancer Res. 61 (2001) 7422-7425
5. Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., Terao Y., Kumano S., Takatsu Y., Masuda Y., Ishibashi Y., Watanabe T., Asada M., Yamada T., Suenaga M., Kitada C., Usuki S., Kurokawa T., Onda H., Nishimura O., and Fujino M. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411 (2001) 613-617
6. Sanchez-Carbayo M., Capodieci P., and Cordon-Cardo C. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Am. J. Pathol. 162 (2003) 609-617
7. Prentice L.M., Klausen C., Kalloger S., Kobel M., McKinney S., Santos J.L., Kenney C., Mehl E., Gilks C.B., Leung P., Swenerton K., Huntsman D.G., and Aparicio S.A. Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma. BMC Med. 5 (2007) 33
8. Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., and Parmentier M. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276 (2001) 34631-34636
9. Muir A.I., Chamberlain L., Elshourbagy N.A., Michalovich D., Moore D.J., Calamari A., Szekeres P.G., Sarau H.M., Chambers J.K., Murdock P., Steplewski K., Shabon U., Miller J.E., Middleton S.E., Darker J.G., Larminie C.G., Wilson S., Bergsma D.J., Emson P., Faull R., Philpott K.L., and Harrison D.C. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J. Biol. Chem. 276 (2001) 28969-28975
10. Seminara S.B. Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. Front Neuroendocrinol. 26 (2005) 131-138
11. Muller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., McClanahan T., Murphy E., Yuan W., Wagner S.N., Barrera J.L., Mohar A., Verastegui E., and Zlotnik A. Involvement of chemokine receptors in breast cancer metastasis. Nature 410 (2001) 50-56
12. Navenot J.M., Wang Z., Chopin M., Fujii N., and Peiper S.C. Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins. Cancer Res. 65 (2005) 10450-10456
13. Bockaert J., Marin P., Dumuis A., and Fagni L. The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks. FEBS Lett. 546 (2003) 65-72
14. Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol. Ther. 103 (2004) 21-80
15. Premont R.T., and Gainetdinov R.R. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu. Rev. Physiol. 69 (2007) 511-534
16. DeWire S.M., Ahn S., Lefkowitz R.J., and Shenoy S.K. Beta-arrestins and cell signaling. Annu. Rev. Physiol. 69 (2007) 483-510
17. Dorsam R.T., and Gutkind J.S. G-protein-coupled receptors and cancer. Nat. Rev. Cancer 7 (2007) 79-94
18. Sablina A.A., Chen W., Arroyo J.D., Corral L., Hector M., Bulmer S.E., DeCaprio J.A., and Hahn W.C. The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell 129 (2007) 969-982
19. Junttila M.R., Puustinen P., Niemela M., Ahola R., Arnold H., Bottzauw T., Ala-aho R., Nielsen C., Ivaska J., Taya Y., Lu S.L., Lin S., Chan E.K., Wang X.J., Grenman R., Kast J., Kallunki T., Sears R., Kahari V.M., and Westermarck J. CIP2A inhibits PP2A in human malignancies. Cell 130 (2007) 51-62
20. Mumby M. PP2A: unveiling a reluctant tumor suppressor. Cell 130 (2007) 21-24
21. Janssens V., Goris J., and Van Hoof C. PP2A: the expected tumor suppressor. Curr. Opin. Genet. Dev. 15 (2005) 34-41
22. Arroyo J.D., and Hahn W.C. Involvement of PP2A in viral and cellular transformation. Oncogene 24 (2005) 7746-7755
23. Chen W., Possemato R., Campbell K.T., Plattner C.A., Pallas D.C., and Hahn W.C. Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 5 (2004) 127-136
24. Chen W., Arroyo J.D., Timmons J.C., Possemato R., and Hahn W.C. Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity. Cancer Res. 65 (2005) 8183-8192
25. Cantley L.C., and Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96 (1999) 4240-4245
26. Myers M.P., Pass I., Batty I.H., Van der Kaay J., Stolarov J.P., Hemmings B.A., Wigler M.H., Downes C.P., and Tonks N.K. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA 95 (1998) 13513-13518
27. Myers M.P., Stolarov J.P., Eng C., Li J., Wang S.I., Wigler M.H., Parsons R., and Tonks N.K. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA 94 (1997) 9052-9057
28. Wu X., Senechal K., Neshat M.S., Whang Y.E., and Sawyers C.L. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA 95 (1998) 15587-15591