Intravenous Immunoglobulin Treatment Increased Live Birth Rate in a Spanish Cohort of Women with Recurrent Reproductive Failure and Expanded CD56 + Cells

American Journal of Reproductive Immunology

Volumn 68, Issue 1, 2012, Pages 75-84

  Moraru, Manuela ^a,b   Carbone, Javier ^a   Alecsandru, Diana ^a   Castillo Rama, Marcela ^a   García Segovia, Aurea ^c   Gil, Juana ^a   Alonso, Bárbara ^a   Aguarón, Angel ^a   Ramos Medina, Rocío ^a   Martínez de María, Juan ^c   Oliver Miñarro, Desamparados ^a   Rodríguez Mahou, Margarita ^a   Ortega, Virginia ^a   Caballero, Pedro ^c   Meliá, Elena ^d   Vidal, Juan ^d   Cianchetta Sivori, Malena ^a   Esteban, Carmen ^a   Vargas Henny, Loreto ^a   Dale, Jonathan ^a   Ortiz Quintana, Luis ^a   Fernández Cruz, Eduardo ^a   Sánchez Ramón, Silvia ^a   more..

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^c Clinica Tambre   (Spain)

^d HOSPITAL RUBER INTERNACIONAL   (Spain)

Author keywords

CD56 + cells; In vitro fertilization; Intravenous immunoglobulin; NK cells; Recurrent miscarriage

Indexed keywords

CD16 ANTIGEN; CD3 ANTIGEN; CD56 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G;

ADULT; ARTICLE; ASTHENIA; CELL EXPANSION; CELL SUBPOPULATION; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERANCE; FEMALE; FERTILIZATION IN VITRO; HEADACHE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOTHERAPY; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; NATURAL KILLER CELL; OUTCOME ASSESSMENT; PREGNANCY; PREGNANCY DISORDER; PREGNANCY RATE; PRIORITY JOURNAL; RECURRENT ABORTION; RECURRENT IMPLANTATION FAILURE; SPAIN;

ABORTION, HABITUAL; ADULT; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOLOGIC FACTORS; KILLER CELLS, NATURAL; LIVE BIRTH; LYMPHOCYTE COUNT; NATURAL KILLER T-CELLS; PREGNANCY; RETROSPECTIVE STUDIES; SPAIN;

EID: 84861934279     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2012.01135.x     Document Type: Article

References (37)

1. Branch DW, Gibson M, Silver RM : Recurrent miscarriage. N Engl J Med 2010; 363:1740-1747.
2. Rai R, Regan L : Recurrent miscarriage. Lancet 2006; 368:601-611.
3. Kwak-Kim J, Park JC, Ahn HK, Kim JW, Gilman-Sachs A : Immunological models of pregnancy loss. Am J Reprod Immunol 2010; 63:611-623.
4. Stephenson MD, William H, Kutteh WH, Purkiss S, Librach, Schultz P, Houlihan E, Liao C : Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebo-controlled trial. Hum Reprod 2010; 25:2203-2209.
5. Stricker RB, Steinleitner A, Winger EE : Intravenous immunoglobulin (IVIG) therapy for immunologic abortion. Clin Appl Immunol Rev 2002; 2:187-199.
6. Kwak-Kim J, Yang MK, Gilman-Sachs A : Recurrent pregnancy loss: a disease of inflammation and coagulation. J Obstet Gynaecol Res 2009; 35:6109-6622.
7. Perricone C, De Carolis C, Giacomelli R, Zaccari G, Cipriani P, Bizzi E, Perricone R : High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesis. Rheumatology 2007; 46:1574-1578.
8. Clark DA, Coulam CB, Stricker RB : Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF) J Assist Reprod Genet 2006; 23:1-13.
9. Lachapelle MH, Miron P, Hemmings R, Roy DC : Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol 1996; 56:4027-4034.
10. Coulam CB, Goodman C : Increased pregnancy rates after IVF/ET with intravenous immunoglobulin treatment in women with elevated circulating C56 + cells. Early Pregnancy 2000; 4:90-99.
11. Heilmann L, Schorsch M, Hahn T : CD3-CD56+CD16+ Natural Killer cells and improvement of pregnancy outcome in IVF/ICSI failure after additional IVIG-treatment. Am J Reprod Immunol 2010; 63:263-265.
12. van den Heuvel MJ, Peralta CG, Hatta K, Han VK, Clark DA : Decline in number of elevated blood CD3+CD56+ NKT cells in response to intravenous immunoglobulin treatment correlates with successful pregnancy. Am J Reprod Immunol 2007; 58:447-459.
13. Kopcow HD, Rosetti F, Leung Y, Allan DSJ, Kutok JL, Strominger JL : T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1. Proc Natl Acad Sci 2008; 25:105.
14. Boyson JE, Aktan I, Barkhuff DA, Chant A : NKT cells at the maternal-fetal interface. Immunol Invest 2008; 37:565-582.
15. Godfrey DI, MacDonald HR, Kronenberg N, Smyth MJ, Van KaerL : NKT cells: what's in a name? Nat Rev Immunol 2004; 4:231-237.
16. Uemura Y, Suzuki M, Liu TY, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S : Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy. Int Immunol 2008; 20:405-412.
17. Oliver-Miñarro D, Gil J, Aguaron A, Rodríguez-Mahou M, Fernandez-Cruz E, Sánchez-Ramón S : NK cell expansion in obstetrical antiphospholipid syndrome: Guilty by association? Eur J Obstet Gynecol Reprod Biol 2009; 145:227.
18. Kwak-Kim J, Chung-Bang HS, Ntrivalas EI, Mangubat CP, Beaman KD, Beer AE, Gilman-Sachs A : Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failure after IVF. Human Reprod 2003; 18:767-773.
19. H17 cells by intravenous immunoglobulin. J Allergy Clin Immunol 2011; 127:823-830.
20. De Groot AS, Moise L, McMurry JA, Wambre E, Van Overtvelt L, Moingeon P, Scott DS, Martin W : Activation of natural regulatory T cells by IgG Fc-derived peptide 'Tregitopes'. Blood 2008; 112:3303-3311.
21. Jacobi C, Claus M, Wildemann B, Wingert S, Korporal M, Römisch J, Meuer S, Watzl C, Giese T : Exposure of NK cells to intravenous immunoglobulin induces IFNγ release and degranulation but inhibits their cytotoxic activity. Clin Immunol 2009; 133:393-401.
22. Ruiz JE, Kwak JYH, Baum L, Gilman-Sachs A, Beaman KD, Kim YB, Beer AE : Effect of intravenous immunoglobulin G on natural killer cell cytotoxicity in vitro in women with recurrent spontaneous abortion. J Reprod Immunol 1996; 31:125-141.
23. Ata B, Tan SL, Shehata F, Holzer H, Buckett W : A systematic review of intravenous immunoglobulin for treatment of unexplained recurrent miscarriage. Fertil Steril 2011; 95:1080-1085.
24. Jablonowska B, Selbing A, Palfi M, Ernerudh J, Kjellberg S, Lindton B : Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: a double-blind placebo-controlled study. Hum Reprod 1999; 14:838-841.
25. Perino A, Vassiliadis A, Vucetich A, Colacurci N, Menato G, Cignitti M, Semprini AE : Short-term therapy for recurrent abortion using intravenous immunoglobulins: results of a double-blind placebo-controlled Italian study. Hum Reprod 1997; 12:2388-2392.
26. Stephenson MD, Dreher K, Houlihan E, Wu V : Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: a prospective, randomized, double-blinded, placebo-controlled trial. Am J Reprod Immunol 1998; 39:82-88.
27. Kwak JYH, Kwak FMY, Ainbinder SW, Ruiz AM, Beer AE : Elevated peripheral blood natural killer cells are effectively suppressed by immunoglobulin G infusions in women with recurrent spontaneous abortion. Am J Reprod Immunol 1996; 35:363-369.
28. Perricone R, Di Muzio G, Perricone C, Giacomelli R, De Nardo D, Fontana L, De Carolis C : High levels of peripheral blood NK cells in women suffering from recurrent spontaneous abortion are reverted from high-dose intravenous immunoglobulins. Am J Reprod Immunol 2006; 55:232-239.
29. Tha-In T, Bayry J, Metselaar HJ, Kaveri SV, Kwekkeboom J : Modulation of the cellular immune system by intravenous immunoglobulin. Trend Immunol 2008; 29:608-615.
30. Arruvito L, Sotelo AI, Billordo A, Fainboim L : A physiological role for inducible FOXP3 + TREG cells. Lessons from women with reproductive failure. Clin Immunol 2010; 136:432-441.
31. Liu Y-S, Wu L, Tong X-H, Wu L-M, He G-P, Zhou G-X, Luo L-H, Luan H-B : Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion. Am J Reprod Immunol 2011; 65:503-511.
32. Scher J, Salazar zC : Clinical experience with IVIg Rx in patients with prior failed ivf pregnancies: report of 30 consecutive patients. Am J Reprod Immunol 2000; 44:121-124.
33. Williams PJ, Searle RF, Robson SC, Innes BA, Bulmer JN : Decidual leucocyte populations in early to late gestation normal human pregnancy. J Reprod Immunol 2009; 82:24-31.
34. ®) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am J Reprod Immunol 2009; 61:113-120.
35. Goodman CS, Coulam CB, Jeyendran RS, Acosta VA, Roussev R : Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? Am J Reprod Immunol 2006; 56:230-236.
36. Coulam CB, Wallis D, Weinstein J, DasGupta DS, Jeyendran RS : Comparison of thrombophilic gene mutations among patients experiencing recurrent miscarriage and deep vein thrombosis. Am J Reprod Immunol 2008; 60:426-431.
37. Carp HJA, Toder V, Gazit E, Ahiron R, Torchinski A, Mashiach S, Shoenfeld Y : Further experience with intravenous immunoglobulin in women with recurrent miscarriage and a poor prognosis. Am J Reprod Immunol 2001; 46:268-273.