British Fertility Society Policy and Practice Committee: Adjuvants in IVF: Evidence for good clinical practice

Human Fertility

Volumn 18, Issue 1, 2015, Pages 2-15

  Nardo, Luciano G ^a   El Toukhy, Tarek ^b   Stewart, Jane ^c   Balen, Adam H ^d   Potdar, Neelam ^e  

^a Centre for Reproductive Health   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c Newcastle upon Tyne Hospitals NHS Trust   (United Kingdom)

^d SEACROFT HOSPITAL   (United Kingdom)

^e UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

Author keywords

Adjuvants; Auto immunity; IVF; Pregnancy outcome; Recurrent implantation failure; Thrombophilia

Indexed keywords

ACETYLSALICYLIC ACID; ADJUVANT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; ESTROGEN; GLYCERYL TRINITRATE; GROWTH HORMONE; HEPARIN; IMMUNOGLOBULIN; LIPID; METFORMIN; NITRIC OXIDE; PRASTERONE; PROGESTERONE; SILDENAFIL; TUMOR NECROSIS FACTOR ALPHA; UTERUS SPASMOLYTIC AGENT; VASODILATOR AGENT; ANTIDIABETIC AGENT;

ADJUVANT THERAPY; ARTICLE; EVIDENCE BASED PRACTICE; FERTILITY; FERTILIZATION IN VITRO; GOOD CLINICAL PRACTICE; HUMAN; IMMUNOTHERAPY; LIVE BIRTH; OVARY POLYCYSTIC DISEASE; PREGNANCY OUTCOME; PREGNANCY RATE; SPONTANEOUS ABORTION; ADJUVANT CHEMOTHERAPY; ADVERSE EFFECTS; EVIDENCE BASED MEDICINE; FEMALE; HEALTH CARE ORGANIZATION; INFERTILITY, FEMALE; PATHOPHYSIOLOGY; POLYCYSTIC OVARY SYNDROME; PRACTICE GUIDELINE; UNITED KINGDOM;

CHEMOTHERAPY, ADJUVANT; EVIDENCE-BASED MEDICINE; FEMALE; FERTILITY; FERTILIZATION IN VITRO; GREAT BRITAIN; HUMANS; HYPOGLYCEMIC AGENTS; INFERTILITY, FEMALE; METFORMIN; POLYCYSTIC OVARY SYNDROME; SOCIETIES, SCIENTIFIC;

EID: 84925881746     PISSN: 14647273     EISSN: 17428149     Source Type: Journal    
DOI: 10.3109/14647273.2015.985454     Document Type: Article

References (154)

1. Aghahosseini, M., Aleyassin, A., Khodaverdi, S., Esfahani, F., Mohammadbeigi, R., Movahedi, S., et al. (2011).Estradiol Supplementation during the Luteal Phase in Poor Responder Patients Undergoing in Vitro Fertilization: A Randomized Clinical Trial.Journal of Assisted Reproduction and Genetics, 28, 785-790
2. Akhtar, M.A., Sur, S., Raine-Fenning, N., Jayaprakasan, K., Thornton, J.G., & Quenby, S.(2013).Heparin for assisted reproduction.Cochrane Database of Systematic Reviews, 8, CD009452
3. Ando, T., Suganuma, N., Furuhashi, M., Asada, Y., Kondo, I., & Tomoda, Y.(1996).Successful glucocorticoid treatment for patients with abnormal autoimmunity on in vitro fertilization and embryo transfer.Journal of Assisted Reproduction and Genetics, 13, 776-781
4. Asimakopoulos, B., Demirel, C., Felberbaum, R., Waczek, S., Nikolettos, N., Köster, F., et al.(2010).Concentrations of infl ammatory cytokines and the outcome in ICSI cycles.In Vivo, 24, 495-500
5. Azem, F., Many, A., Ben Ami, I., Yovel, I., Amit, A., Lessing, J.B., & Kupferminc, M.J.(2004).Increased rates of thrombophilia in women with repeated IVF failures.Human Reproduction, 19, 368-370
6. Barad, D., & Gleicher, N.(2006).Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF.Human Reproduction, 21, 2845-2849
7. Barad, D., Brill, H., & Gleicher, N.(2007).Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function.Journal of Assisted Reproduction and Genetics, 24, 629-634
8. Bergh, C., Nilsson, L., Hillensjo, T., Borg, T., Wikland, M., & Hamberger, L.(1994).Adjuvant growth hormone treatment during in vitro fertilization: a randomized, placebo-controlled study.Fertility & Sterility, 62, 113-120
9. Berker, B., Taskin, S., Kahraman, K., Taskin, E.A., Atabekoglu, C., & Sonmezer, M.(2011).The role of low-molecular-weight heparin in recurrent implantation failure: a prospective, quasi-randomized, controlled study.Fertility & Sterility, 95, 2499-2502
10. Bongartz, T., Sutton, A.J., Sweeting, M.J., Buchan, I., Matteson, E.L., & Montori, V.(2006).Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-Analysis of rare harmful effects in randomized controlled trials.JAMA, 295, 2275-2285
11. Bongartz, T., Warren, F.C., Mines, D., Matteson, E.L., Abrams, K.R., & Sutton, A.J.(2009).Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-Analysis of randomised controlled trials.Annals of Rheumatic Diseases, 68, 1177-1183
12. Boomsma, C.M., Eijkemans, M.J.C, Hughes, E.G., Visser, G.H.A., Fauser, B.C.J.M., & Macklon, N.S.(2006).A meta-Analysis of pregnancy outcomes in women with polycystic ovary syndrome.Human Reproduction Update, 12, 673-683
13. Boomsma, C.M.& Macklon, N.S.(2008).Does glucocorticoid therapy in the peri-implantation period have an impact on IVF outcomes?.Current Opinionin Obstetrics and Gynecolology, 20, 249-256
14. Boomsma, C.M., Keay, S.D., & Macklon, N.S.(2012).Periimplantation glucocorticoid administration for assisted reproductive technology cycles.Cochrane Database of Systematic Reviews, 6, CD005996
15. Bosdou, J.K., Venetis, C.A., Kolibianakis, E.M., Toulis, K.A., Goulis, D.G., Zepiridis, L., & Tarlatzis, B.C.(2012).The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: a systematic review and metaanalysis .Human Reproduction Update, 18, 127-145
16. Brewer, C., Acharya, S., Thake, F., Tang, T., & Balen, A.(2010).Effect of metformin taken in the fresh in vitro fertilization/.intracytoplasmic sperm injection cycle upon subsequent frozen embryo replacement in women with polycystic ovary syndrome.Human Fertility, 13, 134-142
17. Carbone, J.(2007).Adverse reactions and pathogen safety of intravenous immunoglobulin.Current Drug Safety, 2, 9-18
18. Casson, P.R., Lindsay, M.S., Pisarska, M.D., Carson, S.A., & Buster, J.E.(2000).Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series.Human Reproduction, 15, 2129-2132
19. Chamley, L.W., Duncalf, A.M., Mitchell, M.D., & Johnson, P.M.(1998).Action of anticardiolipin and antibodies to beta2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death.Lancet, 352, 1037-1038
20. Chang, E.M., Han, J.E., Won, H.J., Kim, Y.S., Yoon, T.K., & Lee, W.S.(2012).Effect of estrogen priming through luteal phase and stimulation phase in poor responders in in vitro fertilization.Journal of Assisted Reproduction and Genetics, 29, 225-230
21. Check, J.H., Graziano, V., Lee, G., Nazari, A., Choe, J.K., & Dietterich, C.(2004).Neither sildenafi l nor vaginal estradiol improves endometrial thickness in women with thin endometria after taking oral estradiol in graduating dosages.Clinicaland Experimental Obstetrics & Gynecology, 31, 99-102
22. Chwalisz, K., Winterhager, E., Thienel, T., & Garfi eld, R.E.(1999).Synergisticrole of nitric oxide and progesterone during the establishment of pregnancyin the rat.Human Reproduction, 14, 542-552
23. Clarke, D.A., Coulam, C.B., & Stricker, R.B.(2006).Is intravenous immunoglobulins (IVIG) effi cacious in early pregnancy failure?.A critical review and meta-Analysis for patients who fail in vitro fertilization and embryo transfer (IVF).Journal of Assisted Reproduction and Genetics, 23, 1-13
24. Clark, D.A.(2009).Should anti-TNF-Alpha therapy be offered to patients with infertility and recurrent spontaneous abortion?.American Journalof Reproductive Immunology, 61, 107-112
25. Clark, D.A.(2010).Anti-TNF- Therapy in immune-mediated subfertility: state of the art.Journal of Reproductive Immunology, 85, 15-24
26. Coulam, C.B., Jeyendran, R.S., Fishel, L.A., & Roussev, R.(2006).Multiple thrombophilic gene mutations are risk factors for implantation failure.Reproductive Biomedicine Online, 12, 322-327
27. Dentali, F., Ageno, W., Rezoagli, E., Rancan, E., Squizzato, A., Middeldorp, S., et al. (2012).Low-dose Aspirin for in Vitro Fertilization or Intracytoplasmic Sperm Injection: A Systematic Review and A Meta-Analysis of the Literature.Journalof Thrombosis and Haemostasis, 10, 2075-2085
28. Di Simone, N., Meroni, P.L., de Papa, N., Raschi, E., Caliandro, D., De Carolis, C.S., et al.(2000).Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I.Arthritis & Rheumatism, 43, 140-150
29. Doldi, N., Persico, P., Di Sebastiano, F., Marsiglio, E., & Ferrari, A.(2006).Gonadotropin-releasing hormone antagonist and metformin for treatment of polycystic ovary syndrome patients undergoing in vitro fertilization-embryo transfer.Gynecological Endocrinology, 22, 235-238
30. Duffy, J.M.N., Ahmad, G., Mohiyiddeen, L., Nardo, L.G., & Watson, A.(2010).Growth hormone for in vitro fertilization.Cochrane Database of Systematic Reviews, 1, CD000099
31. Eftekhar, M., Afl atoonian, A., Mohammadian, F., & Eftekhar, T.(2013).Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology.Archives of Gynecology and Obstetrics, 287, 1017-1021
32. Elram, T., Simon, A., Israel, S., Revel, A., Shveiky, D., & Laufer, N.(2005).Treatment of recurrent IVF failure and human leukocyte antigen similarity by intravenous immunoglobulin.Reproductive Biomedicine Online, 11, 745-749
33. Erden, O., Imir, A., Guvenal, T., Muslehiddinoglu, A., Arici, S., Cetin, M., & Cetin, A.(2006).Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry.Human Reproduction, 21, 3014-3018
34. Falconer, H., Sundqvist, J., Gemzell-Danielsson, K., von Schoultz, B., D Hooghe, T.M., & Fried, G.(2009).IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-Mü llerian hormone.Reproductive Biomedicine Online, 18, 582-588
35. Fanchin, R., Righini, C., Olivennes, F., Taylor, S., de Ziegler, D., & Frydman, R.(1998).Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization.Human Reproduction, 13, 1968-1974
36. Fasouliotis, S.J., Spandorfer, S.D., Witkin, S.S., Schattman, G., Liu, H.C., Roberts, J.E., & Rosenwaks, Z.(2004).Maternal serum levels of interferon-gamma and interleukin-2 soluble receptor-Alpha predict the outcome of early IVF pregnancies.Human Reproduction, 19, 1357-1363
37. Fawzy, M.& El-Refaeey, A.A.(2014).Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure?.Archives of Gynecology and Obstetrics, 289, 677-680
38. Feldmeyer, L., Benden, C., Haile, S.R., Boehler, A., Speich, R., French, L.E., & Hofbauer, G.F.(2010).Not all intravenous immunoglobulin preparations are equally well tolerated.Acta Dermato-Venereologica, 90, 494-497
39. Fluhr, H., Spratte, J., Ehrhardt, J., Steinmuller, F., Licht, P., Zygmunt, M.(2010).Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells.Fertility & Sterility, 93, 2581-2587
40. Fouany, M.R.& Sharara, F.I.(2013).Is there a role for DHEA supplementation in women with diminished ovarian reserve?.Journal of Assisted Reproduction and Genetics, 30, 1239-1244
41. Gelbaya, T.A., Kyrgiou, M., Li, T.C., Stern, C., & Nardo, L.G.(2007).Low-dose aspirin for in vitro fertilization: a systematic review and meta-Analysis.Human Reproduction Update, 13, 357-364
42. Geva, E., Amit, A., Lerner-Geva, L., Azem, F., Yovel, I., & Lessing, J.B.(1995).Autoimmune disorders: another possible cause for in-vitro fertilization and embryo transfer failure.Human Reproduction, 10, 2560-2563
43. Geva, E., Amit, A., Lerner-Geva, L., Yaron, Y., Daniel, Y., Schwartz, T., et al.(2000).Prednisone and aspirin improve pregnancy rate in patients with reproductive failure and autoimmune antibodies: a prospective study.American Journal of Reproductive Immunology, 43, 36-40
44. Girardi, G., Redecha, P., & Salmon, J.E.(2004).Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation.Nature Medicine, 10, 1222-1226
45. Gorkemli, H., Ak, D., Akyurek, C., Aktan, M., & Duman, S.(2004).Comparison of pregnancy outcomes of progesterone or progesteroné estradiol for luteal phase support in ICSI-ET cycles.Gynecologic and Obstetric Investigation, 58, 140-144
46. Granato, D., Blum, S., Rössle, C., Le Boucher, J., Malnoë, A., & Dutot, G.(2000).Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro.Journal of Parenteraland Enteral Nutrition, 24, 113-118
47. Griesinger, G., Kolibianakis, E.M., Venetis, C., Diedrich, K., & Tarlatzis, B.(2010).Oral contraceptive pretreatment signifi cantly reduces ongoing pregnancy likelihood in gonadotrophinreleasing hormone antagonist cycles: an updated meta-Analysis.Fertility & Sterility, 94, 2382-2384
48. Groeneveld, E., Broeze, K.A., Lambers, M.J., Haapsamo, M., Dirckx, K., Schoot, B.C., et al.; IPD MARIA study group.(2011).Is aspirin effective in women undergoing in vitro fertilization (IVF)?.Results from an individual patient data meta-Analysis (IPD MA).Human Reproduction Update, 17, 501-509
49. Groeneveld, E., Lambers, M.J., Lambalk, C.B., Broeze, K.A., Haapsamo, M., de Sutter, P., et al.(2013).Preconceptional low-dose aspirin for the prevention of hypertensive pregnancy complications and preterm delivery after IVF: a metaanalysis with individual patient data.Human Reproduction, 28, 1480-1488
50. Harper, K., Proctor, M., & Hughes, E.(2003).Growth hormone for in vitro fertilization.Cochrane Database of Systematic Reviews, 3, CD000099
51. Hasegawa, I., Yamanoto, Y., Suzuki, M., Murakawa, H., Kurabayashi, T., Takakuwa, K., & Tanaka, K.(1998).Prednisolone plus lowdose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization.Fertility & Sterility, 70, 1044-1048
52. Heilmann, L., Schorsch, M., & Hahn, T.(2010).CD3-CD56- CD16-natural killer cells and improvement of pregnancy outcome in IVF/ICSI failure after additional IVIG-Treatment.American Journal of Reproductive Immunology, 63, 263-265
53. Hillier, S.G.& Tetsuka, M.(1997).Role of androgens in follicle maturation and atresia.Baillieres Clinical Obstetrics and Gynaecology, 11, 249-260
54. Homburg, R.& Ostergaard, H.(1995).Clinical applications of growth hormone for ovarian stimulation.Human Reproduction Update, 1, 264-275
55. Howles, C.M., Loumaye, E., Germond, M., Yates, R., Brinsden, P., Healy, D., et al.(1999).Does growth hormone-releasing factor assist follicular development in poor responder patients undergoing ovarian stimulation for in-vitro fertilization?.Human Reproduction, 14, 1939-1943
56. Huirne, J.A., Hugues, J.N., Pirard, C., Fischl, F., Sage, J.C., Pouly, J.L., et al.(2006).Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicenter, phase IIIb study.Human Reproduction, 21, 1408-1415
57. Hutchinson-Williams, K.A., Lunenfeld, B., Diamond, M.P., Lavy, G., Boyers, S.P., & DeCherney, A.H.(1989).Human chorionic gonadotropin, estradiol, and progesterone profi les in conception and non-conception cycles in an in vitro fertilization program.Fertility & Sterility, 52, 441-445
58. IVF Worldwide Survey.(2010).Poor responders.How to defi ne diagnoseandtreat.www.ivf-worldwide.com/survey/poor-responders/.results-poor responders.html.Last access Jan 2014
59. Jee, B.C., Suh, C.S., Kim, S.H., Kim, Y.B., & Moon, S.Y.(2010).Effects of estradiol supplementation during the luteal phase of in vitro fertilization cycles: a meta-Analysis.Fertility & Sterility, 93, 428-436
60. Jerzak, M., Niemiec, T., Nowakowska, A., Klochowicz, M., Górski, A., & Baranowski, W.(2010).First successful pregnancy after addition of enoxaparin to sildenafi l and etanercept immunotherapy in woman with fi fteen failed IVF cycles - case report.American Journal of Reproductive Immunology, 64, 93-96
61. Kalu, E., Bhaskaran, S., Thum, M.Y., Vishwanatha, R., Croucher, C., Sherriff, E., et al.(2008).Serial estimation of Th1: th2 cytokines profi le in women undergoing in-vitro fertilization-embryo transfer.American Journal of Reproductive Immunology, 59, 206-211
62. Kara, M., Aydin, T., Aran, T., Turktekin, N., & Ozdemir, B.(2014).Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve?.European Journal of Obstetrics & Gynecolology and Reproductive Biology, 173, 63-65
63. Khairy, M., Banerjee, K., El-Toukhy, T., Coomarasamy, A., & Khalaf, Y.(2007).Aspirin in women undergoing in vitro fertilization treatment: a systematic review and meta-Analysis.Fertility & Sterility, 88, 822-831
64. Kim, C.H., Chae, H.D., & Chang, Y.S.(1999).Pyridostigmine cotreatment for controlled ovarian hyperstimulation in low responders undergoing in vitro fertilization-embryo transfer.Fertility & Sterility, 71, 652-657
65. Kolibianakis, E.M., Venetis, C.A., Diedrich, K., Tarlatzis, B.C., & Griesinger, G.(2009).Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in-vitro fertilization: a systematic review and metaanalysis .Human Reproduction Update, 15, 613-622
66. Kolibianakis, E.M., Venetis, C.A., & Tarlatzis, B.C.(2011).DHEA administration in poor responders.Human Reproduction, 26, 730-731
67. Kucuk, T., Kozinoglu, H., & Kaba, A.(2008).Growth hormone co-Treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial.Journal of Assisted Reproduction and Genetics, 25, 123-127
68. Kutteh, W.H., Yetman, D.L., Chantilis, S.J., & Crain, J.(1997).Effect of antiphospholipid antibodies in women undergoing in-vitro fertilization: role of heparin and aspirin.Human Reproduction, 2, 1171-1175
69. Kwak-Kim, J., Han, A.R., Gilman-Sachs, A., Fishel, S., Leong, M., & Shoham, Z.(2013).Current trends of reproductive immunology practices in in vitro fertilization (IVF) - A fi rst world survey using IVF-Worldwide.com.American Journal of Reproductive Immunology, 69, 12-20
70. Kwon, S.K., Kim, C.H., Lee, K.H., Jeon, I.K., Ahn, J.W., Kim, S.H., et al.(2013).Luteal estradiol supplementation in gonadotropinreleasing hormone antagonist cycles for infertile patients in vitro fertilization.Clinicaland Experimental Reproductive Medicine, 40, 131-134
71. Lesny, P., Killick, S.R., Tetlow, R.L., Robinson, J., & Maguiness, S.D.(1998).Uterine junctional zone contractions during assisted reproduction cycles.Human Reproduction Update, 4, 440-445
72. Li, J., Chen, Y., Liu, C., Hu, Y., & Li, L.(2013).Intravenous immunoglobulin treatment for repeated IVF/ICSI failure and unexplained infertility: a systematic review and a meta-Analysis.American Journal of Reproductive Immunology, 70, 434-447
73. Lin, H., Li, Y., Li, L., Wang, W., Zhang, Q., Chen, X., & Yang, D.(2013).Oral oestradiol supplementation as luteal support in IVF/ICSI cycles: a prospective, randomized controlled study.European Journal of Obstetrics & Gynecology and Reproductive Biology, 167, 171-175
74. Linhardt, R.J., Wang, H.M., & Ampofo, S.A.(1992).New methodologies in heparin structure analysis and the generation of LMW heparins.Advances in Experimental Medicine and Biology, 313, 37-47
75. Lukaszuk, K., Liss, J., Lukaszuk, M., & Maj, B.(2005).Optimization of estradiol supplementation during the luteal phase improves the pregnancy rate in women undergoing in vitro fertilizationembryo transfer cycles.Fertility & Sterility, 83, 1372-1376
76. Ma, C.H., Yan, L.Y., Qiao, J., Sha, W., Li, L., Chen, Y., & Sun, Q.Y.(2010).Effects of tumor necrosis factor-Alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment.Fertility & Sterility, 93, 920-926
77. Mendoza, C., Cremades, N., Ruiz-Requena, E., Martinez, F., Ortega, E., Bernabeu, S., & Tesarik, J.(1999).Relationship between fertilization results after intracytoplasmic sperm injection, and intrafollicular steroid, pituitary hormone and cytokine concentrations.Human Reproduction, 14, 628-635
78. Mendoza, C., Ruiz-Requena, E., Ortega, E., Cremades, N., Martinez, F., Bernabeu, R., et al. (2002).Follicular Fl Uid Markers of Oocyte Developmental Potential.Human Reproduction, 17, 1017-1022
79. Mé né zo, Y., Dale, B., & Cohen, M.(2010).DNA damage and repair in human oocytes and embryos: a review.Zygote, 18, 357-365
80. Moraru, M., Carbone, J., Alecsandru, D., Castillo-Rama, M., Garcí a-Segovia, A., Gil, J., et al.(2012).Intravenous immunoglobulin treatment increased live birth rate in a Spanish cohort of women with recurrent reproductive failure and expanded CD56( ) cells.American Journal of Reproductive Immunology, 68, 75-84
81. Morizaki, N., Morizaki, J., Hayashi, R.H., & Garfi eld, R.E.(1989).A functional and structural study of the innervation of the human uterus.American Journal of Obstetrics & Gynecology, 160, 218-228
82. Nardo, L.G., Granne, I., & Stewart, J.(2009).Policy and Practice Committee of the British Fertility Society.Medical adjuncts in IVF: evidence for clinical practice.Human Fertility, 12, 1-13
83. Nardo, L.G., Bosch, E., Lambalk, C.B, & Gelbaya, T.A.(2013).Controlled ovarian hyperstimulation regimens: a review of the available evidence for clinical practice.Produced on behalf of the BFS Policy and Practice Committee.Human Fertility, 16, 144-150
84. Narkwichean, A., Maalouf, W., Campbell, B.K., & Jayaprakasan, K.(2013).Effi cacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a metaanalysis .Reproductive Biology and Endocrinology, 16, 11: 44
85. Narkwichean, A., Jayaprakasan, K., Maalouf, W.E., Hernandez-Medrano, J.H., Pincott-Allen, C., & Campbell, B.K.(2014).Effects of dehydroepiandrosterone on in vivo ovine follicular development.Human Reproduction, 29, 146-154
86. National Institute for Health and Clinical Excellence (NICE).(2004).Fertility: assessment and treatment for people with fertility problems.Clinical Guideline, CG11, 1.12.3
87. National Institute for Health and Clinical Excellence (NICE).(2013).Fertility: assessment and treatment for people with fertility problems.Clinical Guideline, CG156, 1.12.4
88. Nduwke, G.(2011).Recurrent embryo implantation failure after in vitro fertilization: improved outcome following intralipid infusion in women with elevated T helper 1 response.Human Fertility, 14, 21-22
89. Nielsen, M.E., Rasmussen, I.A., Kristensen, S.G., Christensen, S.T., Møllgård, K., Wreford Andersen, E., et al.(2011).In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fl uid correlate with FSH receptor mRNA.Molecular Human Reproduction, 17, 63-70
90. Noci, I., Milanini, M.N., Ruggiero, M., Papini, F., Fuzzi, B., & Artini, P.G.(2011).Effect of dalteparin sodium administration on IVF outcome in non-Thrombophilic young women: a pilot study.Reproductive Biomedicine Online, 22, 615-620
91. Ohl, J., Lefébvre-Maunoury, C., Wittemer, C., Nisand, G., Laurent, M.C., & Hoffmann, P.(2002).Nitric oxide donors for patients undergoing IVF.A prospective, double-blind, randomized, placebo-controlled trial.Human Reproduction, 17, 2615-2620
92. Okazaki, M., Matsuyama, T., Kohno, T., Shindo, H., Koji, T., Morimoto, Y., & Ishimaru, T.(2005).Induction of epithelial cell apoptosis in the uterus by a mouse uterine ischemia-reperfusion model: possible involvement of tumor necrosis factor-Alpha.Biology of Reproduction, 72, 1282-1288
93. Owen, E.J., Ostergaard, H., Shoham, Z., Jacobs, H.S., & Mason, B.A.(1991).Co-Treatment with growth hormone, after pituitary suppression, for ovarian stimulation in in vitro fertilization: a randomized, double-blind, placebo-control trial.Fertility & Sterility, 56, 1104-1110
94. Palabrica, F.R., Kwong, S.L., & Padua, F.R.(2013).Adverse events of intravenous immunoglobulin infusions: a ten-year retrospective study.Asia Pacifi c Allergy, 3, 249-256
95. Palomba, A., Falbo, A., Orio, F.Jr., & Zullo F.(2009).Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-Analysis of randomized controlled trials.Fertility & Sterility, 92, 1646-1658
96. Patrono, C., Garcí a Rodrí guez, L.A., Landolfi, R., & Baigent, C.(2005).Low-dose aspirin for the prevention of atherothrombosis.New England Journal of Medicine, 353, 2373-2383
97. Pinheiro, O.L., Cavagna, M., Baruffi, R.L., Mauri, A.L., Petersen, C., & Franco, J.G.Jr.(2003).Administration of beta2-Adrenergic agonists during the peri-implantation period does not improve implantation or pregnancy rates in intracytoplasmic sperm injection (ICSI) cycles.Journal of Assisted Reproduction and Genetics, 20, 513-516
98. Pitteloud, N., Mootha, V.K., Dwyer, A.A., Hardin, M., Lee, H., Eriksson, K.F., et al. (2005).Relationship between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men.Diabetes Care, 28, 1636-1642
99. Polanski, L.T., Barbosa, M.A., Martins, W.P., Baumgarten, M.N., Campbell, B., Brosens, J., et al.(2014).Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques: a systematic review of literature.Human Reproduction, 29, 65-75
100. Potdar, N., Gelbaya, T.A., Konje, J.C., & Nardo, L.G.(2013).Adjunct low-molecular-weight heparin to improve live birth rate after recurrent implantation failure: a systematic review and metaanalysis.Human Reproduction Update, 19, 674-684
101. Poustie, V., Dodd, S., & Drakeley, A.(2007).Low dose aspirin for in vitro fertilisation.Cochrane Database of Systematic Reviews, 17, CD004832
102. Qublan, H.S., Eid, S.S., Ababneh, H.A., Amarin, Z.O., Smadi, A.Z., Al-Khafaji, F.F., & Khader, Y.S.(2006).Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure.Human Reproduction, 21, 2694-2698
103. Qublan, H., Amarin, Z., Dabbas, M., Farraj, A.E., Beni-Merei, Z., Al-Akash, H., et al.(2008).Low-molecular-weight heparin in the treatment of recurrent IVF-ET failure and thrombophilia: a prospective randomized placebo-controlled trial.Human Fertility, 11, 246-253
104. Revelli, A., Casano, S., Piane, L.D., Grassi, G., Gennarelli, G., Guidetti, D., & Massobrio, M.(2009).A retrospective study on IVF outcome in euthyroid patients with anti-Thyroid antibodies: effects of levothyroxine, acetyl-salicylic acid and prednisolone adjuvant treatments.Reproductive Biology and Endocrinology, 7, 137
105. Rogolino, A., Coccia, M.E., Fedi, S., Gori, A.M., Cellai, A.P., Scarselli, G.F., et al.(2003).Hypercoagulability, high tissue factor and low tissue factor pathway inhibitor levels in severe ovarian hyperstimulation syndrome: possible association with clinical outcome.Blood Coagulation & Fibrinolysis, 14, 277-282
106. Ruopp, M.D., Collins, T.C., Whitcomb, B.W., & Schisterman, E.F.(2008).Evidence of absence or absence of evidence?A reanalysis of the effects of low-dose aspirin in in vitro fertilization.Fertility & Sterility, 90, 71-76
107. Roussev, R.G., Acacio, B., Ng, S.C., & Coulam, C.B.(2008).Duration of intralipid's suppressive effect on NK cell's functional activity.American Journal of Reproductive Immunology, 60, 258-263
108. Schenk, L.M., Morris, J.P., Cox, B., Lecte, J., Abuhamed, A., Ochninger, S., et al.(1996).Heparin and aspirin treatment yields higher implantation rates in IVF patients with antiphospholipid antibodies seropositivity compared to untreated seronegative patients (abstract).Proceedings of the Annual Meeting of the American Society of Reproductive Medicine, Boston, USA
109. Sengupta, J., Dhawan, L., Lalitkumar, P.G., & Ghosh, D.(2005).Nitric oxide in blastocyst implantation in rhesus monkey.Reproduction, 130, 321-332
110. Seshadri, S., Sunkara, S.K., Khalaf, Y., El-Toukhy, T., & Hamoda, H.(2012).Effect of heparin on the outcome of IVF treatment: a systematic review and meta-Analysis.Reproductive Biomedicine Online, 25, 572-584
111. Shaker, A.G., Fleming, R., Jamieson, M.E., Yates, R.W., & Coutts, J.R.(1993).Assessments of embryo transfer after in-vitro fertilization: effects of glyceryl trinitrate.Human Reproduction, 8, 1426-1428
112. Sher, G., Feinman, M., Zouves, C., Kuttner, G., Maassarani, G., Salem, R., et al.(1994).High fecundity rates following invitro fertilization and embryo transfer in antiphospholipid antibodyseropositive women treated with heparin and aspirin.Human Reproduction, 9, 2278-2283
113. Sher, G., Matzner, W., Feinman, M., Maassarani, G., Zouves, C., Chong, P., & Ching, W.(1998).The selective use of heparin/.aspirin therapy, alone or in combination with intravenous immunoglobulin G, in the management of antiphospholipid antibody-positive women undergoing in vitro fertilization.American Journal of Reproductive Immunology, 40, 74-82
114. Sher, G., & Fisch, J.D.(2000).Vaginal sildenafi l (Viagra): a preliminary report of a novel method to improve uterine artery blood fl ow and endometrial development in patients undergoing IVF.Human Reproduction, 15, 806-809
115. Sher, G., & Fisch, JD.(2002).Effect of vaginal sildenafi l on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development.Fertility & Sterility, 78, 1073-1076
116. Siristatidis, C.S., Dodd, S.R., & Drakeley, A.J.(2011).Aspirin for in vitro fertilisation.Cochrane Database of Systematic Reviews, 8, CD004832
117. Siristatidis, C., Chrelias, C., Creatsas, M., Varounis, C., Vrachnis, N., Iliodromiti, Z., & Kassanos, D.(2013).Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial.Human Fertility, 16, 207-210
118. Smitz, J., Bourgain, C., van Waesberghe, L., Camus, M., Devroey, P., & van Steirteghem, A.C.(1993).A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in buserelin and HMG induced superovulation.Human Reproduction, 8, 40-45
119. Smulders, B., van Oirschot, S.M., Farquhar, C., Rombauts, L., & Kremer, J.A.M.(2010).Oral contraceptive pill, progestogen or estrogen pre-Treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques.Cochrane Database of Systematic Reviews, 1, CD006109
120. Souayah, N., Hasan, A., Khan, H.M., Yacoub, H.A., & Jafri, M.(2011).The safety profi le of home infusion of intravenous immunoglobulin in patients with neuroimmunologic disorders.Journal of Clinical Neuromuscular Disease, 12, S1-S10
121. Spiliotis, B.E.(2003).Growth hormone insuffi ciency and its impact on ovarian function.Annals of the New York Academy of Sciences, 997, 77-84
122. Stern, C., Chamley, L., Norris, H., Hale, L., & Baker, H.W.(2003).A randomized, double-blind, placebo-controlled trial of heparin and aspirin for women with in vitro fertilization implantation failure and antiphospholipid or antinuclear antibodies.Fertility & Sterility, 80, 376-383
123. Suikkari, A.M., MacLachlan, V., Koistinen, R., Seppälä, M., & Healy, D.L.(1996).Double-blind placebo controlled study: human biosynthetic growth hormone for assisted reproductive technology.Fertility & Sterility, 65, 800-805
124. Sunkara, S.K., Pundir, J., & Khalaf, Y.(2011).Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-Analysis.Reproductive Biomedicine Online, 22, 545-555
125. Swanton, A., Lighten, A., Granne, I., McVeigh, E., Lavery, S., et al.(2011).Do women with ovaries of polycystic morphology without any other features of PCOS benefi t from shortterm metformin co-Treatment during IVF?.A double-blind, placebo-controlled, randomized trial.Human Reproduction, 26, 2178-2184
126. Takasaki, A., Tamura, H., Miwa, I., Taketani, T., Shimamura, K., & Sugino, N.(2010).Endometrial growth and uterine blood fl ow: a pilot study for improving endometrial thickness in the patients with a thin endometrium.Fertility & Sterility, 93, 1851-1858
127. Tamada, H., Higashiyama, C., Takano, H., Kawate, N., Inaba, T., & Sawada, T.(1999).The effects of heparin-binding epidermal growth factor-like growth factor on preimplantation-embryo development and implantation in the rat.Life Science, 64, 1967-1973
128. Tang, T., Glanville, J., Orsi, N., Barth, J.H., & Balen AH.(2006).The use of metformin for women with PCOS undergoing IVF treatment.Human Reproduction, 21, 1416-1425
129. Tang, T., Lord, J.M., Norman, R.J., Yasmin, E., & Balen, A.H.(2012).Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, Dchiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.Cochrane Database of Systematic Reviews, 5, CD003053
130. Taniguchi, F.(2005).Results of Prednisolone given to improve the outcome of in vitro fertilization-embryo transfer in women with anti-nuclear antibodies.Journal of Reproductive Medicine, 50, 383-388
131. Tay, P.Y., & Lenton, E.A.(2003).Inhibition of progesterone secretion by oestradiol administered in the luteal phase of assisted conception cycles.Medical Journal of Malaysia, 58, 187-195
132. Telfer, J.F., Irvine, G.A., Kohnen, G., Campbell, S., & Cameron, I.T.(1997).Expression of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium.Molecular Human Reproduction, 3, 69-75
133. Tesarik, J., Hazout, A., & Mendoza, C.(2005).Improvement of delivery and live birth rates after ICSI in women aged 40 years by ovarian co-stimulation with growth hormone.Human Reproduction, 20, 2536-2541.The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Thessaloniki, Greece
134. Tarlatzis, B.C., Fauser, J.M., Chang, J., Franks, S., Legro, R., Rebar, R.W., et al.(2008).Consensus on infertility treatment related to polycystic ovary syndrome.Human Reproduction, 23 : 462-477
135. Thum, M.Y., Abdalla, H.I., Bhaskaran, S., Harden, E.L., Ford, B., Sumar, N., et al.(2007).The relationship of systemic TNF-Alpha and IFN-gamma with IVF treatment outcome and peripheral blood NK cells.American Journal of Reproductive Immunology, 57, 210-217
136. Tonguc, E., Var, T., Ozyer, S., Citil, A., & Dogan, M.(2011).Estradiol supplementation during the luteal phase of in vitro fertilization cycles: a prospective randomised study.European Journal of Obstetrics & Gynecology and Reproductive Biology, 154, 172-176
137. Tso, L.O., Costello, M.F., Albuquerque, L.E., Andriolo, R.B., & Freitas, V.(2009).Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.Cochrane Database of Systematic Reviews, 2, CD006105
138. Urman, B., Ata, B., Yakin, K., Alatas, C., Aksoy, S., Mercan, R., & Balaban, B.(2009).Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial.Human Reproduction, 24, 1640-1647
139. van Gestel, I., IJland, M.M., Hoogland, H.J., & Evers, J.L.(2003).Endometrial wave-like activity in the non-pregnant uterus.Human Reproduction Update, 9, 131-138
140. Vane, J.R., Flower, R.J., & Botting, R.M.(1990).History of aspirin and its mechanism of action.Stroke, 21, 12-23
141. Vanky, E., Stridsklev, S., Heimstad, R., Romundstad, P., Skogoy, K., Kleggetveit, O., et al. (2010).Metformin Versus Placebo from Fi Rst Trimester to Delivery in Polycystic Ovary Syndrome: A Randomized, Controlled Multicenter Study.Journal of Clinical Endocrinology & Metabolism, 95, 448-455
142. Virro, M.R., Winger, E.E., & Reed, J.L.(2012).Intravenous immunoglobulin for repeated IVF failure and unexplained infertility.American Journal of Reproductive Immunology, 68, 218-225
143. Wada, I., Hsu, C.C., Williams, G., Macnamee, M.C., & Brinsden, P.R.(1994).The benefi ts of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception.Human Reproduction, 9, 1954-1957
144. Walters, K.A., Allan, C.M., & Handelsman, D.J.(2008).Androgen actions and the ovary.Biology of Reproduction, 78, 380-389
145. Walters, K.A., Simanainen, U., & Handelsman, D.J.(2010).Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models.Human Reproduction Update, 16, 543-558
146. Winger, E.E., Reed, J.L., Ashoush, S., Ahuja, S., El-Toukhy, T., & Taranissi, M.(2009).Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF.American Journal of Reproductive Immunology, 61, 113-120
147. Winger, E.E., Reed, J.L., Ashoush, S., El-Toukhy, T., Ahuja, S., & Taranissi, M.(2011a).Elevated preconception CD56 16ánd/or Th1: Th2 levels predict benefi t from IVIG therapy in subfertile women undergoing IVF.American Journalof Reproductive Immunology, 66, 394-403
148. Winger, E.E., Reed, J.L., Ashoush, S., El-Toukhy, T., Ahuja, S., & Taranissi, M.(2011b).Degree of TNF-/IL-10 cytokine elevation correlates with IVF success rates in women undergoing treatment with Adalimumab (Humira) and IVIG.American Journal of Reproductive Immunology, 65, 610-618
149. Winger, E.E., Reed, J.L., Ashoush, S., El-Toukhy, T., & Taranissi M.(2012).Die-off ratio correlates with increased TNF-: IL-10 ratio and decreased IVF success rates correctable with humira.American Journal of Reproductive Immunology, 68, 428-437
150. Wiser, A., Gonen, O., Ghetler, Y., Shavit, T., Berkovitz, A., & Shulman, A.(2010).Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.Human Reproduction, 25, 2496-2500
151. Yakin, K., & Urman, B.(2011).DHEA as a miracle drug in the treatment of poor responders; hype or hope?.Human Reproduction, 26, 1941-1944
152. Yilmaz, N., Uygur, D., Inal, H., Gorkem, U., Cicek, N., & Mollamahmutoglu, L.(2013).Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count.European Journal of Obstetrics & Gynecology and Reproductive Biology, 169, 257-260
153. Ying, Y., Zhong, Y.P., Zhou, C.Q., Xu, Y.W., Wang, Q., Li, J, et al.(2012).A retrospective study on IVF outcome in patients with anticardiolipin antibody: effects of methylprednisolone plus low-dose aspirin adjuvant treatment.Journal of Reproductive Immunology, 94, 196-201
154. Zhang, X., Wang, H.M., Lin, H.Y., Liu, G.Y., Li, Q.L., & Zhu, C.(2004).Regulation of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) during mouse peri-implantation: role of nitric oxide.Placenta, 25, 243-252