Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells

Fertility and Sterility

Volumn 93, Issue 8, 2010, Pages 2581-2587

  Fluhr, Herbert ^a   Spratte, Julia ^a   Ehrhardt, Jens ^a   Steinmüller, Frauke ^a   Licht, Peter ^b   Zygmunt, Marek ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b Fertility Center Nuremberg   (Germany)

Author keywords

decidualization; endometrium; Heparin; IGF I; IGFBP 1; implantation; low molecular weight heparin; PRL

Indexed keywords

CYCLIC AMP; ESTRADIOL; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PROGESTERONE; PROLACTIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

ARTICLE; CELL VIABILITY; DECIDUALIZATION; ENDOMETRIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYSTERECTOMY; IN VITRO STUDY; LUMINESCENCE; PREMENOPAUSE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL;

CYCLIC AMP; DECIDUA; ENDOMETRIUM; FEMALE; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR I; PROLACTIN; STROMAL CELLS;

EID: 77952108513     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.10.025     Document Type: Article

References (37)

1. Greer I., and Hunt B.J. Low molecular weight heparin in pregnancy: current issues. Br J Haematol 128 (2005) 593-601
2. Shriver Z., Sundaram M., Venkataraman G., Fareed J., Linhardt R., Biemann K., et al. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin. Proc Natl Acad Sci USA 97 (2000) 10365-10370
3. Kutteh W.H. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 174 (1996) 1584-1589
4. Rai R., Cohen H., Dave M., and Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 314 (1997) 253-257
5. Nelson S.M., and Greer I.A. The potential role of heparin in assisted conception. Hum Reprod Update 14 (2008) 623-645
6. Sebire N.J., Backos M., El Gaddal S., Goldin R.D., and Regan L. Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent miscarriage patients. Obstet Gynecol 101 (2003) 258-263
7. Rey E., Kahn S.R., David M., and Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361 (2003) 901-908
8. Badawy A.M., Khiary M., Sherif L.S., Hassan M., Ragab A., and Abdelall I. Low-molecular weight heparin in patients with recurrent early miscarriages of unknown aetiology. J Obstet Gynaecol 28 (2008) 280-284
9. Young E. The antiinflammatory effects of heparin and related compounds. Thromb Res 122 (2008) 743-752
10. Andersen A.N., Goossens V., Ferraretti A.P., Bhattacharya S., Felberbaum R., de Mouzon J., et al. Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Hum Reprod 23 (2008) 756-771
11. Hills F.A., Abrahams V.M., Gonzalez-Timon B., Francis J., Cloke B., Hinkson L., et al. Heparin prevents programmed cell death in human trophoblast. Mol Hum Reprod 12 (2006) 237-243
12. Ganapathy R., Whitley G.S., Cartwright J.E., Dash P.R., and Thilaganathan B. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod 22 (2007) 2523-2527
13. Urman B., Ata B., Yakin K., Alatas C., Aksoy S., Mercan R., et al. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial. Hum Reprod 24 (2009) 1640-1647
14. Strowitzki T., Germeyer A., Popovici R., and von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update 12 (2006) 617-630
15. Dunn C.L., Kelly R.W., and Critchley H.O. Decidualization of the human endometrial stromal cell: an enigmatic transformation. Reprod Biomed Online 7 (2003) 151-161
16. Wilcox A.J., Baird D.D., and Weinberg C.R. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 340 (1999) 1796-1799
17. Giudice L.C., and Irwin J.C. Roles of the insulinlike growth factor family in nonpregnant human endometrium and at the decidual: trophoblast interface. Semin Reprod Endocrinol 17 (1999) 13-21
18. Irwin J.C., and Giudice L.C. Insulin-like growth factor binding protein-1 binds to placental cytotrophoblast alpha5beta1 integrin and inhibits cytotrophoblast invasion into decidualized endometrial stromal cultures. Growth Horm IGF Res 8 (1998) 21-31
19. Wu W.X., Brooks J., Glasier A.F., and McNeilly A.S. The relationship between decidualization and prolactin mRNA and production at different stages of human pregnancy. J Mol Endocrinol 14 (1995) 255-261
20. Garzia E., Borgato S., Cozzi V., Doi P., Bulfamante G., Persani L., et al. Lack of expression of endometrial prolactin in early implantation failure: a pilot study. Hum Reprod 19 (2004) 1911-1916
21. Jabbour H.N., and Critchley H.O. Potential roles of decidual prolactin in early pregnancy. Reproduction 121 (2001) 197-205
22. Fluhr H., Carli S., Deperschmidt M., Wallwiener D., Zygmunt M., and Licht P. Differential effects of human chorionic gonadotropin and decidualization on insulin-like growth factors-I and -II in human endometrial stromal cells. Fertil Steril 90 (2007) 1384-1389
23. Fluhr H., Krenzer S., Deperschmidt M., Zwirner M., Wallwiener D., and Licht P. Human chorionic gonadotropin inhibits insulin-like growth factor-binding protein-1 and prolactin in decidualized human endometrial stromal cells. Fertil Steril 86 (2006) 236-238
24. von Wolff M., Stieger S., Lumpp K., Bucking J., Strowitzki T., and Thaler C.J. Endometrial interleukin-6 in vitro is not regulated directly by female steroid hormones, but by pro-inflammatory cytokines and hypoxia. Mol Hum Reprod 8 (2002) 1096-1102
25. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
26. Dimitriadis E., Robb L., and Salamonsen L.A. Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol Hum Reprod 8 (2002) 636-643
27. Rajgopal R., Butcher M., Weitz J.I., and Shaughnessy S.G. Heparin synergistically enhances interleukin-11 signaling through up-regulation of the MAPK pathway. J Biol Chem 281 (2006) 20780-20787
28. Walton K.J., Duncan J.M., Deschamps P., and Shaughnessy S.G. Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation. Blood 100 (2002) 2530-2536
29. Khurana S., Kuns R., and Ben Jonathan N. Heparin-binding property of human prolactin: a novel aspect of prolactin biology. Endocrinology 140 (1999) 1026-1029
30. Eyal O., Jomain J.B., Kessler C., Goffin V., and Handwerger S. Autocrine prolactin inhibits human uterine decidualization: a novel role for prolactin. Biol Reprod 76 (2007) 777-783
31. Chobotova K., Karpovich N., Carver J., Manek S., Gullick W.J., Barlow D.H., et al. Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. J Clin Endocrinol Metab 90 (2005) 913-919
32. Irwin J.C., Kirk D., King R.J., Quigley M.M., and Gwatkin R.B. Hormonal regulation of human endometrial stromal cells in culture: an in vitro model for decidualization. Fertil Steril 52 (1989) 761-768
33. Gellersen B., and Brosens J. Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair. J Endocrinol 178 (2003) 357-372
34. Licht P., Russu V., Lehmeyer S., Moll J., Siebzehnrubl E., and Wildt L. Intrauterine microdialysis reveals cycle-dependent regulation of endometrial insulin-like growth factor binding protein-1 secretion by human chorionic gonadotropin. Fertil Steril 78 (2002) 252-258
35. Gleeson L.M., Chakraborty C., McKinnon T., and Lala P.K. Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein kinase pathway. J Clin Endocrinol Metab 86 (2001) 2484-2493
36. Irving J.A., and Lala P.K. Functional role of cell surface integrins on human trophoblast cell migration: regulation by TGF-beta, IGF-II, and IGFBP-1. Exp Cell Res 217 (1995) 419-427
37. Gubbay O., Critchley H.O., Bowen J.M., King A., and Jabbour H.N. Prolactin induces ERK phosphorylation in epithelial and CD56(+) natural killer cells of the human endometrium. J Clin Endocrinol Metab 87 (2002) 2329-2335